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Relative tumor density of soft tissue sarcoma in Korean population: A retrospective analysis
( Bo Bin Cha ),( Kyu Yeon Kim ),( Jin Seop Kim ),( Yeon Gu Choi ),( Gyoo Huh ),( Hyeon Jeong Park ),( Heun Joo Lee ),( Young Jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1
Background: Relative tumor density (RTD) has been a standard method to compare skin cancer distribution by anatomical sites. RTD is a flawless tool to analyze soft tissue sarcoma (STS), a group of heterogenous malignant neoplasms with whole-body distribution. Objectives: This study aims to analyze RTD of STS in Korean cohort and provide a solid foundation to approach STS from different body sites. Methods: The biopsy data of 40 patients and a total of 41 sarcoma lesions was analyzed. RTD was calculated by dividing the proportion of tumors at a defined anatomical site by the mean proportion of the skin surface area. Body was classified into four anatomical sites of head and neck, trunk, upper limbs, and lower limbs. Results: Mean age of 26 men and 14 women was 64 years. The most commonly diagnosed sites of 41 lesions were lower limbs (n=16, 39.0 %) and trunk (n=12, 29.3 %). The sites with the highest RTD were head and neck (n=11, 2.98) and lower limbs (n=16, 0.98). The most common tumor in head and neck area was cutaneous angiosarcoma (n=7, 63.6 %). In terms of tumor type, Kaposi’s sarcoma (n=14, 34.1 %) was the most common, followed by dermatofibrosarcoma protuberans (n=12, 29.3 %). Conclusion: The concept of RTD paves the way to approach soft tissue sarcomas which show histological and topographical complexity.
Bo Bin Cha,Won-Serk Kim,Young-Jun Choi 대한의학레이저학회 2023 MEDICAL LASERS Vol.12 No.1
The most common benign vascular tumor, pyogenic granuloma (PG), does not resolve spontaneously. While the treatment parameters used for pulsed dye lasers (PDLs) are well-known, no objective therapeutic endpoint associated with PDL therapy in PG has been established. In the current study, three cases of PG were treated with a PDL using a 7-mm spot size, 2-6 ms pulse duration, and radiant exposure of 7-9 J/cm2 with level 1 air cooling. Dermoscopic examination immediately after PDL treatment revealed that the therapeutic endpoints of PDL were a newly appearing dusky violaceous area, an expanding whitish homogeneous area, and a focal crusted rupture. The successful treatment of the lesions indicates the potential application of dermoscopy to determine therapeutic endpoints when treating PG with PDL.
( Bo Bin Cha ),( Kyu Yeon Kim ),( Jin Seop Kim ),( Yeon Gu Choi ),( Gyoo Huh ),( Hyeon Jeong Park ),( Heun Joo Lee ),( Young Jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-
Background: Relative tumor density (RTD) has been a standard method to compare skin cancer distribution by anatomical sites. RTD is a flawless tool to analyze soft tissue sarcoma (STS), a group of heterogenous malignant neoplasms with whole-body distribution. Objectives: This study aims to analyze RTD of STS in Korean cohort and provide a solid foundation to approach STS from different body sites. Methods: The biopsy data of 40 patients and a total of 41 sarcoma lesions was analyzed. RTD was calculated by dividing the proportion of tumors at a defined anatomical site by the mean proportion of the skin surface area. Body was classified into four anatomical sites of head and neck, trunk, upper limbs, and lower limbs. Results: Mean age of 26 men and 14 women was 64 years. The most commonly diagnosed sites of 41 lesions were lower limbs (n=16, 39.0 %) and trunk (n=12, 29.3 %). The sites with the highest RTD were head and neck (n=11, 2.98) and lower limbs (n=16, 0.98). The most common tumor in head and neck area was cutaneous angiosarcoma (n=7, 63.6 %). In terms of tumor type, Kaposi’s sarcoma (n=14, 34.1 %) was the most common, followed by dermatofibrosarcoma protuberans (n=12, 29.3 %). Conclusion: The concept of RTD paves the way to approach soft tissue sarcomas which show histological and topographical complexity.
Characterization of Echinostoma cinetorchis endoribonuclease, RNase H
Sung-Bin Lim,Seok Ho Cha,Seung Jegal,Hojong Jun,Seo Hye Park,Bo-Young Jeon,Jhang Ho Pak,Young Yil Bakh,Tong-Soo Kim,Hyeong-Woo Lee 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.4
Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis endoribonuclease (RNase H; EcRNH) and to elucidate its molecular biological characters. EcRNH consisted of 308 amino acids and showed low similarity to endoribonucleases of other parasites (<40%). EcRNH had an active site centered on a putative DDEED motif instead of DEDD conserved in other species. A recombinant EcRNH produced as a soluble form in Escherichia coli showed enzymatic activity to cleave the 3-O-P bond of RNA in a DNA-RNA duplex, producing 3-hydroxyl and 5-phosphate. These findings may contribute to develop antisense oligonucleotides which could damage echinostomes and other flukes.
김학빈(Kim Hak Bin),차성운(Cha Sung Woon),이보형(Lee Bo Hyoung) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
Microcellular foam can be developed by first saturating a polymer sample with a volatile blowing agent, followed by rapidly decreasing its solubility in the polymer. New measuring solubility system is necessary for more accurate prediction solubility because old method is not precise. Therefore in this paper, we proposed new measuring solubility system design using axiomatic design tool. An axiomatic design is very useful and powerful design method. A comparison with old studies shows this new equipment to be more efficient and precise than the ones based on weighting the gas-saturated polymer under ambient conditions.