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Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
Yang, Bo,Wang, Yi-Qi,Cheng, Ru-Bin,Chen, Jia-Li,Chen, Jin,Jia, Li-Tao,Zhang, Ru-Song Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Our previous study demonstrated cytotoxicity of a crude extract from Patrinia heterophylla Bunge (PHEB). In the present study, we aimed to investigate the effects of isovaltrate acetoxyhydrin (IA) isolated from PHEB on the gastric cancer cell SGC-7901, in order to explore a potential treatment for gastric cancer. Methods: MTT assays were employed to determine the effects of IA on cell vitality and proliferation, with monitoring of cell morphology changes and examination of apoptosis with Annexin V-PI staining. Flow cytometry was used to assess cell cycle progression and mitochondrial membrane potential. The activity of caspase 3, 9 was evaluated by spectrophotometry, and the protein levels of Bax, Bcl2 and Cyclin B1 were analyzed with Western blotting of total proteins extracted from cultured cells. Results: The results demonstrated direct toxicity of IA towards SGC-7901 cells. Evidence of apoptosis included blebbing and chromatin condensation. Annexin V-PI assays revealed early apoptosis, involving rapid depolarization of mitochondrial membranes and activity of caspase 3, 9 signaling pathways. Western blotting showed that Bcl2 and Bax proteins was down- and up-regulated, respectively, and cyclin B1 was up-regulated. Cell cycle analysis further indicated that IA could induce G2/M phase arrest in SGC-7901 cells. Conclusions: In conclusion, we believe that IA induces apoptosis of SGC-7901 cells, therefore providing a potential therapeutic agent for treatment of gastric cancer.
Jia Yang,Jiajia Hao,Chen Tang,Yaxin Guo,Mingxin Guo,Zhipeng Li,Shuzheng Liu,Hui Yu,Gang Qin,Qiang Chen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Although many hydrogels have been applied to wearable sensors, it is still challenging to simultaneouslyrealize hydrogels with optical transparency, superior mechanical properties, excellent sensing performance,and anti-freezing by using inexpensive raw materials and an easy preparation process. Herein,using ethylene glycol/H2O (EG/ H2O) as a solvent, poly(vinyl alcohol)/EG organohydrogel (PVA/EGOHG) was prepared by a simple heating and frozen-thawing method. Owing to the multifunctionalityof EG (i.e., physical cross-linker, anti-freezer and co-solvent), PVA/EG OHG demonstrated excellent integratedproperties, including high strength, high toughness, and anti-freezing performances. Besides, PVA/EG OHG also showed low friction, self-cleaning, and frost resistance properties. After the introduction ofLiCl, ionically conductive PVA/EG @LiCl organohydrogel was served as a self-cleaning strain sensor, whichcould be long-term stable to detect the motions of human under room and low temperatures. The studyprovides to further understanding of the organohydrogel, which will help us design next-generationhigh-performance organohydrogels.
Jia, Wei-Juan,Jia, Hai-Xia,Feng, Hui-Yi,Yang, Ya-Ping,Chen, Kai,Su, Feng-Xi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Purpose: The purpose of this study was to investigate the recurrence pattern and characteristics of patients based on the 2013 St. Gallen surrogate molecular subtypes after breast-conserving surgery (BCS) in Chinese women. Methods: This retrospective analysis included 709 consecutive breast cancer patients undergoing BCS from 1999-2010 at our institution. Five different surrogate subtypes were created using combined expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2. Locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS) rates were calculated. Results: The 5-year LRRFS, DMFS, and DFS rates were 90.5%, 88.2%, and 81.5%, respectively. Multivariate analysis revealed that young age, node-positive disease, and HER2 enrichment were independent prognostic factors in LRRFS patients. There was also an independent prognostic role of lymph node-positive disease in DMFS and DFS patients. Patients with luminal A tumors had the most favorable prognosis, with LRRFS, DMFS, and DFS rates of 93.2%, 91.5%, and 87.4% at 5 years, respectively. Conversely, HER-2-enriched tumors exhibited the highest rate of locoregional recurrence (20.6%). Conclusion: Surrogate subtypes present with significant differences in RFS, DMFS, and LRRFS. Luminal A tumors have the best prognosis, whereas HER2-enriched tumors have the poorest.
Yang Hui-Hui,Jiang Hui-Ling,Tao Jia-Hao,Zhang Chen-Yu,Xiong Jian-Bing,Yang Jin-Tong,Liu Yu-Biao,Zhong Wen-Jing,Guan Xin-Xin,Duan Jia-Xi,Zhang Yan-Feng,Liu Shao-Kun,Jiang Jian-Xin,Zhou Yong,Guan Cha-Xi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citratemt) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3α and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition of Idh3α and Slc25a1 induced citratemt accumulation and necroptosis in vitro. Mice with AEC-specific Idh3α and Slc25a1 deficiency exhibited exacerbated lung injury and AEC necroptosis. Interestingly, the overexpression of Idh3α and Slc25a1 decreased citratemt levels and rescued AECs from necroptosis. Mechanistically, citratemt accumulation induced mitochondrial fission and excessive mitophagy in AECs. Furthermore, citratemt directly interacted with FUN14 domain-containing protein 1 (FUNDC1) and promoted the interaction of FUNDC1 with dynamin-related protein 1 (DRP1), leading to excessive mitophagy-mediated necroptosis and thereby initiating and promoting ALI. Importantly, necroptosis induced by citratemt accumulation was inhibited in FUNDC1-knockout AECs. We show that citratemt accumulation is a novel target for protection against ALI involving necroptosis.
Jia-An Zhang,Nian-Fa Yang,Li-Wen Yang,Shi Wu,Ye-Hui Chen,Jin Zhang 한국고분자학회 2013 Macromolecular Research Vol.21 No.6
Three new chiral bisacylphosphine oxides, (-)-bis(menthylformyl)phenylphosphine oxide (1a), (+)-bis(2,4,6-trimethylbenzoyl)menthylphosphine oxide (2a), and (-)-bis(menthylformyl)menthylphosphine oxide (3a),were synthesized using menthol as a chiral source. The synthesized new chiral bisacylphosphine oxides were used as photoinitiators for the polymerization of 1-phenyldibenzosuberyl methacrylate (PDBSMA). The polymerization initiated by chiral bisacylphosphine oxides under UV light irradiation is helix-sense-selective. Among the three prepared chiral bisacylphosphine oxides, the helix-sense-selectivity of bis(menthylformyl)menthylphosphine oxide is highest. The highest specific rotation of poly(1-phenyldibenzosuberyl methacrylate) at 365 nm is +416. The feed molar ratio of monomer to chiral bisacylphosphine oxide and the polymerization temperature have an influence on the helix-sense-selectivity. The lower the feed molar ratio of monomer to chiral bisacylphosphine oxide, the better the helix-sense-selectivity is. The increase of polymerization temperature is propitious to increase the helix-senseselectivity of the photopolymerization.
Jia Yang,Qiong Kang,Bin Zhang,Xiyu Tian,Shuzheng Liu,Gang Qin,Qiang Chen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
Ionic conductive hydrogel-based sensors have been capturing growing attention in various areas, but stillcannot satisfy the operating requirements of next generation wearable electronics. Herein, inspired bybiosystems, we demonstrate ionic conductive supramolecular hydrogels with simple one-step methodbased on salting-out effect and multiple hydrogen bond interactions. The supramolecular hydrogels exhibithigh toughness and strength, quick self-recovery, high sensitive sensing performance as well as goodself-healing, fatigue and frost resistances in mechanical and sensing properties, and can monitor largeand subtle movements and physiological activities of the human body sensitively, quickly and stably. Thus, it provides a convenient and promising way to obtain stretchable sensors of excellent comprehensiveproperties, which have tremendous application potential as wearable electronic devices in harshenvironments.
Jia-Chen Yang,Jia-Yu Chen,Yin Ding,Yong-Jie Yin,Zhi-Ping Huang,Xiu-Hua Wu,Zu-Cheng Huang,Yi-Kai Li,Qing-An Zhu 대한척추신경외과학회 2024 Neurospine Vol.21 No.1
Objective: The effect on fat infiltration (FI) of paraspinal muscles in degenerative lumbar spinal diseases has been demonstrated except for spinopelvic parameters. The present study is to identify the effect of spinopelvic parameters on FI of paraspinal muscle (PSM) and psoas major muscle (PMM) in patients with degenerative lumbar spondylolisthesis. Methods: A single-center, retrospective cross-sectional study of 160 patients with degenerative lumbar spondylolisthesis (DLS) and lumbar stenosis (LSS) who had lateral full-spine x-ray and lumbar spine magnetic resonance imaging was conducted. PSM and PMM FIs were defined as the ratio of fat to its muscle cross-sectional area. The FIs were compared among patients with different pelvic tilt (PT) and pelvic incidence (PI), respectively. Results: The PSM FI correlated significantly with pelvic parameters in DLS patients, but not in LSS patients. The PSM FI in pelvic retroversion (PT > 25°) was 0.54 ± 0.13, which was significantly higher in DLS patients than in normal pelvis (0.41 ± 0.14) and pelvic anteversion (PT < 5°) (0.34 ± 0.12). The PSM FI of DLS patients with large PI ( > 60°) was 0.50 ± 0.13, which was higher than those with small ( < 45°) and normal PI (0.37 ± 0.11 and 0.36 ± 0.13). However, the PSM FI of LSS patients didn’t change significantly with PT or PI. Moreover, the PMM FI was about 0.10–0.15, which was significantly lower than the PSM FI, and changed with PT and PI in a similar way of PSM FI with much less in magnitude. Conclusion: FI of the PSMs increased with greater pelvic retroversion or larger pelvic incidence in DLS patients, but not in LSS patients.