Development of a Data Structure for Human Library Services

Seunghee Han(한승희),Hyewon Lee(이혜원) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.9

본 연구에서는 휴먼 라이브러리 서비스의 체계적 관리, 운영을 돕기 위해 휴먼 라이브러리 운영에 필요한 구성요소를 규정하고 이를 기반으로 휴먼 라이브러리 운영을 위한 데이터 구조를 제안하였다. 기존 연구에서 제안된 휴먼 라이브러리 구성요소인 ‘운영자’, ‘사람 책’, ‘사서’, ‘자원봉사자’ 이외에 본 연구에서는 ‘이용자’를 추가하여 총 5가지의 휴먼 라이브러리 운영을 위한 구성요소를 제안하였다. 그리고 이를 기반으로 ‘휴먼 라이브러리’, ‘휴먼 북’, ‘이용자’라는 3가지 메타 개념을 도출하였고, 도출된 메타 개념을 이용하여 휴먼 라이브러리 운영을 위한 메타데이터 세트를 개발하였다. 또한 메타데이터 세트의 타당성을 검증하고 활용성을 높이기 위하여 본 연구에서는 메타데이터 요소를 XML 문서로 선언하였으며, 메타 개념들을 연결하는 구조도 반영하였다. 본 연구의 결과를 통해 도서관에서는 이용자 프로파일 관리를 통해 이용자에게 휴먼북 추천 서비스를 제공하는 등 이용자 중심의 서비스를 개발할 수 있다. In this study, we suggested a data structure for the management of human libraries based on the analysis of the significant components for systematically managing and operating the human library service. At first, we proposed the components of human library metadata set which are Human Resource, Human Resource, Librarian, Volunteer, and ‘User’. And this study verified the meta concepts of metadata set such as Human Library, Human Book and User’, developed the metadata set for human library using the meta concepts. To check the validity of the metadata set and to improve its usability, we created and published a XML document including the metadata structure and link between the meta concepts. In conclusion, this study provided the possibility that the library could develop the service recommended human book to user through user profile.

The Scattering and Absorption Effects of Fluorescence Spectroscopy in a Real Time Optical Biopsy

Han, Seunghee,Muller, Markus G.,Kang, Seunghee,Kang, Haejin Korean Society of Medical Physics 2001 의학물리 Vol.12 No.1

생물학적 조직(Biological Tissue)에서 얻어내는 형광(Fluorescence)은 산란(Scattrering), 흡수(Absorption), 그리고 형광체(Fluorophores)가 원인이 되는, 인트린식 형광(Intrinsic Fluorescence)들에 관한 정보를 갖고 있다. 생물학적 조직의 형광스펙트럼은 조직 내에 존재하는 흡수체(Absorber)와 산란물질(Scatters)들의 영향을 받기 때문에 다른 조직의 생화학적인 인트린식 형광을 선형적인 조합으로 해석할 수 없었다. 생물학적 조직 같은 터비드 매질(Turbid Media)로부터 실험적으로 형광을 얻어서 산란과 흡수의 영향을 조사하기 위하여 본 연구소에서 제작한 장치를 소개하고, 넓은 범위의 흡수체와 산란물질의 농도를 갖고 제작한 조직 팬텀(Tissue Phantom)에 대한 형광과 반사(Reflectance) 스펙트럼을 측정하였다. 형광스펙트럼에 존재하는 산란과 흡수의 왜곡(Distortion)을 제거하기 위하여, 반사스펙트럼에 포함된 산란과 흡수 정보를 이용하는 ‘광자 이동 모델(Photon Migration Model)’을 적용하였고, 이러한 조직모델에 대한 인트린식 형광을 얻었다 연구 결과, 모델 값과 실제 인트린식 형광 스펙트럼이 훌륭하게 일치함을 확인하였다. 이런 연구를 하게된 동기는, 인간의 조직이 병들어서 진화하면 조직의 생화학적 구성의 변화가 발생하고 이때 인트린식 형광의 변화가 생기기 때문이다 결론적으로, 조직에 대한 실시간 광학적 생검에서 병든 조직과 정상조직을 단지 형광스펙트럼만으로 구분하는 것은 어렵지만, 인트린식 형광을 이용하면 가능하다. The fluorescence emanating from a biological tissue contains information about scattering, absorption and the intrinsic fluorescence (fluorescence only due to fluorophores). Becaue fluorescence spectra of biological tissue are often significantly affected by the presence of tissue absorbers and scatterers, the measured tissue fluorescence cannot be interpreted as a linear combination of intrinsic fluorescence spectra of different tissue biochemical. We conducted experiments to examine the influence of scattering and absorption on the experimentally measured fluorescence of a turbid medium such as biological tissue. Therefore, we acquired fluorescence and reflectance spectra of tissue phantoms with a wide range of scatterer and absorber concentrations. By applying a photon migration model, which uses the scattering and absorption information contained in reflectance spectra to remove their distortion also present in fluorescence spectra, we extract the intrinsic fluorescence of these tissue models. We achieved excellent agreement between modeled and actual intrinsic fluorescence spectra. The motivation for this research is that intrinsic fluorescence spectra are expected to change with progression of disease in human tissue, due to changes in the tissue biochemical composition. It is not possible to distinguish the two tissue types by using only the measured fluorescence, however clear separation can be achieved with the intrinsic fluorescence in real time optical biopsy.

Identical twin with discordant classification of pituitary adenoma, and different GNAS gene sequence

( Seunghee Han ),( Hye-sun Park ),( Ji-yeon Lee ),( Sehee Park ),( Cheol Ryong Ku ),( Dong Yeob Shin ),( Young Suk Jo ),( Sun Ho Kim ),( Eun Jig Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

The majority of pituitary adenomas are sporadic tumors with recognized genetic mutations seldom being found. And familial pituitary tumors account for about 5%, carrying germline mutations in predisposition genes, including MEN1, PRKAR1A, and AIP. But, about 85% of familial pituitary adenoma kindred have unknown genetic cause. Meanwhile, the concordant occurrence of pituitary adenoma in identical twins is extremely rare. This case which report different subtypes of pituitary adenoma occurred in identical twins could contribute to elucidate the tumorogenesis of pituitary adenoma. A 26-year-old woman visited hospital with amenorrhea for 1.5 years. Her initial serum prolactin level was 141.0 ng/mL. Sella magnetic resonance imaging (MRI) showed a 0.6 cm sized right pituitary adenoma. After transsphenoidal surgery, serum prolactin level normalized and her menstruation returned regularly. Her twin sister had acromegalic features, such as enlarged face, hands and feet. Basal serum insulin-like growth factor (IGF-1) levelwas 770.9 ng/mL. Sella MRI showed a 1.5 cm sized left pituitary adenoma.. Serum growth hormone (GH) level was not suppressed by 75g oral glucose tolerance test (OGTT). After tumor removal, serum GH level was suppressed by OGTT. Their pathologic results consisted with prolactinoma andgrowth hormone secreting tumor, respectively. In evaluating family history, their father’s brother had pituitary adenoma. Short tandem repeat (STR)analysis results consisted with identical twins. Because of their family history and early onset of pituitary adenoma, genetic test was done for determining familial pituitary adenoma. And, genetic alterations in sporadic pituitary tumor also evaluated, because different subtypes of pituitary tumor was occurred in identical twins. We found GNAS gene mutation only in acromegaly patient. But the primary oncogenic potential of GNAS mutations remains a matter of debate. Thus, a better understanding of the causative genes and the pathogenic mechanisms of pituitary tumorogenesis is needed to improve the diagnosis and management of pituitary tumor patients.

Paroxetine-induced Hypoglycemia in Type 2 Diabetic Patient

Seunghee Han,Hye-Sun Park,Yong-ho Lee,Byung-Wan Lee,Eun Seok Kang,Bong-Soo Cha 이화여자대학교 의과학연구소 2016 EMJ (Ewha medical journal) Vol.39 No.1

Selective serotonin reuptake inhibitors are commonly prescribed drugs for the treatment of depression in the patients with diabetes. Here, we report a case of paroxetineinduced severe recurrent hypoglycemia that developed in a 35-year-old woman with poorly controlled type 2 diabetes complicated by diabetic nephropathy and neuropathy. She discontinued her daily insulin therapy 2 months after the introduction of paroxetine, but hypoglycemic events were sustained. After discontinuation of paroxetine, no more hypoglycemic events occurred.

POLYMER SURFACE MODIFICATION WITH PLASMA SOURCE ION IMPLANTATION TECHNIQUE

Seunghee Han,Yeonhee Lee,Junghye Lee,Jung-Hyeon Yoon,Haidong Kim,Gon-ho Kim,Gunwoo Kim 한국표면공학회 1996 한국표면공학회지 Vol.29 No.5

Establishment of bioassay system for RNAi-based control of Frankliniella occidentalis

Seunghee Han,Kyungmun Kim,Juhyeon Kim,Si Hyeock Lee 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

Frankliniella occidentalis is a notorious polyphagous crop pest causing tremendous economic loss. It damages flowers and leaves of host plants and also carries severe plant viruses. During last few decades, it has spread to all continents via transport of plant materials. Following extensive use of insecticides to control F. occidentalis, it has developed high level of resistance due to its short life cycle and high reproductive potential. In this study, RNA interference (RNAi)-based bioassay system was developed to find an alternative control measure for insecticide-resistant population of F. occidentalis. A variety of genes involved in various physiological mechanisms were selected for the test of dsRNA potency (tubulin, v-ATPase, amylase, aquaporin etc.). Each bioassay unit made by 3D printing has a leaf disc placed on 150 ㎕ of 50 ng/ul dsRNA solution and 20 thrips. The mortality was checked, and the dsRNA and leaf disc were replaced every 24 h for 72 h. Of the 20 genes tesetd, tubulin, v-ATPase, and aquaporin showed 31, 38, 38 and 45% of corrected mortality at 72 h post-treatment, respectively. This result suggests the potential of these genes as candidate lethal genes for RNAi-based F. occidentalis control system.

Establishment of bioassay system for RNAi-based control of Frankliniella occidentalis

Seunghee Han,Kyungmun Kim,Juhyeon Kim,Si Hyeock Lee 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10

Return to Color Ⅲ

SeungHee HAN 한국색채학회 2014 International Invitation Exhibition of Color Works Vol.2014 No.-

Distribution and type of acetylcholinesterase in fat body of various insects

Seunghee Han,Sanghyeon Kim,Si Hyeock Lee 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.04

Recently, the existence of non-neuronal, soluble AChEs with non-classical functions, such as stress response and chemical defense, has been reported in both vertebrates and invertebrates. With this in mind, it is intriguing to hypothesize that fat body is a main tissue to express non-neuronal AChE at least in some insects. As an initial step for the systematic approach to investigate the distribution of non-neuronal AChEs in insect fat body and to elucidate their physiological functions, we have selected 12 different insect species across different orders and isolated fat body tissues from them. Then, the presence or absence of AChE and its solubility nature were determined by native polyacrylamide gel electrophoresis in conjunction with western blot analysis insect-specific AChE1 and 2 antibodies. Among 12 insects examined, soluble AChE1 was determined to be expressed in fat bodies of insects involving honey bees, brown plant hoppers, dynastid beetles, lice, etc, AChE2 in fruit flies, bed bugs, mealworm beetles. However, no AChE was detected in fat bodies of the remaining two species American cockroaches and dragonflies Our findings clearly show that AChE is widely distributed in the fat body tissue of diverse insect species. More extensive investigation on in a wider variety of insect species would be necessary to deduce the evolutionary origin of fat body-specific AChE, which would be the ancestor of AChE with non-neuronal function.

Plasma Source Ion Implantation - A Three Dimensional Ion Implantation Technique

Seunghee Han,Haidong Kim,Yeonhee Lee,Junghye Lee,Sue-Gene Kim 한국진공학회 1995 한국진공학회 학술발표회초록집 Vol.- No.-