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상전장,Ueda, Takumi,Zhdanov, Michael S. Korean Society of Earth and Exploration Geophysici 2008 지구물리와 물리탐사 Vol.11 No.1
In this paper we consider an application of the method of electromagnetic (EM) migration to the interpretation of a typical marine controlled-source (MCSEM) survey consisting of a set of sea-bottom receivers and a moving electrical bipole transmitter. Three-dimensional interpretation of MCSEM data is a very challenging problem because of the enormous number of computations required in the case of the multi-transmitter and multi-receiver data acquisition systems used in these surveys. At the same time, we demonstrate that the MCSEM surveys with their dense system of transmitters and receivers are extremely well suited for application of the migration method. In order to speed up the computation of the migration field, we apply a fast form of integral equation (IE) solution based on the multigrid quasi-linear (MGQL) approximation which we have developed. The principles of migration imaging formulated in this paper are tested on a typical model of a sea-bottom petroleum reservoir.
1차원 이외의 배경 전기전도도 구조에서 근사 적분방정식을 이용한 3차원 전자탐사 모델링
이성곤,Michael S. Zhdanov 한국지구물리탐사학회 2005 지구물리와 물리탐사 Vol.8 No.3
이 연구에서는 배경 전기전도도 구조가 1차원 층서구조가 아닌 경우에도 적분방정식법을 이용하여 비교적 정확히 모델링 할 수 있는 근사적 방법에 대한 유도 과정을 제시하였으며, 이를 기반으로 전자탐사 수치 모델링을 구현하여 그 정확도 및 효율성에 대해 고찰하였다. 이 연구에서 제시된 방법은 통상적인 적분방정식법과 마찬가지로 1차원 층서구조에서의 Green 함수를 그대로 이용할 수 있어 계산 측면에서 매우 효율적이며, 대체적으로 적분방정식을 구성하기 위한 행렬의 크기를 줄일 수 있다. 본 연구에서 개발된 근사 적분방정식 알고리듬을 간단한 수치 모델에 대하여 적용한 결과 정확도는 반응을 구하고자 하는 이상체 부근에서는 거의 차이가 없었으며, 또한 계산 시간에 대한 분석을 통해 이 모델링 알고리듬을 이용하여 역산을 수행하고자 할 때 계산 시간을 대폭 감소시킬 수 있음을 확인하였다. 본 연구에서 제안된 방법은 1차원 층서구조가 아닌 이미 알려진 공통된 구조를 갖는 여러 지질 모델에 대한 전자탐사 반응을 매우 효율적으로 구할 수 있을 것으로 판단된다.
( Jeong Heo ),( Lai Wei ),( Konstantin Zhdanov ),( Eduard Burnevich ),( I-Shyan Sheen ),( Van Kinh Nguyen ),( Tawesak Tanwandee ),( Pin-Nan Cheng ),( Do Young Kim ),( Won Young Tak ),( Svetlana Kizhlo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis C virus (HCV) contributes significantly to the overall liver disease burden in the Asia Pacific region and Russia where the seroprevalence rates vary from 1-5% and genotype (GT) 1b accounts for about half of infections. The efficacy and safety of the fixed-dose combination of elbasvir (EBR) 50 mg and grazoprevir (GZR) 100 mg has been demonstrated in a broad population of HCV-infected subjects and supports evaluation in this region where clinical experience with direct-acting antivirals is limited. EBR/GZR is approved in the United States for treatment of HCV GT1 and 4 infection. Methods: C-CORAL is a double-blind placebo-controlled, Phase 3 trial that randomized treatment-naïve HCV GT1, 4 or 6 infected subjects in a 3:1 ratio to an immediate treatment group (ITG; 12 wks of EBR/GZR) or deferred treatment group (DTG; 12 wks of placebo, followed by 12 wks of EBR/GZR). Subjects were enrolled in an ex-China cohort that included subjects from Korea, Taiwan, Vietnam, Thailand, Australia, and Russia; and a second cohort enrolled subjects from China. The primary endpoints include the % of patients in the ITG who achieved SVR12 and a comparison of the safety and tolerability of EBR/GZR in the ITG vs placebo in the DTG. We will present the efficacy results of the ITG and safety results of the ITG and DTG in both cohorts. Results: To date, data from the ex-China cohort are available. In this cohort, a total of 250 subjects were enrolled in the ITG and 86 in the DTG. Mean age (±SD) was 50 ±12 years, 57% were females, 59% were Asian, 74% were GT1b, and 19% were cirrhotic. SVR12 in the ITG was 92.8% (table). Eighteen subjects in the ITG did not achieve SVR12: 11 were relapses, 6 were on-treatment failures (all GT6) and 1 GT1b subject withdrew consent. The incidence of adverse events (AEs) was generally comparable between the ITG vs the DTG including drug-related AEs (21.2% vs 19.8%) and serious AEs (0.8% vs 1.2%; none considered drug-related). During treatment with EBR/GZR or placebo 2/250 (0.8%) subjects in the ITG and 11/86 (12.8%) subjects in the DTG had an ALT value >5x ULN and greater than baseline. One subject in the ITG withdrew after meeting a trial specific discontinuation criterion for elevated ALT, which was not considered drug related. Updated safety and efficacy data will be presented for the ITG for both the ex-China and China study cohorts. Conclusions: A 12-week regimen of EBR/GZR is effective and well-tolerated in GT1 and GT4-infected, treatment-naïve patients in the Asia Pacific/Russia region.
( Do Young Kim ),( Lai Wei ),( Konstantin Zhdanov ),( Eduard Burnevich ),( I-Shyan Sheen ),( Jeong Heo ),( Van Kinh Nguyen ),( Tawesak Tanwandee ),( Pin-Nan Cheng ),( Won Young Tak ),( Svetlana Kizhlo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis C virus (HCV) contributes significantly to the overall liver disease burden in the Asia Pacific region and Russia where the seroprevalence rates vary from 1-5% and genotype (GT) 1b accounts for about half of infections. The efficacy and safety of the fixed-dose combination of elbasvir (EBR) 50 mg and grazoprevir (GZR) 100 mg has been demonstrated in a broad population of HCV-infected subjects and supports evaluation in this region where clinical experience with direct-acting antivirals is limited. EBR/GZR is approved in the United States for treatment of HCV GT1 and 4 infection. Methods: C-CORAL is a double-blind placebo-controlled, Phase 3 trial that randomized treatment-naive HCV GT1, 4 or 6 infected subjects in a 3:1 ratio to an immediate treatment group (ITG; 12 wks of EBR/GZR) or deferred treatment group (DTG; 12 wks of placebo, followed by 12 wks of EBR/GZR). Subjects were enrolled in an ex-China cohort that included subjects from Korea, Taiwan, Vietnam, Thailand, Australia, and Russia; and a second cohort enrolled subjects from China. The primary endpoints include the % of patients in the ITG who achieved SVR12 and a comparison of the safety and tolerability of EBR/GZR in the ITG vs placebo in the DTG. We will present the efficacy results of the ITG and safety results of the ITG and DTG in both cohorts. Results: To date, data from the ex-China cohort are available. In this cohort, a total of 250 subjects were enrolled in the ITG and 86 in the DTG. Mean age (±SD) was 50 ±12 years, 57% were females, 59% were Asian, 74% were GT1b, and 19% were cirrhotic. SVR12 in the ITG was 92.8% (table). Eighteen subjects in the ITG did not achieve SVR12: 11 were relapses, 6 were on-treatment failures (all GT6) and 1 GT1b subject withdrew consent. The incidence of adverse events (AEs) was generally comparable between the ITG vs the DTG including drug-related AEs (21.2% vs 19.8%) and serious AEs (0.8% vs 1.2%; none considered drug-related). During treatment with EBR/GZR or placebo 2/250 (0.8%) subjects in the ITG and 11/86 (12.8%) subjects in the DTG had an ALT value >5x ULN and greater than baseline. One subject in the ITG withdrew after meeting a trial specific discontinuation criterion for elevated ALT, which was not considered drug related. Updated safety and efficacy data will be presented for the ITG for both the ex-China and China study cohorts. Conclusions: A 12-week regimen of EBR/GZR is effective and well-tolerated in GT1 and GT4-infected, treatment-naive patients in the Asia Pacific/Russia region.
Computer modeling of a multi-run growth technique for sapphire ribbons
A.V.Borodin,V.A.Borodin,A.V.Zhdanov,I.S.Petkov 한양대학교 세라믹연구소 2003 Journal of Ceramic Processing Research Vol.4 No.2
Multi-run growth is most commonly applied to provide a high yield of shaped crystals. The presence of several crystals in a melting zone and a radiative heat exchange between them pose difficulties in the optimization of the heat zone design and growth conditions. The trial-and-error experiments can hardly be applied because of high cost in terms of materials and time. Moreover, the presence of many parameters under consideration and their interaction make a tentative search a very arduous task. In this paper, the multi-run growth process for sapphire ribbons is studied on the basis of mathematical modeling and the optimized relationships are found.