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CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6
Lee, Eunhye,Lee, Taeyun A.,Kim, Ji Hyun,Park, Areum,Ra, Eun A.,Kang, Sujin,Choi, Hyun jin,Choi, Junhee L.,Huh, Hyunbin D.,Lee, Ji Eun,Lee, Sungwook,Park, Boyoun Oxford University Press 2017 Nucleic acids research Vol.45 No.6
<P><B>Abstract</B></P><P>The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide (LPS) induced <I>cnbp</I> expression through an NF-κB-dependent manner and a positive autoregulatory mechanism, which enables prolonged <I>il-6</I> gene expression. This event depends strictly on LPS-induced CNBP nuclear translocation through phosphorylation-mediated dimerization. Consequently, <I>cnbp</I>-depleted zebrafish are highly susceptible to <I>Shigella flexneri</I> infection <I>in vivo</I>. Collectively, these observations identify CNBP as a key transcriptional regulator required for activating and maintaining the immune response.</P>
Lee, Siyoung,Kim, Eunsom,Jhun, Hyunjhung,Hong, Jaewoo,Kwak, Areum,Jo, Seunghyun,Bae, Suyoung,Lee, Jongho,Kim, Busun,Lee, Jungmin,Youn, Sulah,Kim, Somi,Kim, Miyeon,Kim, Hyunwoo,Lee, Youngmin,Choi, Dong American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.28
<P>Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but mature INS was unable to induce an immune response. An affinity-purified rabbit polyclonal antibody raised against mature IL-1α recognized IL-1α and pINS but failed to detect mature INS and IL-1β. Analysis of the pINS sequence revealed the existence of an INS/IL-1α motif in the C-peptide of pINS. Surprisingly, the INS/IL-1α motif was recognized by monoclonal antibody raised against IL-1α. Deleting the INS/IL-1α motif in pINSd and IL-1α changed their activities. To investigate the pINSd receptor, the reconstitution of IL-1 receptor 1 (IL-1R1) in Wish cells restored pINSd activity that was reversed by an IL-1R antagonist. These data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1.</P>
Suicidal Ideation of the Elderly According to Their Involvement in Grandchild Care
Jeewon Lee,Areum Lee,Doeun Lee,Han-Young Jung,Shin-gyeom Kim,Soyoung Irene Lee 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.8
The purpose of the present study was to examine the severity of suicidal ideation of the older adults according to the amount of involvement in grandchild care. Data for this research were drawn from a cross-sectional study conducted on community-dwelling adults aged 65 years or older. The 922 participants were divided into three groups according to their involvement in grandchild care: 18.5% had provided daily care, 12.4% had provided occasional care, and 69.1% had never cared for their grandchildren. ANCOVA analysis showed that the scores for depression was significantly lower in the group which took care of their grandchildren occasionally compared to the other two groups. The scores for suicidal ideation was significantly higher in the group which had never taken care of their grandchildren compared to the other two groups. Current study suggests that grandparenting may have a positive effect on suicidal ideation of the older adults.
Impact of sleep restriction on the structural brain network
Lee, Min-Hee,Lee, Youngjin,Hwang, Yoon Ho,Min, Areum,Han, Bong Soo,Kim, Dong Youn Wolters Kluwer Health | Lippincott Williams Wilkin 2016 NEUROREPORT - Vol.27 No.18
<P>Sleep restriction (SR) is defined as the condition of not having enough sleep, and it can cause brain injury. In this study, we examined the impact of SR on the structural brain network. We obtained diffusion MRI (dMRI) data for the SR group of fourteen participants who got less than or equal to 5.5 h of sleep for the last 1 month and normal group of the same number of participants who got 7 h of sleep. We constructed the structural brain networks from the dMRI data and analyzed them using graph theoretical approaches. In comparison with the normal group, the SR group showed higher vulnerability to the targeted node attack and alterations of regional efficiency in the brain regions such as the bilateral orbital part of the frontal gyri, superior occipital gyri, left insula, fusiform, right supplementary motor area, and cingulate gyrus. These findings indicate that SR may cause the reduction of the potential alternative neuronal pathways in the brain and rewiring of neuronal fibers in the structural brain networks, which may result in potential functional impairments, as well as alterations of the structural brain connectivity. Therefore, investigating the structural brain network offers new insight into how SR influences the human brain. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.</P>
Lee, Hye Moon,Choi, Si‐,Young,Jung, Areum,Ko, Seung Hwan WILEY‐VCH Verlag 2013 Angewandte Chemie Vol.125 No.30
<P><B>Tragbare elektronische Bauteile</B> erfordern sehr leitfähige faserförmige Materialien, die nun bei Raumtemperatur hergestellt werden können. In der Zuschrift auf S. 7872 ff. stellen H. M. Lee, S. H. Ko et al. das Imprägnieren und Beschichten von Baumwoll‐ oder Papierfasern mit Al‐Atomen mithilfe der Vorstufe Al{O(C<SUB>4</SUB>H<SUB>9</SUB>)<SUB>2</SUB>} vor. Die Materialien weisen eine ausgezeichnete elektrische Leitfähigkeit und mechanische Haltbarkeit auf, was auf den möglichen Einsatz in elektrischen Schaltungen für flexible und tragbare elektronische Bauteile hinweist.</P>
Lee Jeewon,Kim Seong-Ju,Kim Dohyung,Yang Su-Jin,Lee Sangha,Lee Areum,Shin Yunmi 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.2
Objective The purpose of the present study was to develop and validate the Korean version of the clinician-administered KSADSCOMP, which is the recently updated, web-based computerized version of the Kiddie Schedule for Affective Disorders and Schizophrenia for school-age children (KSADS).Methods A total of 71 participants (mean age=12.04±3.86 years, female=29.57%) participated in the study. A child-adolescent psychiatrist established a diagnosis for the participant after a thorough psychiatric interview with the participant and the parent. Researchers who were blind to the diagnoses administered the clinician-administered KSADS-COMP to the parents and participants. The gold-standard diagnoses made by child-adolescent psychiatrists were compared to the current diagnoses generated by the clinician-administered KSADS-COMP. Percent agreement, Cohen’s Kappa, Gwet’s first-order agreement coefficient (AC1), sensitivity, specificity, positive predictive value, and negative predictive value were calculated.Results Gwet’s AC1, our preferred measure of agreement, showed excellent range between 0.78 and 1. Sensitivity, specificity, positive predicted value and negative predictive value also showed high scores.Conclusion The current study demonstrated excellent criterion validity of the Korean version of the clinician-administered KSADSCOMP, though the small sample size could be a limitation. The current study was the first study to examine the criterion validity of the KSADS-COMP. Due to its readily usable format and efficient and accurate diagnostic process, widely-use of KSADS-COMP is expected.
Lee, Hongseuk,Kim, Areum,Kwon, Hyeok-Chan,Yang, Wooseok,Oh, Yunjung,Lee, Daehee,Moon, Jooho American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.43
<P>We demonstrated crystallization retardation of CH3NH3PbI3 thin film during single coating of precursor solution by simple addition of NaCl. NaCl was codissolved into a precursor mixture solution containing PbI2 and methylammonium iodide (MAI). Dissolved NaCl interacted with the PbI2 in solution and produced a stable intermediate phase, which was converted to a full coverage uniform perovskite absorber layer via reaction with MAI during a single spin-coating. The resulting planar-structure perovskite solar cell made from NaCl-supplemented precursor solution showed a 48% improvement in power conversion efficiency (PCE) (maximum value 15.16%) over the device fabricated without the additive. Our NaCl-supplemented single coating represents an easy approach to effectively obtain highly reproducible uniform performance at an overall position in 5 cm x 5 cm sized cells (divided into 20 subcells with an active area of 0.06 cm(2)) with average PCEs of 12.00 +/- 0.48%.</P>