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( Yoo Li Lim ),( Eunhee Choi ),( Yoon Ok Jang ),( Youn Zoo Cho ),( Yong Seok Kang ),( Soon Koo Baik ),( Sang Ok Kwon ),( Moon Young Kim ) 대한소화기기능성질환·운동학회 2016 Gut and Liver Vol.10 No.1
Background/Aims: Levels of serum apelin (s-apelin), an endogenous ligand for angiotensin-like receptor 1, have been shown to be related to hepatic fibrosis and hemodynamic abnormalities in preclinical studies. We investigated the clinical implications of s-apelin as a noninvasive prognostic biomarker for chronic liver disease (CLD). Methods: From January 2009 to December 2012, 215 CLD patients were enrolled and underwent clinical data collection, hepatic venous pressure gradient (HVPG) measurement, and liver biopsy. s-apelin was detected with a human total apelin enzyme-linked immunosorbent assay kit. All patients were prospectively observed during the median follow-up period of 23.0±12.9 months for decompensation and mortality. Results: A total of 42 patients (19.5%) died during the follow-up period. s-apelin was significantly correlated with measurements of liver stiffness (R2=0.263, p<0.001) and collagen proportional area (R2=0.213, p<0.001) measured from liver biopsy tissue and HVPG (R2=0.356, p<0.001). In a multivariate analysis using a Cox regression hazard model, s-apelin was a weakly significant predictor of decompensation (hazard ratio [HR], 1.002; p<0.001) and mortality (HR, 1.003; p<0.001). Conclusions: s-apelin showed a significant relationship with CLD severity. However, its significance as a noninvasive biomarker for disease severity and prognosis was weak. (Gut Liver 2016;10:109-116)
( A. S. Berdinsky ),( D. Fink ),( Hui Gon Chun ),( Yong Zoo Yoo ),( Ji Beom Yoo ),( A. V. Petrov ),( P. S. Alegaonkar ) 한국센서학회 2004 센서학회지 Vol.13 No.5
N/A It is known that the conductivity of fullerite depends on the applied pressure. In this paper we compare the variation of conductivity of three different fullerite structure with pressure. We examined C_(60) powder, filled into thin glass capillaries and also studied fullerite nanotubules produced within etched swift heavy ion tracks in polymer foils. These investigations are compared with the results of planar Si-C_(60)-Au structures.
( A. S. Berdinsky ),( Yu. V. Shevtsov ),( Hui Gon Chun ),( Yong Zoo Yoo ),( D. Fink ),( B. M. Ayupov ) 한국센서학회 2004 센서학회지 Vol.13 No.5
N/A We report on the technology of formation of sandwich structures based on fullerite films and on experimental results in research of optical and conductivity properties of these sandwich samples. Single crystals of sapphire (100) or silicon were used as substrates. The sandwich specimens were based on the structure M/C_(60)/M (M=Cr, Pd, Ag, Al, Cu). The thickness of the fullerite films was about 0.2~1.0 μm. The area of the C50 film under the top contact was about I cm². The specimens have been investigated by infrared spectroscopy, spectra-photometry. ellipsometry and X-ray diffraction analysis. Measurements of the current/voltage characteristics and research on the temperature dependence of conductivity were performed as well. It was shown that metals such as Cr, Pd. Ag. Al, and Cu penetrate easily into the fullerite films. It appears that these specimens have a large conductivity. For silver/C_(60) and other sandwich structures the conductivities show a semiconductor-like behaviour.
( Won Ki Hong ),( Moon Young Kim ),( Soon Koo Baik ),( Seung Yong Shin ),( Jung Min Kim ),( Yong Seok Kang ),( Yoo Li Lim ),( Young Ju Kim ),( Youn Zoo Cho ),( Hye Won Hwang ),( Jin Hyung Lee ),( Myeo 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.4
Background/Aims: Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. Methods: LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. Results: A strong positive correlation between LSM and HVPG was observed in the overall population (r2=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively. Conclusions: LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis.