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Chung, Eunkyung,Yoon, Tae Gyoon,Kim, Sumin,Kang, Moonkyu,Kim, Hyun Jeong,Son, Youngsook The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3
This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4-L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.
( Sumin Oh ),( Hyun Hoon Chung ),( Jae Weon Kim ),( Yong Sang Song ),( Noh Hyun Park ),( Yoo Kyung Lee ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Objective: Despite the good prognosis of borderline ovarian tumors (BOTs), a few BOT patients experience the relapse of disease. Among them, some reveal the cancerous disease, however, the risk of malignant transformation of BOT is usually thought to be unclear. We intended to find out the specific characteristics and prognosis of cancerous recurrence from BOTs. Methods: Between 1995 and 2012, 130 women were diagnosed with BOTs in our institution. Seven patients diagnosed and treated for cancerous recurrence of BOTs were included for analysis in this retrospective study. Clinicopathological characteristics and surgical procedure as well as follow-up data with overall survival were assessed. Statistical analyses included the χ2 test, t-test and Log-rank test with Cox regression. Result: One hundred and thirty patients with mean follow-up of 65.8 months (range, 1 to 241 months) were evaluated, of whom half were below 40 years-old at their first diagnosis of BOTs and 53.8% received conservative surgery. In our cohort, mucinous pathologic type was the most common one (66.9%). Among 11 patients who were diagnosed relapse of BOTs (8.5%), seven cancerous transformations were detected (5.4%) with median time of 9 months (range, 1 to 54 months). All cancerous relapses arose from premenopausal women of median age of 35 years old. Tumor size and tumor markers level (CA-125 and CA 19-9) did not show any predictive value for the malignant transformation of BOTs. Laparoscopic approach and conservative surgery were revealed that had no significant influence on relapse and overall survival (p=0.602, p=0.543). The median survival time of cancerous recurrent cases is 9 months (range, 3 to 31 months). Among them, four died of recurrent disease (ovarian cancer) and the other 3 has been reached complete remission. Conclusion: Minimal invasive conservative surgery for BOTs can be accepted under close follow-ups. However, survival rate of disease can be expected to be poor if malignant transformation of BOTs occurred.
( Eunkyung Chung ),( Tae Gyoon Yoon ),( Sumin Kim ),( Moonkyu Kang ),( Hyun Jeong Kim ),( Youngsook Son ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3
This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey`s test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4- L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.
Jeong Seula,Chung Yuheon,박소진,Lee Sumin,Choi Nayoung,Park Jong Kun 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1
Background Ultraviolet B (UVB), a major cause of skin photoaging, leads to DNA damage directly and indirectly in skin cells. DNA damage can contribute to aging by increasing apoptosis, cellular senescence and cell dysfunction. To prevent photoaging and rejuvenate photoaged skin, combinations of active compounds from natural products are used for medicine and cosmetic ingredients. Objective In this study, we investigated the synergistic effects of Rg2 and piceatannol (PIC) mixture (RP) on protecting skin against UVB-induced DNA damage in HaCaT cells. Results Cells treated with RP for 24 h post UVB exposure increased the cell viability in a concentration-dependent manner compared to non-treated control. In DPPH and DCF-DA assay, RP showed similar free radical scavenging activity to that of single-treatment PIC. RP more decreased the levels of CPD, DDR proteins including p53, p-p53 and p21 and apoptosisrelated proteins, such as Bax, Bim, and cleaved caspase-7 than that of single-treatment PIC or Rg2. Also, RP decreased more the mRNA level of MMP-1, -3 and -9 than that of single-treatment PIC or Rg2. Conclusion It is inferred that Rg2 promotes DNA repair by regulating genes related with DDR and PIC promotes DNA repair by effectively scavenging UVB-induced ROS through high antioxidant activity. Enhanced DNA repair by RP leads to protecting skin from UVB-induced skin photoaging.
류수민(Ryu, Sumin),이연선(Lee, Younsun),이소민(Lee, Somin),정계숙(Chung, Kai-Sook) 경성대학교 인문과학연구소 2014 인문학논총 Vol.34 No.-
본 연구는 교육정책변화 속에서 서로 다른 교육철학과 프로그램을 갖고 있는 유아교육기관이 현장에서 부모교육을 어떻게 실시하고 있는지 그 실태를 파악하는 것을 목적으로 하였다. 이를 위해 부산시내 소재의 생태유아교육기관, 레지오 교육기관, 몬테소리 교육기관과 국가수준의 교육과정을 오래전부터 수행하고 있는 국공립 유아교육기관, 10곳을 중심으로 부모교육 연간계획안 및 관련 문서자료들을 수집하고 원장과 교사를 중심으로 면담을 실시하였다. 계획, 내용, 실시, 평가 네 부분으로 범주화하여 설문지와 면담을 실시하였다. 부모교육은 각 기관의 원장의 교육신념과 철학에 큰 영향을 받고 있었으며 이와 함께 표준화된 평가기준과 누리과정이 부모교육 프로그램의 다양성과 각 기관이 갖는 철학적 고유성에 다소 부정적 영향을 미치고 있는 것으로 나타났다. 부모교육의 실시에서 교사들의 과중한 업무무담으로 부모교육은 또 하나의 행사로 자리매김하고 있었으며 부모들에게 현실적이면서 실질적인 도움을 줄 수 있는 부모교육이 이루어지기 어려운 실정이었다. 따라서 대부분의 기관에서 연간계획안의 문서상 프로그램과 현장에서의 구현은 상당히 달랐다. 현 실정에 맞는 부모교육에 대한 정책적 이해 및 실행이 절실히 요구되며 기관의 철학적 다양성과 지역적 특수성이 반영될 수 있는 방안이 함께 고려되기를 희망한다. This study compared parent education programs (PEP) and their actual implementations in 10 kindergartens and child care centers. We focused on four parts: 1)the planning of PEP, 2)the contents of PEP, 3)the implementation of PEP, and 4)the evaluation of PEP. For data collection, annual parent education plans and interview data were collected. The results showed that PEP was affected by the Nuri curriculum. The PEP in public education sectors was regarded as one of the administrative works. However Reggio and Early Childhood Eco Education programs showed us different story. They encouraged parent participation through PEP. PEP was regarded as important way of philosophy reflection. Through this study, we could see the pressure of the Nuri curriculum. Some child care centers come to lose their autonomy of application of their own educational perspectives. Therefore PEP was gradually considered as one of the administrative works that teachers have to write, not implement. We suggest that the Ministry of Education need to think deeply what will be going on in the education fields when everything is standardized.