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Youngchul Yoo,Jong Chan Park,Joo-Mi Yoon,Hyemin Lim,Gang-Seob Lee,Sang-Won Lee 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Plants have evolved a set of protecting mechanisms against pathogens, which include secondary metabolites and induced defense responses to pathogen attack. The biological role of purine alkaloids including caffeine is largely unknown. It has been proposed that caffeine confers a resistance against pathogenic bacteria and herbivores. We, in this study, tested direct effects on the growth of rice pathogenic microbes, Xanthomonas oryzae pv. oryzae (Xoo) causing a bacterial leaf blight and Magnaporthe grisea (M. grisea) causing a rice blast. Cell growth of Xoo and M. grisea were significantly retarded in presence of high concentration (2mM) of caffeine. Exogenous caffeine (5mM) induced resistance of wild type rice (cv. Dongjin, susceptible to Xoo and M. grisea) against those pathogens. These results indicated that caffeine enhanced the basal resistance to infection with Xoo. In addition, expression of pathogenesis-related (PR) genes was tested in the caffeine treated rice to elucidate the acquired resistance by caffeine, resulted in induction of PR genes including OsPR1a and OsPrb1. We have generated a transgenic rice producing caffeine by introduction of three N- methyltransferase genes (CaXMT1, CaMXMT1, CaDXMT1) identified from coffee plant. The transgenic rice successfully expressed the three genes, synthesized caffeine up to 5ug/g and showed enhanced resistance to Xoo. We also observed that transcripts of PR genes such as the OsPR1a and OsPrb1 encoding PR-1 type pathogenesis-related protein increased in the caffeine-producing rice. These result showed that caffeine is likely to act a powerful factor to increase level of rice defense as a natural and non-harmful metabolite.
Study of resistance in rice innate immunity by non-RD kinases
Youngchul Yoo,Jong-Chan Park,Joo-Mi Yoon,Min-Young Song,Chi-Yeol Kim,Jong-Seong Jeon,Sang-Won Lee 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Disease is one of the significant factors to damage for the crop productivity, including rice. Although there are many methods to avoid from several diseases such as chemical pesticides and biological treatments, it has been appreciated that the most economical and environmentally effective method of disease control is application of resistance genes. A survey (Dardick & Ronald, 2006) reported that plant kinome has a small number of non-RD kinase (nRDK) (4-29% of total kinase), all known or predicted pattern recognition receptors (PRRs) fall into the class. We here introduce a strategy to identify rice resistance genes that are probably encoding PRRs. We selected 130 nRDK genes by combinational analysis of QTL and bioinformatics, 61 of rice mutant lines of 130 candidates inoculated by Xanthomonas oryzae pv. oryzae (Xoo) and Magnaporthe grisea. (M. grisea), and disease progression was monitored. Lesion lengths of the activation mutant lines for nRDK-08 and nRDK-18 genes reduced more than 34% compared to wild type of rice (Dongjin) and other mutant lines. The nRDK-03 and nRDK-17 gene activation rice line had remarkably smaller lesion lengths by M. grisea infection. Our results suggest that a reverse genetic approach using bioinformatics and T-DNA tagging system successfully identified nRDK genes conferring a resistance against Xoo and M. grisea.
Effects of a newly developed tricyclic PARP-1 inhibitor, on ischemic stroke
Yoo, A. Rum,Koh, Seong-Ho,Noh, Min Young,Cho, Goang Won,Park, Ji-Seon,Kim, Youngchul,Lee, Han-Chang,Kim, Myung-Hwa,Kim, Seung Hyun Wiley Subscription Services, Inc., A Wiley Company 2010 Drug development research Vol.71 No.4
<P>Poly(ADP-ribose) polymerase (PARP)-1 plays an important role in the pathogenic mechanism of ischemic stroke. A number of studies have been undertaken to develop PARP-1 inhibitors for clinical use. We report on the newly developed PARP-1 inhibitors, among which 12a showed good activity (IC<SUB>50</SUB>=7.8 nM in an enzyme-based assay and=0.73 µM in a cell-based assay) and pharmacokinetic profiles. Treatment of the middle cerebral artery (MCA) occluded rats with 3 mg/kg 12a reduced infarct volume suggesting that, may be a good candidate for the treatment of ischemic stroke. Drug Dev Res 71: 253–260, 2010. © 2010 Wiley-Liss, Inc.</P>
망 관리 원시 코드 자동생성을 위한 ASN.1 개발 환경 설계 및 구현 (pp.826-835)
김영철(Youngchul Kim),김상헌(Sangheon Kim),최재영(Jaeyoung Choi),유재우(Chae-Woo Yoo),이동면(Dongmyun Lee) 한국정보과학회 1998 정보과학회 컴퓨팅의 실제 논문지 Vol.4 No.6
TMN에서는 망 관리에 필요한 운영체제와 통신 장비들에 이용되는 객체를 관리하고 정의하며, ASN.1은 이러한 객체들을 관리하기 위해 이용된다. 그러나 ASN.1 만으로는 망 관리에 직접적으로 이용할 수 없기 때문에 객체지향 패라다임을 가진 언어로 변환하여 이용하는 것이 효율적이다. 본 논문에서는 ASN.1 명세를 객체지향 언어인 C++로 자동적으로 변환하여 주는 원시 코드 자동 생성기를 설계하고 구현하였다. 이와 함께 ASN.1 개발환경에 필요한 그래픽 사용자 인터페이스, DB 인터페이스 및 ASN.1 브라우저를 포함하는 통합 환경을 제공한다. The network management in TMN defines and manages the objects which are used in the operating system and communication equipments in network. ASN.1 is used to describe those objects. ASN.1 cannot be directly used for managing network. It should be translated into a language with object-oriented paradigm. This paper presents the design and implementation of a translator which automatically translates the specification of ASN.1 to the object-oriented language C++. This system provides a total environment including for various graphic user interface, DB interface, browser to develop ASN.1 for development environment of ASN.1.
망 관리 원시코드 자동 생성를 위한 ASN.1 개발 환경 설계 및 구현 (pp.81-84)
변정섭(Jeongsub Byun),김영철(Youngchul Kim),김상헌(sangheon Kim),최재영(Jaeyoung Choi),유재우(Chaewoo Yoo) 한국정보과학회 1997 한국정보과학회 학술발표논문집 Vol.24 No.1A
본 논문에서는 망 관리를 위한 ASN.1 개발 환경에 대해서 설명한다. ASN.1 개발 환경은 ASN.1 명세 언어를 파싱하는 컴파일러 작업과, 컴파일 결과 생성된 자료들을 DB에 입력하고, 사용자에게 pretty printing하여 보여주는 작업이 필요하다. 본 논문의 구현은 Objectivity DB를 사용하였으며, 인터페이스로는 Tcl/Tk를 사용하였다.
윤의수(Euisoo Yoon),유일수(Ilsu Yoo),박무룡(Mooryong Park),황순찬(Soonchan Hwang),김수원(Suwon Kim),임영철(Youngchul Yim),오인균(Inkyun Oh),강민호(Minho Kang),최원철(Wonchul Choi) 한국추진공학회 2011 한국추진공학회 학술대회논문집 Vol.2011 No.11
한국기계연구원에서는 원자로냉각재펌프의 완전특성을 시험할 수 있는 시험 설비를 구축하였다. 이 설비는 유량은 최대 2,000 m3/hr, 동력은 최대 132 kW까지 펌프 및 수차의 시험이 가능하다. 본 논문에서는 완전특성 시험장치 및 시험방법, 이를 이용한 원자로냉각재펌프의 시험결과를 소개하고자 한다. An experimental test facility for the complete characteristics of pumps is constructed at KIMM(Korea Institute of Machinery and Materials). This paper describes the test facility and test technique of the complete characteristics of pumps, together with a experimental test result for a reactor coolant pump.
Sang-Wook Han,Mi-Ae Lee,Youngchul Yoo,Man-Ho Cho,Sang-Won Lee 한국식물병리학회 2019 Plant Pathology Journal Vol.35 No.1
Two-component systems (TCSs) are critical to the pathogenesis of Xanthomonas oryzae pv. oryzae (Xoo). We mutated 55 of 62 genes annotated as responsive regulators (RRs) of TCSs in the genome of Xoo strain PXO99A and identified 9 genes involved in Xoo virulence. Four (rpfG, hrpG, stoS, and detR) of the 9 genes were previously reported as key regulators of Xoo virulence and the other 5 have not been characterized. Lesion lengths on rice leaves inoculated with the mutants were shorter than those of the wild type and were significantly restored with gene complementation. The population density of the 5 mutants in planta was smaller than that of PXO99A at 14 days after inoculation, but the growth curves of the mutants in rich medium were similar to those of the wild type. These newly reported RR genes will facilitate studies on the function of TCSs and of the integrated regulation of TCSs for Xoo pathogenesis.