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RISS 인기검색어
- 검색키워드
- 저자 : Yu Fan Sim (검색결과 3 건)
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( Gwang Seong Choi ),( Woo Young Sim ),( Hoon Kang ),( Chang Hun Huh ),( Yang Won Lee ),( Sumitra Shantakumar ),( Yu Fan Ho ),( Eun Jeong Oh ),( Mei Sheng Duh ),( Wendy Y. Cheng ),( Priyanka J. Bobbil 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: 5α-reductase inhibitors are commonly prescribed for treatment of male androgenic alopecia (AGA). Objectives: To evaluate the long-term effectiveness and occurrence of adverse events (AEs) in AGA patients receiving dutasteride or finasteride. Methods: A retrospective medical chart review study was conducted across 5 hospital-based dermatology clinics in South Korea between Jan 2010 and Dec 2018. Males aged ≥ 18 years at initiation of dutasteride or finasteride for the treatment of AGA (index date) with ≥ 3 years of available follow-up information were included. Results: 295 (49%) and 305 (51%) AGA patients were prescribed dutasteride and finasteride respectively. Dutasteride patients were older and had higher severity at index than finasteride patients. During follow-up, improvement in hair growth was more frequently observed in dutasteride patients, as measured by improvements in BASP for the basic M and specific V types (adjusted IRR = 1.84 [p=0.031] and 1.95 [p=0.019], respectively). Proportions of AEs were equivalent (equivalence margin ±5%) or sometimes lower among dutasteride patients, including AEs of special interest (e.g., decreased libido, erectile dysfunction and ejaculation disorder, proportion difference = 0.7%). Conclusion: Over an observation period of 3 years, dutasteride demonstrated greater effectiveness than finasteride among men with the most common type of AGA (M type) across severity levels. Similar AE frequencies were observed across both drugs.
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Rodent peri-implantitis models: a systematic review and meta-analysis of morphological changes
Ren Jie Jacob Chew,Jacinta Xiaotong Lu,Yu Fan Sim,Alvin Boon Keng Yeo 대한치주과학회 2022 Journal of Periodontal & Implant Science Vol.52 No.6
Purpose: Rodent models have emerged as an alternative to established larger animal models for peri-implantitis research. However, the construct validity of rodent models is controversial due to a lack of consensus regarding their histological, morphological, and biochemical characteristics. This systematic review sought to validate rodent models by characterizing their morphological changes, particularly marginal bone loss (MBL), a hallmark of peri-implantitis. Methods: This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A literature search was performed electronically using MEDLINE (PubMed), and Embase, identifying pre-clinical studies reporting MBL after experimental peri-implantitis induction in rodents. Each study’s risk of bias was assessed using the Systematic Review Center for Laboratory animal Experimentation (SYRCLE) risk of bias tool. A meta-analysis was performed for the difference in MBL, comparing healthy implants to those with experimental peri-implantitis. Results: Of the 1,014 unique records retrieved, 23 studies that met the eligibility criteria were included. Peri-implantitis was induced using 4 methods: ligatures, lipopolysaccharide, microbial infection, and titanium particles. Studies presented high to unclear risks of bias. During the osseointegration phase, 11.6% and 6.4%-11.3% of implants inserted in mice and rats, respectively, had failed to osseointegrate. Twelve studies were included in the meta-analysis of the linear MBL measured using micro-computed tomography. Following experimental peri-implantitis, the MBL was estimated to be 0.25 mm (95% confidence interval [CI], 0.14–0.36 mm) in mice and 0.26 mm (95% CI, 0.19–0.34 mm) in rats. The resulting peri-implant MBL was circumferential, consisting of supra- and infrabony components. Conclusions: Experimental peri-implantitis in rodent models results in circumferential MBL, with morphology consistent with the clinical presentation of peri-implantitis. While rodent models are promising, there is still a need to further characterize their healing potentials, standardize experiment protocols, and improve the reporting of results and methodology.
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Rodent peri-implantitis models: a systematic review and meta-analysis of morphological changes
Ren Jie Jacob Chew,Jacinta Xiaotong Lu,Yu Fan Sim,Alvin Boon Keng Yeo Korean Academy of Periodontology 2022 Journal of Periodontal & Implant Science Vol.52 No.6
Purpose: Rodent models have emerged as an alternative to established larger animal models for peri-implantitis research. However, the construct validity of rodent models is controversial due to a lack of consensus regarding their histological, morphological, and biochemical characteristics. This systematic review sought to validate rodent models by characterizing their morphological changes, particularly marginal bone loss (MBL), a hallmark of peri-implantitis. Methods: This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A literature search was performed electronically using MEDLINE (PubMed), and Embase, identifying pre-clinical studies reporting MBL after experimental peri-implantitis induction in rodents. Each study's risk of bias was assessed using the Systematic Review Center for Laboratory animal Experimentation (SYRCLE) risk of bias tool. A meta-analysis was performed for the difference in MBL, comparing healthy implants to those with experimental peri-implantitis. Results: Of the 1,014 unique records retrieved, 23 studies that met the eligibility criteria were included. Peri-implantitis was induced using 4 methods: ligatures, lipopolysaccharide, microbial infection, and titanium particles. Studies presented high to unclear risks of bias. During the osseointegration phase, 11.6% and 6.4%-11.3% of implants inserted in mice and rats, respectively, had failed to osseointegrate. Twelve studies were included in the meta-analysis of the linear MBL measured using micro-computed tomography. Following experimental peri-implantitis, the MBL was estimated to be 0.25 mm (95% confidence interval [CI], 0.14-0.36 mm) in mice and 0.26 mm (95% CI, 0.19-0.34 mm) in rats. The resulting peri-implant MBL was circumferential, consisting of supra- and infrabony components. Conclusions: Experimental peri-implantitis in rodent models results in circumferential MBL, with morphology consistent with the clinical presentation of peri-implantitis. While rodent models are promising, there is still a need to further characterize their healing potentials, standardize experiment protocols, and improve the reporting of results and methodology.
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