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RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure
Gao, Chen,Ren, Shuxun,Lee, Jae-Hyung,Qiu, Jinsong,Chapski, Douglas J.,Rau, Christoph D.,Zhou, Yu,Abdellatif, Maha,Nakano, Astushi,Vondriska, Thomas M. American Society for Clinical Investigation 2016 The Journal of clinical investigation Vol.126 No.1
Zhang, Chen,Milunsky, Jeff M,Newton, Stephanie,Ko, Jaewon,Zhao, Geping,Maher, Tom A,Tager-Flusberg, Helen,Bolliger, Marc F,Carter, Alice S,Boucard, Antony A,Powell, Craig M,Sü,dhof, Thomas C The Society 2009 The Journal of neuroscience Vol.29 No.35
<P>Neuroligins (NLs) are postsynaptic cell-adhesion molecules essential for normal synapse function. Mutations in neuroligin-4 (NL4) (gene symbol: NLGN4) have been reported in some patients with autism spectrum disorder (ASD) and other neurodevelopmental impairments. However, the low frequency of NL4 mutations and the limited information about the affected patients and the functional consequences of their mutations cast doubt on the causal role of NL4 mutations in these disorders. Here, we describe two brothers with classical ASD who carry a single amino-acid substitution in NL4 (R87W). This substitution was absent from the brothers' asymptomatic parents, suggesting that it arose in the maternal germ line. R87 is conserved in all NL isoforms, and the R87W substitution is not observed in control individuals. At the protein level, the R87W substitution impaired glycosylation processing of NL4 expressed in HEK293 and COS cells, destabilized NL4, caused NL4 retention in the endoplasmic reticulum in non-neuronal cells and neurons, and blocked NL4 transport to the cell surface. As a result, the R87W substitution inactivated the synapse-formation activity of NL4 and abolished the functional effect of NL4 on synapse strength. Viewed together, these observations suggest that a point mutation in NL4 can cause ASD by a loss-of-function mechanism.</P>
Classification of Traffic Flows into QoS Classes by Unsupervised Learning and KNN Clustering
( Yi Zeng ),( Thomas M. Chen ) 한국인터넷정보학회 2009 KSII Transactions on Internet and Information Syst Vol.3 No.2
Traffic classification seeks to assign packet flows to an appropriate quality of service (QoS) class based on flow statistics without the need to examine packet payloads. Classification proceeds in two steps. Classification rules are first built by analyzing traffic traces, and then the classification rules are evaluated using test data. In this paper, we use self-organizing map and K-means clustering as unsupervised machine learning methods to identify the inherent classes in traffic traces. Three clusters were discovered, corresponding to transactional, bulk data transfer, and interactive applications. The K-nearest neighbor classifier was found to be highly accurate for the traffic data and significantly better compared to a minimum mean distance classifier.
Branched TiO<sub>2</sub> Nanorods for Photoelectrochemical Hydrogen Production
Cho, In Sun,Chen, Zhebo,Forman, Arnold J.,Kim, Dong Rip,Rao, Pratap M.,Jaramillo, Thomas F.,Zheng, Xiaolin American Chemical Society 2011 Nano letters Vol.11 No.11
<P>We report a hierarchically branched TiO<SUB>2</SUB> nanorod structure that serves as a model architecture for efficient photoelectrochemical devices as it simultaneously offers a large contact area with the electrolyte, excellent light-trapping characteristics, and a highly conductive pathway for charge carrier collection. Under Xenon lamp illumination (UV spectrum matched to AM 1.5G, 88 mW/cm<SUP>2</SUP> total power density), the branched TiO<SUB>2</SUB> nanorod array produces a photocurrent density of 0.83 mA/cm<SUP>2</SUP> at 0.8 V versus reversible hydrogen electrode (RHE). The incident photon-to-current conversion efficiency reaches 67% at 380 nm with an applied bias of 0.6 V versus RHE, nearly two times higher than the bare nanorods without branches. The branches improve efficiency by means of (i) improved charge separation and transport within the branches due to their small diameters, and (ii) a 4-fold increase in surface area which facilitates the hole transfer at the TiO<SUB>2</SUB>/electrolyte interface.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-11/nl2029392/production/images/medium/nl-2011-029392_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl2029392'>ACS Electronic Supporting Info</A></P>
Rates of cavity filling by liquids
Seo, Dongjin,Schrader, Alex M.,Chen, Szu-Ying,Kaufman, Yair,Cristiani, Thomas R.,Page, Steven H.,Koenig, Peter H.,Gizaw, Yonas,Lee, Dong Woog,Israelachvili, Jacob N. National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.32
<P>Understanding the fundamental wetting behavior of liquids on surfaces with pores or cavities provides insights into the wetting phenomena associated with rough or patterned surfaces, such as skin and fabrics, as well as the development of everyday products such as ointments and paints, and industrial applications such as enhanced oil recovery and pitting during chemical mechanical polishing. We have studied, both experimentally and theoretically, the dynamics of the transitions from the unfilled/partially filled (Cassie-Baxter) wetting state to the fully filled (Wenzel) wetting state on intrinsically hydrophilic surfaces (intrinsic water contact angle <90 degrees, where the Wenzel state is always the thermodynamically favorable state, while a temporary metastable Cassie-Baxter state can also exist) to determine the variables that control the rates of such transitions. We prepared silicon wafers with cylindrical cavities of different geometries and immersed them in bulk water. With bright-field and confocal fluorescence microscopy, we observed the details of, and the rates associated with, water penetration into the cavities from the bulk. We find that unconnected, reentrant cavities (i.e., cavities that open up below the surface) have the slowest cavity-filling rates, while connected or non-reentrant cavities undergo very rapid transitions. Using these unconnected, reentrant cavities, we identified the variables that affect cavity-filling rates: (i) the intrinsic contact angle, (ii) the concentration of dissolved air in the bulk water phase (i.e., aeration), (iii) the liquid volatility that determines the rate of capillary condensation inside the cavities, and (iv) the presence of surfactants.</P>
Responses of Varroa-resistant honey bees (Apis mellifera L.) to Deformed wing virus
Kitiphong Khongphinitbunjong,Lilia I. de Guzman,Thomas E. Rinderer,Matthew R. Tarver,Amanda M. Frake,Yanping Chen,Panuwan Chantawannakul 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.4
The negative impact of Deformedwing virus (DWV) on European honey bees Apis mellifera is magnified by Varroa destructor parasitism. This study compared the responses of two Varroa-resistant honey bee stocks, pure Russian honey bees (RHB) and out-crossed Varroa Sensitive Hygienic bees, Pol-line (POL) to DWV infection to that of Varroa- susceptible stock, Italian honey bees (IHB). Two-day-old larvae were fed with DWV lysate in different concentrations: undiluted DWV lysate (D1), D1:100, and D1:1000. The unfed larvae served as negative control. Combs containing test larvae were exposed to a common environment during their development using host colonies. Our results showed that only POL displayed variation in DWV levels when fed different DWV concentrations. POL fed highest concentration of DWV inoculum had the highest increase in DWV level than those fed low concentrations and unfed POL. This high increase in DWV level probably contributed to the decrease in the survival and median longevity (LT50) of D1-fed POL. Weights of newly eclosed D1-fed POL were similar to those of the two controls and DWV-fed bees. However, within IHB, D1-fed bees showed significant reductions in weight, days of survival and LT50. Regardless of the concentrations of DWV inoculum, the DWV levels were similarly low within RHB; adult bees had similar weights. Overall, larvae fed D1 had the highest rate of wing deformation. POL and RHB had numerically lower proportions of bees with deformed wings. This study suggests that RHB showed some degree of resistant to DWV as shown by no reduction on weight and numerically lower proportion of wing deformity when compared with the other bee stocks.