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Hao Zhang,Jun Zhou,Guanghui Liu,Zongyi Guo 한국항공우주학회 2023 International Journal of Aeronautical and Space Sc Vol.24 No.5
The thermal interface of a modular microsatellite can be equated to a multi-layer structure which is used to transfer heat between modules to maintain the temperature in a healthy range. To describe the heat transfer process at the thermal interface, an improved one-dimensional RC heat transfer model based on a thermal–electric analogy is proposed, considering both three complex heat transfer modes (heat conduction, radiation, and convection) and thermal contact resistance to describe the temperature variation at the thermal interface. Then, the temperature response of the novel thermal interface with five layers of materials is solved using step temperature boundary conditions, and the obtained temperature response is compared with the models considering only heat conduction. The comparison results show that the temperature prediction accuracy of the proposed model increased by 4.1%. Finally, experiments are designed and compared with the simulation results, which verify the validity of the proposed model.
Haibin Qu,Zhonghua Li,Guimin Zhang,Zongyi Zhou,Songgu Wu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-
Crystal engineering is a radical method to modulate the physicochemical properties of the drugs to meetthe needs of the pharmaceutical industry. Examined herein are six axitinib solid-state forms, includinganhydrous forms (Ⅳand XLI), solvates (acetic acid, nitromethane and n-propanol), and cocrystal (nicotinamide). Comprehensive characterization containing morphology, hygroscopicity, solubility, fluorescenceand powder tabletability were performed. Calculations of lattice energy, packing coefficient andenergy framework rationalized the structure–property relationship of these six forms from the packinglandscape. This system illustrates that form IV and cocrystal improve the solubility of axitinib, but thehumidity stability is also decreased. Six crystal forms show polychromatic solid-state luminescence rangingfrom violet to indigo to green. Form IV and cocrystal with slip plane structures exhibited superior tensilestrength and compactibility than isotropic form XLI. Elusive form VI can be obtained by controllingthe humidity levels during desolvation of the solvate. This work not only realizes the regulation of betterphysicochemical properties of axtinnib for industrial manufacturing, but also provides a detailed understandingof the structure–property relationship of drugs in complex polymorphic systems.