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- 저자 : Zhuoneng Li (검색결과 4 건)
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Qiong Luo,Zhuoneng Li,Jun Yan,Fan Zhu,Ruo-Jun Xu,Yi-Zhong Cai1 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.4
Lycium barbarum polysaccharides (LBPs) are important functional constituents in red-colored fruits of L. barbarum (Guo Qi Zi, a well-known traditional Chinese medicinal plant commonly known as Goji berry or wolfberry). The influence of LBP on human prostate cancer cells was systematically investigated in vitro and in vivo. The in vitro effects of LBP on two cell lines (PC-3 and DU-145) were examined by using trypan blue exclusion staining, single-cell gel electrophoresis, flow cytometry, terminal dUTP nick-end labeling assay, and immunohistochemical assay (assessment of Bcl-2 and Bax expression). The in vivo effect of LBP on PC-3 cells was assessed in the nude mouse xenograft tumor model. The in vitro results showed that LBP can dose- and time-dependently inhibit the growth of both PC-3 and DU-145 cells. LBP caused the breakage of DNA strands of PC-3 and DU-145 cells; the tail frequency and tail length were significantly higher than that of control cells. LBP also markedly induced PC-3 and DU-145 cell apoptosis, with the highest apoptosis rates at 41.5% and 35.5%, respectively. The ratio of Bcl-2/Bax protein expression following LBP treatments decreased significantly with a dose–effect relationship, which suggested that LBP can regulate the expression of Bcl-2 and Bax to induce apoptosis of PC-3 and DU-145 cells. The in vivo experimental results indicate that LBP might significantly inhibit PC-3 tumor growth in nude mice. Both the tumor volume and weight of the LBP treatment group were significantly lower than those of the control group.
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Luo, Qiong,Li, Zhuoneng,Yan, Jun,Zhu, Fan,Xu, Ruo-Jun,Cai, Yi-Zhong The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.4
Lycium barbarum polysaccharides (LBPs) are important functional constituents in red-colored fruits of L. barbarum (Guo Qi Zi, a well-known traditional Chinese medicinal plant commonly known as Goji berry or wolfberry). The influence of LBP on human prostate cancer cells was systematically investigated in vitro and in vivo. The in vitro effects of LBP on two cell lines (PC-3 and DU-145) were examined by using trypan blue exclusion staining, single-cell gel electrophoresis, flow cytometry, terminal dUTP nick-end labeling assay, and immunohistochemical assay (assessment of Bcl-2 and Bax expression). The in vivo effect of LBP on PC-3 cells was assessed in the nude mouse xenograft tumor model. The in vitro results showed that LBP can dose- and time-dependently inhibit the growth of both PC-3 and DU-145 cells. LBP caused the breakage of DNA strands of PC-3 and DU-145 cells; the tail frequency and tail length were significantly higher than that of control cells. LBP also markedly induced PC-3 and DU-145 cell apoptosis, with the highest apoptosis rates at 41.5% and 35.5%, respectively. The ratio of Bcl-2/Bax protein expression following LBP treatments decreased significantly with a dose. effect relationship, which suggested that LBP can regulate the expression of Bcl-2 and Bax to induce apoptosis of PC-3 and DU-145 cells. The in vivo experimental results indicate that LBP might significantly inhibit PC-3 tumor growth in nude mice. Both the tumor volume and weight of the LBP treatment group were significantly lower than those of the control group.
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Low-Temperature Synthesis of Highly Efficient, Deep-Red Zn-Cu-In-Se/ZnSe Fluorescence Quantum Dots
Juan Yang,Jingling Li,Yanqing Zhu,Xueqing Xu,Xiudi Xiao,Bing Deng,Kaili Qin,Zhuoneng Bi,Shuaijun Chen,Gang Xu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.6
We report a facile synthesis method on CuInSe2 (CISe)-based quantum dots (QDs) by using tri-n-octylphosphine selenium (TOPSe) as selenide precursor, with assistance of oleylamine (OAm) and n-dodecanethiol (DDT). We demonstrate that the OAm and DDT jointly contribute to the formation of the low-temperature-decomposable metal-sulfide clusters, and promote the QD nucleation at relatively low temperature range of 180–200 ℃. Furthermore, to improve fluorescence property, Zn-doping and ZnSe coating are simultaneously carried out. The obtained deep-red ZnCISe/ZnSe QDs possess higher quantum yield of 65% at wavelength of 670 nm, which is in the best performance range ever reported. Then, we investigate the improvement mechanism, where the sufficient Zn replacement of In sites is the crucial factor. This modified core–shell structure provides two benefits, on the one hand, the enhancement on intrinsic defect-related recombination, and the other hand, the improved core–shell interface that reduces the nonradiative recombination.
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Kaili Qin,Jingling Li,Yanqing Zhu,Xueqing Xu,Xiudi Xiao,Bing Deng,Juan Yang,Zhuoneng Bi,Shuaijun Chen,Gang Xu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.8
Crystal structure control is so important to the fluorescence properties that each element should be considered carefully. In conventional synthesis of ZnxCd1-xS alloyed nanocrystals (NCs), most of studies focus on ligand–surface interaction on the formation of either zinc blende or wurtzite ZnxCd1-xS nanocrystals, instead of the reactant source. In this work, mixed crystal phase was found easily in ZnxCd1-xS alloyed NCs when reaction proceeded at high Zn/Cd source ratio condition. Therefore, we regulate the Zn/Cd ratio to obtain relative pure zinc-blende structure, and study the influence of structure change on the fluorescence properties. Further, we have proposed a two-step ZnS coating method to acquire ZnxCd1-xS/ZnS NCs with separated crystal-phase between core and shell. Compared with maximum QY of 81% for ZnxCd1-xS/ZnS NCs synthesized by conventional one-step coating method, the performance of the optimized NCs has significantly improved with maximum QY of 93%.
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