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Nucleomodulin BspJ as an effector promotes the colonization of Brucella abortus in the host
Zhongchen Ma,Shuifa Yu,Kejian Cheng,Yuhe Miao,Yimei Xu,Ruirui Hu,Wei Zheng,Jihai Yi,Huan Zhang,Ruirui Li,Zhiqiang Li,Yong Wang,Chuangfu Chen 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1
Background: Brucella infection induces brucellosis, a zoonotic disease. The intracellular circulation process and virulence of Brucella mainly depend on its type IV secretion system (T4SS) expressing secretory effectors. Secreted protein BspJ is a nucleomodulin of Brucella that invades the host cell nucleus. BspJ mediates host energy synthesis and apoptosis through interaction with proteins. However, the mechanism of BspJ as it affects the intracellular survival of Brucella remains to be clarified. Objectives: To verify the functions of nucleomodulin BspJ in Brucella's intracellular infection cycles. Methods: Constructed Brucella abortus BspJ gene deletion strain (B. abortus ΔBspJ) and complement strain (B. abortus pBspJ) and studied their roles in the proliferation of Brucella both in vivo and in vitro. Results: BspJ gene deletion reduced the survival and intracellular proliferation of Brucella at the replicating Brucella-containing vacuoles (rBCV) stage. Compared with the parent strain, the colonization ability of the bacteria in mice was significantly reduced, causing less inflammatory infiltration and pathological damage. We also found that the knockout of BspJ altered the secretion of cytokines (interleukin [IL]-6, IL-1β, IL-10, tumor necrosis factor-α, interferon-γ) in host cells and in mice to affect the intracellular survival of Brucella. Conclusions: BspJ is extremely important for the circulatory proliferation of Brucella in the host, and it may be involved in a previously unknown mechanism of Brucella's intracellular survival.
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Baoping Zhang,Yun Liu,Zhongchen Ma,Meichen Guo,Bowen Shen 한국고분자학회 2018 Macromolecular Research Vol.26 No.2
The chemically modified lignin was synthesized based on rice straw and the adsorption properties of AuCl4 - were investigated in this paper. The adsorbent was characterized by Fourier transform infrared spectrometer, scanning electronic microscope and thermogravimetric analysis and differential scanning calorimetry. The chemically modified rice straw lignin was of excellent thermal stability and had plenty of primary amines and hydroxyls. Many influence factors such as initial concentration of AuCl4 -, adsorption time and concentration of hydrochloric acid on AuCl4 - were optimized. The maximum adsorption capacity was 783.94 mg·g-1. The equilibrium adsorption time was 600 min. The equilibrium isotherm fitted well with the Langmuir model and the pseudo-second-order kinetic model was suitable for describing the adsorption of AuCl4 -. Low hydrochloric acid concentration could promote the selectivity of adsorption on AuCl4 -. Combination of ion exchange and reduction was the mechanism. AuCl4 - was adsorbed by ion exchange first and then reduced from hydrochloric acid medium in the form of Au(0) by phenolic hydroxyl.
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