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Wang, Zhensong,Wei, Lifang,Wang, Li,Gao, Yaozong,Chen, Wufan,Shen, Dinggang IEEE 2018 IEEE TRANSACTIONS ON IMAGE PROCESSING - Vol.27 No.2
<P>Segmenting organs at risk from head and neck CT images is a prerequisite for the treatment of head and neck cancer using intensity modulated radiotherapy. However, accurate and automatic segmentation of organs at risk is a challenging task due to the low contrast of soft tissue and image artifact in CT images. Shape priors have been proved effective in addressing this challenging task. However, conventional methods incorporating shape priors often suffer from sensitivity to shape initialization and also shape variations across individuals. In this paper, we propose a novel approach to incorporate shape priors into a hierarchical learning-based model. The contributions of our proposed approach are as follows: 1) a novel mechanism for critical vertices identification is proposed to identify vertices with distinctive appearances and strong consistency across different subjects; 2) a new strategy of hierarchical vertex regression is also used to gradually locate more vertices with the guidance of previously located vertices; and 3) an innovative framework of joint shape and appearance learning is further developed to capture salient shape and appearance features simultaneously. Using these innovative strategies, our proposed approach can essentially overcome drawbacks of the conventional shape-based segmentation methods. Experimental results show that our approach can achieve much better results than state-of-the-art methods.</P>
FINITE p-GROUPS WHOSE NON-ABELIAN SUBGROUPS HAVE THE SAME CENTER
Lifang Wang 대한수학회 2017 대한수학회지 Vol.54 No.4
For an odd prime $p$, finite $p$-groups whose non-abelian subgroups have the same center are classified in this paper.
FINITE p-GROUPS WHOSE NON-ABELIAN SUBGROUPS HAVE THE SAME CENTER
Wang, Lifang Korean Mathematical Society 2017 대한수학회지 Vol.54 No.4
For an odd prime p, finite p-groups whose non-abelian subgroups have the same center are classified in this paper.
FINITE p-GROUPS WHOSE NORMAL CLOSURES OF NON-NORMAL SUBGROUPS HAVE TWO ORDERS
Wang, Lifang Korean Mathematical Society 2022 대한수학회지 Vol.59 No.4
We describe the structure of finite p-groups in which all normal closures of non-normal subgroups have two orders for p > 2.
Tizoxanide induces autophagy by inhibiting PI3K/Akt/ mTOR pathway in RAW264.7 macrophage cells
Jiaoqin Shou,Mi Wang,Xiaolei Cheng,Xiaoyang Wang,Lifang Zhang,Yingchun Liu,Chenzhong Fei,Chunmei Wang,Feng Gu,Feiqun Xue,Juan Li,Keyu Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2
As the main metabolite of nitazoxanide, tizoxanide(TIZ) has a broad-spectrum anti-infective effect againstparasites, bacteria, and virus. In this study, we investigatedthe effects of TIZ on autophagy by regulating the PI3K/Akt/mTOR signaling pathway. RAW264.7 macrophage cellswere treated with various TIZ concentrations. Cell viabilityassay, transmission electron microscope, and immunofluorescencestaining were used to detect the biological functionof the macrophage cells, and the expression levels of theautophagy pathway-related proteins were measured by Westernblot. Results revealed that TIZ promoted the conversionof LC3-I to LC3-II, the formation of autophagy vacuoles,and the degradation of SQSTM1/p62 in a concentration- andtime-dependent manner in RAW264.7 cells. Treatment withTIZ increased the Beclin-1 expression level and inhibitedPI3K, Akt, mTOR, and ULK1 activation. These effects wereenhanced by pretreatment with rapamycin but attenuated bypretreatment with LY294002. In addition, the conversion ofLC3-I to LC3-II was observed in Vero, 293T, and HepG2cells treated with TIZ. These data suggested that TIZ mayinduce autophagy by inhibiting the Akt/mTOR/ULK1 signalingpathway in macrophages and other cells.
Lifang Zhang,Ning Li,Yan Wang,Jizhe Guo,Junfei Li 한국고분자학회 2014 Macromolecular Research Vol.22 No.6
Block aliphatic polyesters can be useful for medical and pharmaceutical applications. These materials canbe prepared by sequential ring-opening polymerization reactions. In this work, a set of poly(ε-caprolactone)-poly(Llactide)aliphatic polyester AB diblock copolymers and poly(L-lactide)-poly(ε-caprolactone)-poly(L-lactide) aliphaticpolyester ABA triblock copolymers were prepared by consecutive controlled ring-opening polymerizations. Ring-openingpolymerization of ε-caprolactone in the presence of 1-isopropyl-3-(4-methoxyphenyl) imidazol-2-ylidene and ethyleneglycol offered α,ω-dihydroxyl-terminate poly(ε-caprolactone). An array of poly(L-lactide)-poly(ε-caprolactone)-poly(L-lactide) triblock copolymers with controlled molecular weights and narrow molecular weight distributions wassynthesized using the telechelic poly(ε-caprolactone) samples as macroinitiators for the ring-opening polymerizationof L-lactide. 1H NMR and 13C NMR spectral data of copolymers showed the chemical structures without random placement. Meanwhile, the spectral data also indicated that this polymerization mechanism was in agreement with the activatedmonomer mechanism.
Permeability Anisotropy of Columnar Jointed Rock Masses
Lifang Zou,Weiya Xu,Guotao Meng,Yu Ning,Huanling Wang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.10
This paper investigated the anisotropic permeability of columnar jointed rock masses at Baihetan hydropower station in Southwest China. Discrete element analysis is conducted to evaluate the hydraulic Representative Elemental Volume (REV) size of jointed rock masses. It is found to be 5m×5m and it is seven times of the column length. Research shows that permeability tensor of the jointed rocks exists. The maximum principle permeability is 3.47 × 10−14 m2 and the minimum principle permeability is 1.39 × 10−14 m2. The direction of maximum principle permeability is 72 degrees anticlockwise from the positive x- axis direction, which is along the same direction of the column length. A continuum hydro-mechanical coupling analysis is carried out on water infill of a tailrace tunnel in columnar basalt. An equivalent anisotropic mechanical model is applied in the numerical simulation. Anisotropic deformation and anisotropic permeability characteristics are investigated under the condition that the angle between maximum principle stress axis and maximum principle permeability axis is 72 degrees. Results show that anisotropic seepage field has an effort on anisotropic deformation field.
Yan Wang,Jizhe Guo,Lifang Zhang,Junhua Bai,Jifang Niu,Lijuan Jiang,Junfei Li 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.7
We investigated the random copolymerization of ε-caprolactone and 2,2-dimethyltrimethylene carbonate [poly(CL-co-DTC)] promoted by various imidazolium-based carbenes, including 1-isopropyl-3-p-methoxyphenylimidazol-2-ylidene [Catalyst (1)], 1-isopropy-3-p-methylphenylimidazol-2-ylidene [Catalyst (2)], and 1-methyl-3-p-methoxyphenyl-imidazol-2-ylidene [Catalyst (3)], all of which are new types of unsymmetrical N-heterocyclic carbene catalysts. The reaction was carried out in the presence of benzyl alcohol (BnOH) as an initiator in tetrahydrofuran. By varying the experimental conditions and the monomer feed composition, poly(CL-co-DTC) with high yield and molecular weight was prepared using the binary system Catalyst (1)/BnOH as catalyst/initiator.1H NMR and differential scanning calorimetry (DSC) characterizations verified random structures of the polymer. GPC characterization further showed high molecular weights and narrow molecular weight distribution of the final product.
BEFS-PPARγ2 Cells Incubated with trans-11 C18:1 Exhibit More Beneficial Fatty Acid Synthesis
Tao Wang,이홍구,LiFang Wu,GuiXin Qin,Yujie Lou,Zewei Sun,Wei Guo,Jian Yang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.5
Responses of the PPARγ2 (an adipogenic lineage determinant) over-expressed immortalized bovine embryonic fibroblast cell line (BEFS-PPARγ2 cells) to trans-11 C18:1 (TVA) incubation were evaluated. BEFS-PPARγ2 cells were well differentiated. Stearoyl-CoA desaturase 1, an endoplasmic reticulum enzyme that can catalyze conversion of TVA into cis-9, trans-11 CLA, exhibited a significantly (p<0.05) higher mRNA expression after 4 h, compared with controls. Enzyme activity peaked, and was significantly (p<0.05) higher after 6 h, compared with controls. With extension of the incubation time, TVA absorption into cells was significantly (p<0.05) higher with significantly (p<0.05) more conversion into cis-9, trans-11 CLA, compared with shorter incubation times. TVA incubated cells exhibited significantly (p<0.05) higher levels of arachidonic, eicosapentaenoic, and docosahexaenoic acids than controls. BEFS-PPARγ2 cells can be used as a model system and TVA incubation is a good approach for research into cis-9, trans-11 CLA-fortified beef production.