담낭 및 간외담도계 악성종양의 방사선치료

김은석,최두호 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

From 1992 to 1998, 41 patients received therapy for primary cancers of the extrahepatic biliary system(seven gallbladder and 34 extrahepatic biliary duct). Chemotherapy was administered to 12 patients(29 percent). Fifteen patients(37 percent) also received postoperative radiotherapy. All patients received megavoltage external beam radiation therapy(range, 3000 to 5580 cGy; median, 5040 cGy). The median survival of all patients was 10 months. Median survivals according to treatment mode, radiation therapy only, chemotherapy with radiotherapy, and postoperative radiotherapy were 5, 15, and 13 months, respectively(p=0.0194). Another prognostic factors were age(p=0.0248), weight loss(p=0.0446), and performance status(p=0.0296). Local failure was 53%, distent metastasis was 26% and both are 21%. extent of survival, chemotherapy agent and new treatment modalities, as IORT(intraoperaive radiotherapy and intraluminal brachytherapy will be introduce.

蒐集 在來種 고추의 特性(1988年度)

金炳洙,李愚升,權寧石,孫銀鈴 慶北大學校 1989 論文集 Vol.48 No.-

Twenty three local cultivars of pepper(capsicum annuum L.) were planted in the Kyungpook National University Experiment farm and their growth and fruit characteristics were investigated. Seedings grown separately were tested for resistance to bacterial spot(Santhomonas campestris pv. vesicatoria) and Phytophthora blight(Phytophthora capsici) by artificial inoculation. KC209 was the earliest in flowering followed by KC218, KC203, KC223, KC202, KC201 and KC200. KC213, KC217, and KC204 were leading in fresh red fruit yield in a descending order among the rest excluding KC205 and KC207, open-pollinated fruits of which were removed and flower buds were wrapped before blooming to guarantee self-pollination. Fruits of Kc207 was the largest and Kc221 and KC217 were also bearing relatively large iruits. None of the cultivars tested was resistant to either bacterial spot or Phytophthora blight. Collection of local cultivars of pepper was continued in 1988 and 7 local cultivars were collected in Kyungpook, Cheonbuk, and Cheonnam provinces and their seed fruit characters were recorded.

수술후 재발한 자궁경부암의 방사선 치료 성적

김은석,최두호 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Surgical treatment is important modality for treatment of early stage uterine cervical cancer. But some of the cases may have treatment failure depending on the prognostic factors. Treatment of choice after locoregional recurrence is radiation modality. This is a retrospective analysis of 31 patients with locoregionally recurrent uterine cervix cancer with irradiation alone and/or palliative chemotherapy between August 1985 and July 1994. Fourteen patients had central (vaginal) recurrence and seventeen patients had other pelvic site recurrence. All patients had whole pelvis irradiation at least 50Gy and/or intracavitary radiotherapy(ICR). The results and conclusions are as follows. 1. Complete response was achieved in 16 patients (52%), 2 and 5 years survival rate were 38% and 13%, respectively. 2. Prognostic factors by univariate analysis were age, recurrence site, size of recurrent mass, ICR and response to treatment. Stage was marginally significant prognostic factor. By multivariate analysis, only size of recurrent mass was significant factor. 3. To increase control rate after recurrence, regular follow up after surgery and early detection of recurrence is important. 4. To decrease treatment failure, external radiotherapy and ICR is necessary and roles of other modalities including chemotherapy must be identified.

감염근관에서 Black-Pigmented Bacteria의 동정에 대한 연구

권은경,김은숙,곽주석,이황,이수종,임미경 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.1

Black-pigmented bacteria have been implicated in the endodontic infections. This group of microorganisms includes Porphyromonass endodontalis, Porphyromonas gingicalis, Prevotella intermedia, and Prevotella nigresceus. The organisms display a wide variety of virulence factors that may be pertinent to acute endodontic infections. The aim of this study was to identify P.endodontalis, P.gingivalis, P.intermedia, and P.nigrescens by using special potency disk test, filter paper spot test, 16S rRNA gene-directed PCR, and API 32A. Microbial samples were collected from root canals of 33 intact teeth with necrotic pulp and/or apical periodontitis. Conventional laboratory methods were used for identification of the strains of black pigmented bacteria. Eighteen of 33 samples were positive for the growth of black-pigmented bacteria. Five colonies were cultured from each pure cultured colonies from Brucella agar plate. Seventy seven colonies were positive for the growth of black-pigmented bacteria. Thirty three of 77(42.6%) were identifed as P.nigrescens, 10 of 77(12.9%) were P.gingivalis, 6 of 77(7.8%) were P.endodontalis, 10 of 77(12.9%) were P.intermedia. On the contraty the reference strains of P.nigrescens, experimental strains of P.nigrescens was sensitive to kanamycin in special potency disk test. 16S rRNA gene PCR and API test after rapid presumptative identification methods. such as special potency disk test and filter paper spot test, would be accurate detection methods for black-pigmented bacteria.

강유전성 BaTiO₃의 분극처리에 의한 유사체액 내에서 Calcium Phosphate 생성

송종은,김은주,황규석,임용무,박영준 대한치과기재학회 2000 대한치과재료학회지 Vol.27 No.4

Barium titanate (BaTiO3; BTO) has wide application in industry, particularly in the manufacturing of dynamic random access memory chips, electro-optical switches, optical modulators, shutters, optical mixers, and sensors, owing to its ferroelectric and piezoelectric properties after poling treatment. There has recently been considerable interest in the properties of its role in osseointegration. In this study, we investigated the possibility of treating BTO by poling to improve osseointegration by examining the calcium phosphate (Ca-P) crystal growth behavior on the poled and non-poled BTO surfaces in simulated body fluids (SBF). The BTO samples were sintered at 1350℃ for 2 h in air, producing an average grain size of 7 ㎛, which were confirmed by SEM observation. The sintered BTO samples were then polarized (Ep=5 kV/cm) from 160℃ to 25℃ in a Si oil bath for 2 h. The poled and non-poled BTO samples were immersed in 1.5 SBF for 15 days, or 30 days at 37℃. After the immersion period, the morphological and compositional changes of the surface of the immersed BTO specimens were investigated using a field emission scanning electron microscope (FE-SEM) and an energy dispersive X-ray spectrometer (EDX). Qualitative analysis was then performed using fourier transform infrared (FTIR) analysis. Weak and coarse Ca-P crystals had grown on the surface of the non poled BTO, while a marked difference in the Ca-P forming pattern was visible for the poled BTO, showing the negatively charged surface induces a Ca-P layer more easily. We assumed that rapidly adsorbed cations (Ca2+ ions) on the negatively charged surface at the initial stage acted as nuclei for the formation of Ca-P crystals, while no nuclei would be available on the positively charged surface, due to the fact that sodium chloride (NaCl) crystals were formed owing to anion adsorption (Cl ions). In summary, these results demonstrate that poling the ferroelectric BTO surface negatively the possibility of implant osseointegration.

한국인의 구강위생용품 사용실태에 관한 조사연구

서은주,신승철,서현석,김은주,장연수 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.2

The purpose of this study was to evaluate the actual state of Koreans' behavior about the use of oral hygiene devices and to collect the baseline data for developing appropriate educational objectives to improve dental health. Questionnaires were used to personally interview 1,685 residents in Korea. The obtained results were as fallows; 1. Average head size of toothbrushes was 23.2㎜ in children, 28.2㎜ im adults. 2. The averagep percent of using dentifrice containing fluoride at home was 66.7% in children, 71.4% in adults. 3. The average percent of using orthodontic toothbrushes was 50.5% in orthodontic patients, and the average percent of using interdental burshes was only 16.9% in orthodontic patients. 4. The average percent of using dental floss was 22.3% in periodontic patients, and the average percent of using interdental brushes was 16.5% in periodonitc patients. 5. The patients usually use oral hygiene devices by means of dentals' suggestions and commercial advertisement. 6. Generally few people use auxiliary oral hygiene devices. To improve the oral health starus effectively, more improved and correct informations and materials should be provide to dentists, dental hygienists and patients.

자궁경부암의 수술후 방사선치료 결과와 림프절 전이상태의 관련성에 관한 연구

최두호,김은석 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

This is a retrospective analysis of 124 patients with uterine cervix cancer who were treated with postoperative radiation therapy after radical hysterectomy and lymph node dissection between May 1985 and May 1994 at the Department of Radiation Oncology, Soonchunhyang University Hospital. The results were as follows. 1. Overall and relapse free 5 year survival rate were 75.4% and 73.5%, respectively. 2. The numbers and sites of lymph node metastasis were prognostic factors by univariate analysis. Also the lymph node dissection numbers in patients with lymph node metastasis negative were prognostic factor. 3. Treatment related failures were 33 cases, the majority of them (23 patients) were in patients with lymph node metastasis. 4. To control recurrence for patients with high risk lymph node metastasis, postoperative radiotherapy is not sufficient. This result suggests that additional radiosensitizing agent or chemotherapy may be necessary for higher disease control. Also this study suggests the " through dissection of lymph node " in patients with uterine cervix cancer instead of " a few lymph node sampling ".

핵연료 수송용기의 방사선 차폐해석

조건우,김희원,권석근,곽은호,문석형 대한방사선 방어학회 1985 방사선방어학회지 Vol.10 No.2

KSC-1 핵연료 수송용기에 대한 방사선차폐해석을 QAD-CG, ANISN-KA, DOT 3.5등의 전산코드와 DLC-23/CASK의 핵단면적 자료를 사용하여 수행하였다. 운반물인 사용후 핵연료집합체로부터 방출되는 중성자 및 감마선의 방사선원항은 ORIGEN-79전산코드를 이용하여 평가하였다. 방사선차폐해석 결과, 1개의 가압경수로 사용후 핵연료집합체를 운반할 수 있는 KSC-1핵연료 수송용기는 정상적인 수송조건에서 뿐만 아니라 가상적인 사고수송조건하에서도 관련 법령에서 정하는 기준을 만족하고 있어 방사선차폐해석의 관점에서 볼 때, 그 안전성이 입증된다. Radiation shield design for a shipping cask, KSC-1, was evaluated to verify that the cask can be used in the transportation of a spent fuel assembly discharged from KNU 5 & 6. Radiation source term of the spent fuel assembly was calculated with the computer program ORIGEN-79, QAD-CG, ANISN-KA and DOT 3.5 codes were used in the shielding calculations and the nuclear cross section data needed was extracted from the DLC-23/CASK library. It is concluded that KSC-1 shipping cask satisfies the requirements specified in the relevant regulations under normal conditions of transport and under accident conditions in transport.

내시경적 역행성 췌담관조영술중 췌선방 조영 후 발생한 중증 췌장염 1예

장세중,기승석,김훈일,신혜영,박장원,송은훈,태재웅 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

내시경적 역행성 담췌관조영술 후 발생한 급성췌장염의 발생인자로 여러 가지 인자들이 관여하지만 특히 담췌관조영술 시행 후 과도한 췌선방 조영화에 의한 중증의 췌장염 증례를 경험하였기에 보고하는 바이다 Endoscopic retrograde cholangiopancreatography (ERCP) has been considered as a valuable tool for the diagnosis and management of disease of the pancreas and biliary tree. Post-ERCP pancreatitis is the most frequent and clinically significant complication following ERCP. But a few complication associated with this procedure are unforeseeable. Specially, acinarization as a result of a careless cooperation between operator and assistant may be influenced in complications of ERCP. Severe post-ERCP pancreatitis is rare complication, and its prognosis will be poor. Therefore, careful process and good relationship between operator and assistant in ERCP may be prevented this complication, but is not clear. Neglect of acinarization may be resulted in more aggravation of pancreatitis. We have cared for one patient with severe post-ERCP pancreatitis with pseudocyst after water-soluble contrast media spreading into the acini (acinarization) via ERCP in resolving phase idiopathic pancreatitis.

티타늄 상에 강유전성 barium titanate 박막 형성과 분극처리에 의한 유사체액 내에서의 calcium phosphate 생성 증진

박영준,이용렬,황규석,김은주,임용무,이기헌 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.2

This study was performed to fabricate a ferroelectric barium titanate (BaTiO₃, BTO) thin film on Ti substrate and to evaluate the effect of poling treatment for the improvement of calcium phosphate (Ca-P) formation. BTO thin-film was spin-coated on Ti substrate by dipping-pyrolysis technique using coating sol obtained by mixing Ba-naphthenate and Ti-naphthenate as starting substances. Pre-heating temperature of the BTO thin film was performed at 500℃ because organic-solvent was completely volatilized without any crystal growth, and the final heat treatment was performed at 600, 650, 700, 750, 800, 850℃, respectively. By repeating the coating and pre-heating procedure gor 20 times, homogeneous thin film of 0.7㎛ thickness could be fabricated, and it performed well during the poling treatment without breakdown. The final heating treatment of the BTO thin film at 750℃ produced a homogeneous crystalline structure without heterogeneous TiO₂formation, which was confirmed by field emission scanning electron microscope (FE-SEM) and X-ray diffraction analyser (XRD). An average grain size of 20∼30 ㎚ were confirmed by SEM observation. The final heat-treated BTO thin-films were polarized (Ep = 5 V/㎛) from 160℃ to 25℃ in heating chamber for 2 h. The negatively poled BTO thin film (N-BTO), non-poled BTO thin film (BTO), Ti substrate (Ti), and 600℃ heat-treated Ti (Ti-O) were immersed in SBF and Eagle's MEM solution for 15 days at 37℃. After the immersion period, the morphological and compositional changes of the surfaces were investigated using a FE-SEM and an energy dispersive X-ray spectrometer (EDX). After immersion in simulated body fluid (SBF), sodium chloride (Nacl) crystals were formed on Ti, Ti-O, and BTO surfaces due to anion adsorption (Cl), while Ca-P crystals were formed on N-BTO surfaces. We assumed that rapidly adsorded cations (Ca²□ ions) on the negatively charged surface at the initial stage acted as nuclei for the formation of Ca-P crystals. In MEM, sodium chloride (NaCl) was formed on Ti, and Ca-P layer including NaCl was formed on Ti-O. Weak and sparse Ca-P layers were formed on BTO, while thick, homogeneous, and dense Ca-P layer was formed on N-BTO, which was confirmed by FE-SEM and EDX. These results demonstrated that introducing a N-BTO on Ti is an effective method for the improvement of Ca-P formation in SBF and MEM. In conclusion, negatively charged ferroelectric BTO thin-film on Ti would improve the possibility of implant osseointegration.