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人血淸의 C. Albicam에 對한 抗菌性物質에 對해서
鄭在奎,徐桂益,張炳榮,鄭純鎔 최신의학사 1969 最新醫學 Vol.12 No.2
Pooled healthy human sera exhibited a marked growth inhibitary action in vitro against strains of C. albicans and this action was stronger than that of pooled rabbit sera. Growth inhibitory substance to C. albicans which is contained in serum has not been absorbed with zymosan or digested by trypsin, but destroyed by ox bile or sodium desoxychoiate, this illustrats that the antibacterial substance contained in serum is not exactly the same one as that of anticandidial substance.
Chioromycetin이 typhoid 抗體形成에 미치는 影響
鄭在奎 慶北大學校 醫科大學 1958 慶北醫大誌 Vol.1 No.1
The use of various kinds of antibiotics made the symptoms and prognosis of diseases different from the time when they were not in use. In case of the enteric infections such as typhoid or paratyphoid, the clinical symptoms usually subside drastically when Chloromycetin is used. In such cases widal reactions are not necessarily of clinical significance and it generally difficult to make a definite diagnosis when antibiotics were given in the early stage of diseases. Bacteriological and immunological studies were made in October ?? ?? typhoid fever which occurred in a limited epidemic form among the students of Nursing School of Kyungpook University. Routine culture study, biochemical and immunological reactions were performed to identify the isolated micro-organism of the disease as well as to detect the development of widal antibody in the patients who took various doses of Chloromycetin indiscriminately ranging total amount of 1.5 to 25 gr. in the entire course of the disease. In order to observe the antibody formation in the experimental animals after the use of Chloromycetin 6 groups of rabbits were inoculated with bacterial suspension and this was followed by oral adminstration of chloromycetion 100㎎ /㎏. body wt. daily. The duration of Chloromycetin administration varied in each group. Among the entire 14 patients the micro-organism was isolated in 7 cases, and all strains were indentified by means of biochemical and immunological procedures. These strains were slightly resistant to various antibiotics as compared to the original strains of Typhoid A-58. Widal antibodies of the patients were generally lower than the previously accepted level of antibody and correlate with the experimental results. However, antibody titer tested by killed bacterial suspension prepared with Chloromycetin has not been different substantially from that which was prepared with heat.
Candida ablicans에 對한 miconazole nitrate, nystatin 및 rifampin의 單獨 및 倂合抗菌作用에 關하여
鄭在奎 대한화학요법학회 1983 대한화학요법학회지 Vol.1 No.1
With 110 clinical isolates of Candida albicans, growth inhibitory actions of miconazole nitrate and nystatin alone or in combination with rifampin were evaluated, On Sabouraud glucose plate, miconazole nitrace combined with ridampin showed weak additive reaction against tyo straifls, indifferent t o four, and antagonistic to four, and when miconazob nitrate combined with nystatin, two strains showed weak additive, one was indifferent and seven showed antagonistic reactions, but all strains exhibited weak additive reaction when nystatin combined with rifampin. In Sabouraud broth, also weak reactions of both additive or antagonistic were observed according to the strains and to the combination of drugs. However. none of the drug combination exhibited clear results to be termed as synergistic or antagonisticc reaction.
정재규,임윤정,Jae Gu Jung,Yun Jeong Lim 대한소화기암연구학회 2013 Journal of digestive cancer reports Vol.1 No.1
Peritoneal carcinomatosis (PC) is defined as the dissemination of cancer cells in the peritoneal cavity resulting in deposition of malignant cells onto parietal or visceral peritoneal surfaces, and is associated with malignant ascites. In general, PC has been treated similarly to metastatic cancers of the primary tumor, but associated with unfavorable outcomes as compared to other sites of metastatic disease from the same primary tumor origin. It has been known to have the median survival of only 3-6 months with supportive care alone. PC is an intractable problem to physicians because of its poor prognosis and limited treatment options. Recent studies have reported that a combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improved survival in PC of colorectal cancer. This paper gives overviews of the characteristics, symptoms, prognosis, and diagnosis of PC and current treatment options on PC of stomach, colorectal, and unknown primary origin.