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침구경락 음양론의 새로운 발전, 기능적 뇌 척주요법 FCST
인창식 ( Chang Shik Yin ),고형균 ( Hyeong Gyun Koh ),이영진 ( Young Jin Lee ),전세일 ( Sae Il Chun ),이영준 ( Young Jun Lee ) 대한경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.4
Objectives: Functional Cerebrospinal Therapy (FCST) is a new physiologic therapeutics developed in Korea as a meridian yinyang balance approach. The theory of yinyang balance has been at the core of health enhancement approach of meridian and acupuncture medicine ever since its start. Methods: Introductory overview of FCST is presented in relation with meridian yinynag balance theory. Results: As the temporomandibular joint (TMJ) and related tissues have direct interconnection with brainstem proprioceptive or motor systems and the face is where all the meridians converge, FCST applies a fine adjustment of the posture of TMJ as a treatment tool for neurologic conditions or meridian imbalances. Conclusions: Highly sophisticated diagnostic and therapeutic techniques to adjust various subset aspects of yinyang balance are developed within FCST, which is supposed to be one of major contributions to natural healing.
통증환자에서 턱관절 경락음양 균형치료의 경추정렬 개선효과
인창식 ( Chang Shik Yin ),이영준 ( Young Jun Lee ),이영진 ( Young Jin Lee ) 대한경락경혈학회 2007 Korean Journal of Acupuncture Vol.24 No.4
Objectives: Temporomandibular joint (TMJ) balance is known to be intricately integrated with nervous system, cervical spine, and meridian system balance. This retrospective study with one-group pretest-posttest design reviewed cervical spine imaging data to provide evidence of spinal alignment improving effect of TMJ balance treatment. Methods: Cervical spine imaging data including computed tomography and simple x-ray of 25 cases with painful condition were reviewed to explore any change in cervical alignment on wearing the intraoral device for TMJ balance treatment of functional cerebrospinal therapy. Results: Cervical spine alignment significantly improved on wearing the intraoral device. Conclusions: TMJ balance treatment improves cervical spinal alignment, which may be a firm basis to proceed with further research of TMJ balance therapy as a way of balancing the whole-body meridian system.
저주파 전기자극이 비만여성의 체구성성분과 신체둘레 및 체중조절에 미치는 영향
전승철,홍인선,정은영,장은재 동덕여자대학교 생활과학연구소 2007 생활과학연구 Vol.12 No.-
The purpose of this study was to investigate the effects of low frequency and aerobic exercise on body weight, fat mass, percent body fat (PBF), lean body mass (LBM), body circumference, resting metabolic rate(RMR), energy intakerEl), binge-eating disorder(BED), coping strategy indicator(CSI), respiratory exchange ratio(R), oxygen uptake and energy expenditure in twenty obese women. The subjects were divided into two groups : low frequency electrostimulation with aerobic exercise group(LFE + EX, n=11), aerobic exercise group(EX, n=9). Both of the experimental groups were trained for 8 weeks. The subjects in the aerobic exercise performed 60 min in about, three times per week at the low intensity. The low frequency electrostimulation treatment which done to LFE + EX group was accomplished to part of uper arm, back, abdomen, femur, waist, hip, calf for 30 min/day and 3 days/wk using a low frequency electric stimulator at the level of 60Hz and 200Hz. The body weight, fat mass, PBF, 8 site body circumference, BED and EI were significantly decreased, and RMR was significantly increased in the LFE + EX group. However, the EX group was significantly decreased only on 3 site body circumference (waist, low-thigh, call) after 8 weeks and another 3 site body circumference (chest, up-thigh, upper arm) were not altered after 8 weeks, however the levels of significance (.0543, .0556, .0540, respectively) were closed to P=.05 utilizing as the critical level for acceptance of hypotheses. And LBM was not altered after 8 weeks in the EX and LFE + EX group. The R was significantly decreased only on the level of 200Hz during the low frequency electrostimulation and oxygen uptake was significantly decreased both on the level of 60Hz and 200Hz during the low frequency electrostim ulation. The energy expenditure was not altered on the level of 60Hz and 200Hz during the low frequency electrostimulation, but the level of significance (.056) was closed to P=.05 utilizing as the critical level for acceptance of hypotheses. As this results, it is suggested that low frequency electrostim ulation with aerobic exercise is much more effective than only aerobic exercise in improving the body fat loss, health care and exercise capacity on the obese women.
Transcriptome analysis of male and female mature gonads of Japanese scallop Patinopecten yessonsis
Jun Ding,Dan Yang,Chao Yin,Yaqing Chang,Yan Dou,Zhenlin Hao 한국유전학회 2016 Genes & Genomics Vol.38 No.11
The Japanese scallop Patinopecten yessoensis is an important commercial culture shellfish in China and Japan. In addition to its commercial interest, it has also attracted much attention because of its value in studying sex determination and differentiation mechanisms. Herein, two transcriptome libraries from male and female gonads at maturing stage were constructed. The two libraries were paired-end sequenced using Illumina sequencing techniques. A total of 81,986,898 cleaned reads were obtained, and assembled into 29,897 unigenes by using Trinity software and removing redundancy. Compared with the public Swiss-Prot and NR databases by BlastX, 9354 unigenes were significantly matched to known unique proteins. As determined by GO annotation and KEGG pathway mapping, functional annotation of the unigenes uncovered diverse biological functions and processes. After comparing the two transcriptome libraries, 8652 upregulated and 2973 down-regulated genes were identified in the male gonads. According to annotation information, at least 30 genes related to sex determination and differentiation, such as Dmrt1, Sox9, fem1 and vasa, were identified and characterized. The expression patterns of the random eight genes were then validated by quantitative real-time PCR (qRT-PCR) suggesting the high reliability of RNA-Seq results. The study provides an archive for further studies of molecular mechanisms of bivalve sex determination and differentiation.
Risk factors affecting amputation in diabetic foot
Jun Ho Lee,Ji Sung Yoon,Hyoung Woo Lee,Kyu Chang Won,Jun Sung Moon,Seung Min Chung,Yin Young Lee 영남대학교 의과대학 2020 Yeungnam University Journal of Medicine Vol.37 No.4
Background: A diabetic foot is the most common cause of non-traumatic lower extremity amputations (LEA). The study seeks to assess the risk factors of amputation in patients with diabetic foot ulcers (DFU). Methods: The study was conducted on 351 patients with DFUs from January 2010 to December 2018. Their demographic characteristics, disease history, laboratory data, ankle-brachial index, Wagner classification, osteomyelitis, sarcopenia index, and ulcer sizes were considered as variables to predict outcome. A chi-square test and multivariate logistic regression analysis were performed to test the relationship of the data gathered. Additionally, the subjects were divided into two groups based on their amputation surgery. Results: Out of the 351 subjects, 170 required LEA. The mean age of the subjects was 61 years and the mean duration of diabetes was 15 years; there was no significant difference between the two groups in terms of these averages. Osteomyelitis (hazard ratio [HR], 6.164; 95% confidence interval [CI], 3.561−10.671), lesion on percutaneous transluminal angioplasty (HR, 2.494; 95% CI, 1.087−5.721), estimated glomerular filtration rate (eGFR; HR, 0.99; 95% CI, 0.981−0.999), ulcer size (HR, 1.247; 95% CI, 1.107−1.405), and forefoot ulcer location (HR, 2.475; 95% CI, 0.224−0.73) were associated with risk of amputation. Conclusion: Osteomyelitis, peripheral artery disease, chronic kidney disease, ulcer size, and forefoot ulcer location were risk factors for amputation in diabetic foot patients. Further investigation would contribute to the establishment of a diabetic foot risk stratification system for Koreans, allowing for optimal individualized treatment.
Yin, Jinlong,Oh, Young Taek,Kim, Jeong-Yub,Kim, Sung Soo,Choi, Eunji,Kim, Tae Hoon,Hong, Jun Hee,Chang, Nakho,Cho, Hee Jin,Sa, Jason K.,Kim, Jeong Cheol,Kwon, Hyung Joon,Park, Saewhan,Lin, Weiwei,Naka American Association for Cancer Research 2017 Cancer research Vol.77 No.18
<P>Inhibition of a cellular enzyme that blocks the conversion from nonmesenchymal to mesenchymal forms of glioblastoma may prevent recurrence and resistance to radiation therapy, the latter of which continues to pose a major clinical challenge.</P><P>Necrosis is a hallmark of glioblastoma (GBM) and is responsible for poor prognosis and resistance to conventional therapies. However, the molecular mechanisms underlying necrotic microenvironment-induced malignancy of GBM have not been elucidated. Here, we report that transglutaminase 2 (TGM2) is upregulated in the perinecrotic region of GBM and triggered mesenchymal (MES) transdifferentiation of glioma stem cells (GSC) by regulating master transcription factors (TF), such as C/EBPβ, TAZ, and STAT3. TGM2 expression was induced by macrophages/microglia-derived cytokines via NF-κB activation and further degraded DNA damage–inducible transcript 3 (GADD153) to induce C/EBPβ expression, resulting in expression of the MES transcriptome. Downregulation of TGM2 decreased sphere-forming ability, tumor size, and radioresistance and survival in a xenograft mouse model through a loss of the MES signature. A TGM2-specific inhibitor GK921 blocked MES transdifferentiation and showed significant therapeutic efficacy in mouse models of GSC. Moreover, TGM2 expression was significantly increased in recurrent MES patients and inversely correlated with patient prognosis. Collectively, our results indicate that TGM2 is a key molecular switch of necrosis-induced MES transdifferentiation and an important therapeutic target for MES GBM. <I>Cancer Res; 77(18); 4973–84. ©2017 AACR</I>.</P>