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Shin, Ji‐,Ae,Kim, Jae‐,Jin,Choi, Eun‐,Sun,Shim, Jung‐,Hyun,Ryu, Mi Heon,Kwon, Ki Han,Park, Hee‐,Min,Seo, Jin‐,Young,Lee, Soo‐,Yeon,Lim, Do‐,Won,Cho, Nam Wiley Subscription Services, Inc., A Wiley Company 2013 Head & neck Vol.35 No.7
<P><B>Abstract</B></P><P><B>Background</B></P><P>The aims of this study were to evaluate the apoptotic activities and molecular mechanisms of methanol extracts of <I>Dianthus chinensis</I> (MEDC) and <I>Acalypha australis</I> L. (MEAL) in human oral cancer cells.</P><P><B>Methods</B></P><P>The apoptotic effects and related molecular mechanisms of MEDC and MEAL on oral cancer cells were evaluated using MTS assay, DAPI staining, immunostaining, Western blotting, and reverse transcriptase–polymerase chain reaction.</P><P><B>Results</B></P><P>Sp1 was overexpressed in oral tumor tissues compared with normal oral mucosa. Downregulation of Sp1 inhibited the growth of SCC‐15 and YD‐15 oral cancer cells. MEDC and MEAL inhibited cell growth and induced apoptosis in both cell lines by decreasing the expression of Sp1. In addition, treatment of cells with MEDC and MEAL decreased Mcl‐1 expression, which is a downstream target of Sp1.</P><P><B>Conclusion</B></P><P>Our results indicate that MEDC and MEAL are bioactive natural products that can potentially induce apoptosis of tumor cells that overexpress the Sp1 protein. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</P>
Interfacial energy level alignments between low-band-gap polymer PTB7 and indium zinc oxide anode
Shin, Dongguen,Lee, Jeihyun,Park, Soohyung,Jeong, Junkyeong,Seo, Ki-Won,Kim, Hyo-Joong,Kim, Han-Ki,Choi, Min-Jun,Chung, Kwun-Bum,Yi, Yeonjin JAPAN SOCIETY OF APPLIED PHYSICS 2015 Applied physics express Vol.8 No.9
Autoacetylation regulates differentially the roles of ARD1 variants in tumorigenesis
SEO, JI HAE,PARK, JI-HYEON,LEE, EUN JI,VO, TAM THUY LU,CHOI, HOON,JANG, JAE KYUNG,WEE, HEE-JUN,AHN, BUM JU,CHA, JONG-HO,SHIN, MIN WOOK,KIM, KYU-WON Spandidos Publications 2015 International journal of oncology Vol.46 No.1
Seo, Jang-Won,Lee, Soong,Shin, Byung-Chul,Park, In-Hyung,Han, Min-Seok,Lim, Jae-Kyu,Lee, Hyun-Min,Son, Seung-Cheol,Park, Chan-Guk 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
The idiopathic hypereosinophilic syndrome is characterized by the presence of over 1500 eosinophils per microliter of peripheral blood for 6 months or longer; lack of evidence for parasitic, allergic, or other known causes of eosinophilia; and signs or symptoms of multisystem organ dysfunction. The case of idiopathic hypereosinophilic syndrome with chest wall muscle infiltration in Korea is not reported yet. Here we report a case of suspected idiopathic hypereosinophilic syndrome presenting as a chest wall muscle infiltration and liver, lung involvement with a review of the relevant literatures. The patient was a 50-year-old female who presented left chest wall mass. The laboratory findings showed white blood cells 13,820/μL and eosinophil 8070/μL. The subpleural nodular consolidation was detected in ultrasonogarphy and computed tomography of chest. It was about 2.5×2 cm sized and had irregular margin with ill defined peripheral ground glass opacity on the superior segment of left upper lung. And 2.2×1.5 cm sized low attenuated nodular lesion with mild enhancement in liver (S7) were observed on the abdomnal computed tomography and ultrasonography. The sono guided-transthoracic needle aspiration of the lung revealed severe eosinophilic infiltration. As a result, the patient was suspected to have idiopathic hypereosinophilic syndrome with chest wall muscle infiltration.
Seo, Jeong-Sun,Lee, Ji Won,Kim, Ahreum,Shin, Jong-Yeon,Jung, Yoo Jin,Lee, Sae Bom,Kim, Yoon Ho,Park, Samina,Lee, Hyun Joo,Park, In-Kyu,Kang, Chang-Hyun,Yun, Ji-Young,Kim, Jihye,Kim, Young Tae American Association for Cancer Research 2018 CANCER IMMUNOLOGY RESEARCH Vol.6 No.7
<P>Subtypes of lung cancer are revealed by patterns of genomic alteration and immune infiltration. These patterns of mutation and immune cell presence could be used to guide choices of immunotherapy in a subtype-specific manner.</P><P>The immune microenvironment in lung squamous cell carcinoma (LUSC) is not well understood, with interactions between the host immune system and the tumor, as well as the molecular pathogenesis of LUSC, awaiting better characterization. To date, no molecularly targeted agents have been developed for LUSC treatment. Identification of predictive and prognostic biomarkers for LUSC could help optimize therapy decisions. We sequenced whole exomes and RNA from 101 tumors and matched noncancer control Korean samples. We used the information to predict subtype-specific interactions within the LUSC microenvironment and to connect genomic alterations with immune signatures. Hierarchical clustering based on gene expression and mutational profiling revealed subtypes that were either immune defective or immune competent. We analyzed infiltrating stromal and immune cells to further characterize the tumor microenvironment. Elevated expression of macrophage 2 signature genes in the immune competent subtype confirmed that tumor-associated macrophages (TAM) linked inflammation and mutation-driven cancer. A negative correlation was evident between the immune score and the amount of somatic copy-number variation (SCNV) of immune genes (<I>r</I> = −0.58). The SCNVs showed a potential detrimental effect on immunity in the immune-deficient subtype. Knowledge of the genomic alterations in the tumor microenvironment could be used to guide design of immunotherapy options that are appropriate for patients with certain cancer subtypes. <I>Cancer Immunol Res; 6(7); 848–59. ©2018 AACR</I>.</P>