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Kim, Jaehwan,Oh, Chil-Hwan,Jeon, Jiehyun,Baek, Yoosang,Ahn, Jaewoo,Kim, Dong Joo,Lee, Hyun-Soo,da Rosa, Joel Correa,Suá,rez-Fariñ,as, Mayte,Lowes, Michelle A.,Krueger, James G. Nature Publishing Group 2016 The Journal of investigative dermatology Vol.136 No.1
<P>Psoriasis is present in all racial groups, but in varying frequencies and severity. Considering that small plaque psoriasis is specific to the Asian population and severe psoriasis is more predominant in the Western population, we defined Asian <I>small</I> and <I>intermediate</I> plaque psoriasis as psoriasis subtypes, and compared their molecular signatures with classic subtype of Western <I>large</I> plaque psoriasis. Two different characteristics of psoriatic spreading—vertical growth and radial expansion—were contrasted between subtypes, and genomic data were correlated to histologic and clinical measurements. Compared to Western <I>large</I> plaque psoriasis, Asian <I>small</I> plaque psoriasis revealed limited psoriasis spreading, but IL-17A and IL-17-regulated pro-inflammatory cytokines were highly expressed. Paradoxically, IL-17A and IL-17-regulated pro-inflammatory cytokines were lower in Western <I>large</I> plaque psoriasis, while T cells and dendritic cells in total psoriatic skin area were exponentially increased. Negative immune regulators, such as CD69 and FAS, were decreased in both Western <I>large</I> plaque psoriasis and psoriasis with accompanying arthritis or obesity, and their expression was correlated with psoriasis severity index. Based on the disease subtype comparisons, we propose that dysregulation of T cell expansion enabled by downregulation of immune negative regulators is the main mechanism for development of large plaque psoriasis subtypes.</P>