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        Sugar-Rich Food Intake Is Negatively Associated with Plasma Pentraxin 3 Levels

        Asako Zempo-Miyaki,Hiroshi Kumagai,Koichiro Tanahashi,Hirofumi Zempo,Takeshi Otsuki,Seiji Maeda 대한비만학회 2023 Journal of obesity & metabolic syndrome Vol.32 No.4

        Background: Levels of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, increase after weight loss in obese men and aerobic exercise in non-obese adults. However, the effect of nutritional characteristics on PTX3 levels remains unclear. This population-based, cross-sectional study investigated the association between circulating PTX3 levels and food intake in Japanese adults. Methods: We hypothesized that the consumption of high amounts of high-sugar foods would lead to low plasma PTX3 levels, resulting in obesity. This study included 327 participants categorized depending on the consumption of the recommended amount of confectionary and sugar-sweetened beverages (CSSB) into high and low groups. Results: PTX3 levels were significantly lower in the high CSSB group than in the low CSSB group. Biological sex was the strongest effector of PTX3 levels. Moreover, the intake of Tsukudani and CSSB, as well as some metabolic syndrome factors, also affect PTX3 levels. In the groups categorized by sex and age, the determinants of PTX3 levels differed. Body mass index, waist circumference (WC), and high-density lipoprotein cholesterol (HDL-C) were significantly associated with PTX3 levels in women. Tsukudani, HDL-C, heart rate, saturated fatty acids, systolic blood pressure, and CSSB were associated with PTX3 levels in individuals aged >65 years. Conclusion: Our results show that circulating PTX3 levels are affected by sex, sugar-rich foods, and metabolic syndrome characteristics (WC, HDL-C).

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        Curcumin supplementation attenuates the decrease in endothelial function following eccentric exercise

        최영주,Yoko Tanabe,Nobuhiko Akazawa,Asako Zempo-Miyaki,Seiji Maeda 한국운동영양학회 2019 Physical Activity and Nutrition (Phys Act Nutr) Vol.23 No.2

        [Purpose] Eccentric exercise induces a decrease in vascular endothelial function. Curcumin, a major component of turmeric, has potent antioxidant and anti-inflammatory properties that are associated with vascular protective effects. The present study examined the effect of acute supplementation of curcumin on eccentric exercise-induced endothelial dysfunction in healthy young men. [Methods] Fourteen healthy sedentary young men (range, 21–29 years) were assigned to either the curcumin (n = 6) or placebo (n = 8) group. All subjects consumed either curcumin or placebo before exercise, and eccentric exercise of the elbow flexors was performed with their nondominant arm. Before and 60 min after exercise, brachial artery flow-mediated dilation (FMD), as an indicator of endothelial function, was measured in the non-exercised arm. [Results] Brachial artery FMD significantly decreased following eccentric exercise (p < 0.05) in the placebo group, but acute supplementation with curcumin before exercise nullified this change. The change in FMD before and after eccentric exercise between the placebo and curcumin groups was significantly different (p < 0.05). [Conclusion] The present study found that acute curcumin supplementation could attenuate the decrease in endothelial function, as measured by FMD, following eccentric exercise in healthy young men.

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        Orignal Paper : High circulating Levels of oxidized LDL in strength-trained athletes

        ( Seiji Maeda ),( Young Ju Choi ),( Mutsuko Yoshizawa ),( Kai Tanabe ),( Asako Miyaki ),( Yoko Tanabe ),( Hitoshi Shiraki ),( Ryuichi Ajisaka ),( Hidehiko Komine ) 한국운동영양학회 2011 Physical Activity and Nutrition (Phys Act Nutr) Vol.15 No.2

        Oxidized low-density lipoprotein (oxLDL) has been shown to play a major role in the progression of atherosclerosis and cardiovascular disease. Aerobic exercise training has been reported to decrease plasma oxLDL levels. However, until now, there have been no studies regarding the effect of strength exercise training on plasma oxLDL levels. The purpose of this study was to investigate the plasma oxLDL. concentration and antioxidant capacity of plasma in strength-trained athletes. We specifically assessed the total scavenging activity against plasma hydroxyl radical (HO,) and alkoxyl radical (RO,) by using the electron spin resonance (ESR) technique, as both radicals are involved in oxLDL production. The subjects included young strength-trained athletes (SA group; shot put, hammer, javelin throwers, or power lifters; n=9) and sedentary individuals (control group; n=9). We measured plasma oxLDL concentrations and total scavenging activity against HO, and RO. Maximal muscle strength, as assessed by isokinetic tests of the knee and elbow joints and maximal handgrip strength, was significantly greater in the SA group than in the control group. Plasma oxl.DL concentrations were found to be significantly higher in the SA group than in the control group. The total scavenging activity of plasma against HO, and RO. did not differ between the two groups. These results suggest that high-intensity strength training increases plasma oxLDL concentration without upregulating the total scavenging activity against plasma HO, and RO.

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