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Effect of blood pressure and glycemic control on the plasma cell-free DNA in hemodialysis patients
( Da Wun Jeong ),( Ju Young Moon ),( Young Wook Choi ),( Haena Moon ),( Kipyo Kim ),( Yu Ho Lee ),( Se Yeun Kim ),( Yang Gyun Kim ),( Kyung Hwan Jeong ),( Sang Ho Lee ) 대한신장학회 2015 Kidney Research and Clinical Practice Vol.34 No.4
Background: The plasma levels of cell-free DNA (cfDNA) are known to be elevated under inflammatory or apoptotic conditions. Increased cfDNA levels have been reported in hemodialysis (HD) patients. The aim of this study was to investigate the clinical significance of cfDNA in HD patients. Methods: A total of 95 patients on HD were enrolled. We measured their predialysis cfDNA levels using real-time EIF2C1 gene sequence amplification and analyzed its association with certain clinical parameters. Results: The mean plasma cfDNA level in the HD patients was 3,884 ± 407 GE/mL, and the mean plasma cfDNA level in the control group was 1,420 ± 121 GE/mL (P < 0.05). Diabetic patients showed higher plasma cfDNA levels compared with nondiabetic patients (P < 0.01). Patients with cardiovascular complications also showed higher plasma cfDNA levels compared with those without cardiovascular complication (P < 0.05). In univariable analysis, the cfDNA level was associated with 3-month mean systolic blood pressure (SBP), white blood cell, serum albumin, creatinine (Cr), normalized protein catabolic rate in HD patients. In diabetic patients, it was significantly correlated with SBP, hemoglobin A1c, and serum albumin. In multivariate analysis, SBP was the independent determinant for the cfDNA level. In diabetic patients, cfDNA level was independently associated with hemoglobin A1c and SBP. Conclusions: In patients with HD, cfDNA is elevated in diabetic patients and patients with cardiovascular diseases. Uncontrolled hypertension and poor glycemic control are independent determinants for the elevated cfDNA. Our data suggest that cfDNA might be a marker of vascular injury rather than proinflammatory condition in HD patients.
( Da Wun Jeong ),( Ju Young Moon ),( Sang Ho Lee ),( Yang Gyun Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Plasma levels of cell-free DNA (cfDNA) are elevated in various proin- fi ammatory or apoptotic conditions. Previously, increased cfDNA levels were reported during hemodialysis. However, there is limited data regarding its clinical relevance in HD patients. The aim of this study was to investigate the clinical signifi cance of cfDNA in patients on maintenance HD. Methods: A total of 95 ESRD patients on Hemodialysis for 49.6±52.4 months were enrolled, we measured the pre-dialysis cfDNA using real-time EIF2C1 gene sequence amplifi cation and analyzed the association with clinical parameters by dividing to cfDNA <2000GE/ml, 2000< cfDNA<3000GE/ml and >3000 GE/ml with underlying disease and higher cfDNA and baseline characteristics and clinical parameters with cfDNA. Results: The mean plasma level of cfDNA of HD patients was 2302.07±2177.52GE/ mL and the mean plasma level of cfDNA of control group was 1420.74±1216.44GE/ mL( p< 0.05). cfDNA levels were signifi cantly higher in patients with diabetes mellitus compared to non-diabetic patients (2214.5±2163.4 vs. 1452.6±1221.3GE/mL, respectively, p < 0.035). CfDNA was signifi cantly correlated with current HbA1c but not associated with those of other time points. Patients with previous history of cerebrovascular disease, hypertension had also higher levels of cfDNA. Among clinical parameters, systolic blood pressure, current WBC counts were signifi cantly correlated with the levels of cfDNA but there was no association with infi ammatory parameters of different time points. finally, other parameters of dialysis adequacy including KT/V, uric acid and Ca, Ca*P, hemoglobin, LDL, age, BMI were not associated with the plasma levels of cfDNA. Conclusions: Our results indicate cfDNA could be a potential biomarker of proin- fi ammatory or apoptotic milieu in maintenance HD patients. However, the underlying reasons for the release of cfDNA and its functional role in uremic condition should be further defi ned for its clinical application.
정다운,장미나,권채령,김동은,이인성,Jeong, Da Wun,Jang, Mina,Kwon, Chae-Ryung,Kim, Dong-Eun,Lee, In Seong 복식문화학회 2017 服飾文化硏究 Vol.25 No.5
Firefighting hoods protect the head, face, and neck areas of officials while they perform firefighting services. The purpose of this study is to investigate the head size of Korean firefighting officials in order to establish the dimensions necessary to construct firefighting hoods. A total of 98 male firefighting officials participated in this study and 11 body dimensions, necessary for the construction of firefighting hoods, were measured. The data collected from the firefighting officials were compared to the general adult male data from the Size Korea national anthropometric study. The heights, weights, head circumferences, head heights, and bitragion arcs of the firefighters were significantly larger than those of general adult males, which shows that firefighting officials generally have larger body and head sizes than general adult males. Based on the results of Pearson's correlation coefficients, head circumference and head height were judged to be the important measurements for the construction of the firefighting hoods. Thus, these two measurements were chosen as the basic dimensions of the cross tabulation analysis. As a result, head circumferences of 57.00~60.99cm and head heights of 23.00~25.99 cm were found to be important measurement ranges among the firefighters. This study is expected to be used as the basis for the creation of firefighting hoods that help to ensure the safe rescue activities for firefighting officials.
권채령 ( Chae-ryung Kwon ),장미나 ( Mina Jang ),정다운 ( Da Wun Jeong ),김동은 ( Dong-eun Kim ) 한국의류학회 2019 한국의류학회지 Vol.43 No.3
This study measured and analyzed male firefighters hand sizes as well as suggested data for developing firefighting gloves with a good fit. Accordingly, body dimensions related to the hand were measured for 100 male firefighters. Twenty-three measuring items related to the hand and lower arm were selected. The firefighters' measurement data were compared to general adult male measurements from the 6th Korean Anthropometric data to analyze the hand sizes characteristics of firefighters. As a result, height, hand circumference, hand breadth, wrist circumference, elbow-wrist length, forearm-fingertip length and firefighter weight were significantly larger than adult males. A correlation analysis for 23 items was conducted to select items used as standards for setting a size when manufacturing firefighting gloves. Hand length and circumference were selected as representative hand parts for making firefighting gloves. Cross analysis between hand length and circumference were conducted to find the section showing the highest distribution ratio. As a result, the highest sections were between 19cm and 21cm for hand circumference and between 18.5cm and 19.5cm for hand length, which may be suggested as the most important ranges.