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- 저자 : ( Bing Cong Chen ) (검색결과 4 건)
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Experimental Feasibility Research on a High-efficiency Cement-based Clay Stabilizer
Ma Cong,Chen Bing,Chen Longzhu 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.1
In many civil engineering constructions, soft clayey soils are often stabilized with Ordinary Portland Cement (OPC) whose production process is energy intensive and emits a large quantity of CO2. In this paper, an OPC-based clay stabilizer (CSCN) which contains some eco-friendly materials is studied to compare with OPC by investigating the mechanical properties of the stabilized clays. Microstructural and mineralogical studies using Scanning Electron Microscope (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) are performed to reveal the mechanisms controlling the development of the strength and modulus. The test results indicate that the compressive strength and secant modulus increase with increasing the content of CSCN and curing age. To achieve the equivalent improvement of the strength and modulus, much less CSCN is needed relative to OPC, which illustrates that CSCN can be a more effective and relatively eco-friendly clay stabilizer. The analysis on pH values and moisture consumption indicates that the hydration and pozzolanic reactions in CSCN-stabilized clays may be quicker than those in OPC-stabilized clays. The microstructural analyses confirm the formation of C-S-H gels in stabilized clays and the types of C-S-H gels are dependent upon the Ca/Si molar ratio according to EDX results. The types and amounts of new minerals in stabilized clays are the possible mechanisms controlling the enhancement of mechanical properties.
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A simple strategy to improve the sensitivity of probe molecules on SERS substrates
Sun, Chengbin,Chen, Tingkun,Ruan, Weidong,Jung, Young Mee,Cong, Qian,Zhao, Bing Elsevier 2019 Talanta Vol.195 No.-
<P><B>Abstract</B></P> <P>In this work, we report a simple strategy to improve the detection sensitivity as well as the spectral quality of probe molecules on surface-enhanced Raman scattering (SERS) substrates. On normal SERS substrates, due to the decreased absorption capacity and changes in the molecule orientations, SERS signals disappear when the analyte molecule concentrations reach a limit value. To solve this problem, the molecular template reagent (MTR) technique, a simple strategy based on SERS surface selection rules, is considered. By choosing the best MTR according to different samples, the effect of adjusting the molecular orientations of samples can be studied. In this process, 1-butanethiol, 1-hexanethiol, 1-octanethiol, 1-decanethiol, and 1-dodecanethiol, which are MTRs, are used to adjust the orientations of probe molecules under optimized conditions. The use of the MTR technique indicated that the limit of detection (LOD) of the probe molecules of p-aminobenzenethiol and 4-mercaptobenzoic acid on noble metal substrates showed an increase of one order of magnitude over the LOD of the pure probing molecule systems. Hence, the proposed method introduces a way to detect the molecules with an improved sensitivity at extremely low concentrations. The study corresponds to a proof-of-concept study of MTR-assisted SERS for SERS-based applications in ultrasensitive analyses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A novel strategy to improve sensitivity of probe molecules. </LI> <LI> Regulate target probe molecules into preferred orientations by molecular template reagent (MTR). </LI> <LI> The use of MTR technique indicated that the LOD of the probe molecules of p-aminobenzenethiol exhibited one order of magnitudes increased. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Wei Han,Cong Zhang,Xiao-jiao Gao,Hua-bing Wang,Fang Chen,Fang Cao,Yong-wei Hu,Jun Ma,Xing Gu,Hou-zhong Ding 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1
Purpose: Five members of the zinc finger of the cerebellum (ZIC) family—ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5—have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled. ZIC proteins in 241 pairs of breast tumors and corresponding normal tissues were investigated using immunohistochemistry and the clinicopathologic roles of proteins were analyzed using Pearson’s chi-square test. Kaplan-Meier curves and Cox regression analysis were also used to analyze the prognostic value of the ZIC proteins. In addition, 12 pairs of fresh-frozen breast tumors and matched normal tissues were used in the western blotting analysis and RT-qPCR. Results: Only ZIC1 expression in normal tissues was obviously higher than that in tumors (p<0.001). On multivariate analysis, ZIC1 expression (in overall survival analysis: hazard ratio [HR], 0.405, 95% confidence interval [CI], 0.233–0.702, p=0.001; in disease-free survival analysis: HR, 0.395, 95% CI, 0.234–0.669, p=0.001) was identified as a prognostic indicator of invasive breast cancer. Conclusion: ZIC1, but not the other proteins, was obviously decreased in breast tumors and associated with clinicopathologic factors. Thus, ZIC1 might be a novel indicator to predict the overall and disease-free survival of invasive breast cancer patients.
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