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단일 거대 간세포암의 수술적 절제 후 급격히 다발성 간외 전이가 진행된 1예
장은선 ( Eun Sun Jang ),김혜령 ( Haeryoung Kim ),최영록 ( Young Rok Choi ),조재영 ( Jai Young Cho ),윤유석 ( Yoo-seok Yoon ),한호성 ( Ho-seong Han ),김지현 ( Ji Hyun Kim ),김진욱 ( Jin-wook Kim ),정숙향 ( Sook-hyang Jeong ) 대한간암학회 2016 대한간암학회지 Vol.16 No.1
Hepatocellular carcinoma (HCC) shows a poor prognosis with high recurrence rate even after surgical resection. To improve prognosis of HCC patient, regular surveillance for high-risk group is recommended, but cost-benefit of the surveillance under 40 years old Asian male with hepatitis B infection is unclear. We share a 39-year-old male case which showed early recurrence and rapid extrahepatic metastasis after surgical resection for single huge HCC. Based on the pathologic finding, this case was diagnosed with ‘stemness’-related markerexpressing HCC. Further molecular classification for HCC could be beneficial to estimate individual risk for HCC recurrence and to predict prognosis. (J Liver Cancer 2016;16:42-46)
Primary hepatic choriocarcinoma in a female patient
Makhmud Malikov,Eun Shin(신은),Jai Young Cho(조재영),Ho-Seong Han(한호성),You-Seok Yoon(윤유석),Young Rok Choi(최영록),Jae Yool Jang(장재율),Hanlim Choi(최한림),Jae Seong Jang(장재성),Seong Uk Kwon(권성욱),Haeryoung Kim(김혜령) 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.1
Choriocarcinoma is a germ cell tumor belonging to the spectrum of gestational trophoblastic diseases, and occurs most commonly in the gonads. Primary hepatic choriocarcinoma is very rare, especially in females. A 59-year-old woman was referred to our clinic with a history of upper right quadrant pain lasting 1 month. Computed tomography and magnetic resonance imaging revealed a large hypervascular mass in the right liver, characteristic of angiosarcoma. The patient underwent right hemihepatectomy without unexpected events. Histopathology revealed the tumor as a choriocarcinoma, with numerous syncytiotrophoblasts. Immunohistochemistry was positive for β-human chorionic gonadotropin and CK-19, with a Ki-67 labeling index of 90%. The tumor showed focal positivity for CD31 and human placental lactogen. The patient started chemotherapy (vincristine and cyclophosphamide) on postoperative day 16. The patient’s clinical condition improved and she was discharged on postoperative day 17. Primary hepatic choriocarcinoma in female adults is a rare aggressive tumor, and further studies are needed to improve its diagnosis and treatment.