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- 저자 : Youguo Li (검색결과 2 건)
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Weijun He,Youguo Li,Sigen Ma 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.2
The Daliang zinc deposit occurs in the southwestern Xiangxi–Qiandong Zn-Pb metallogenic belt and is located on the southeastern margin of the upper Yangtze block. In this study, we present results from petrographic observations, rare earth elements, C-H-O isotopes, and fluid inclusions. The zinc deposit is hosted by middle Cambrian dolomite. The ore-forming process is divided into three stages from early to late: pyrite-galena, sphalerite-pyrite-dolomite, and dolomite. The characteristics of the REEs suggest that multiple fluids were involved in hydrothermal dolomite precipitation under low-temperature conditions. Two types of hydrothermal dolomite fluid inclusions were identified: pure liquid phase inclusions and liquid-rich phase inclusions. The fluid inclusions of hydrothermal dolomite yield homogenization temperatures of 108–192℃ (average 153℃), with salinities of 12.3–26.4 wt% (average 23.0 wt%) NaCl equiv. The δ13Cfluid, δDfluid and δ18Ofluid values for ore-forming fluids range from −4.2 to −3.5‰ (mean −3.8‰), −38.8 to −34.3‰ (mean −36.0‰), and 6.2–6.4‰ (mean 6.3‰), respectively. This study demonstrates that ore-forming fluid was sourced from a moderate- to high-salinity basinal brine and leached metals from metasedimentary rocks of the basement in the Yangtze block. The main transportation of ore-forming fluid occurred in the form of chlorine complexes along well-developed faults, and sulfides precipitated with decreases in pressure and temperature, as well as pH changes. Studies of the Daliang zinc deposit suggest that it is a mediumto low-temperature MVT-like deposit.
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Yan Zhu,Lijuan Yang,Jianqing Wang,Yan Li,Youguo Chen 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.6
Objective: Cisplatin resistance is a huge problem encountered in ovarian cancer treatment. Our study probed the roles and the underlying mechanisms of lncRNA MCF2L-AS1 in ovarian cancer cisplatin-resistance. Methods: SKOV3 and IGROV-1 cells were subjected to gradually increasing concentrations of cisplatin to construct ovarian cancer cisplatin-resistance cells. Cell proliferation was evaluated by cell counting kit-8 and colony formation assays. Cell apoptosis was assessed using Annexin V and PI staining. The relationships between SP1, MCF2L-AS1 and insulin-like growth factor-2 mRNA binding protein 1 (IGF2BP1) were verified by RNA pull-down, RIP, ChIP and dual- luciferase reporter gene assay, respectively. Tumor xenograft experiment was employed to evaluate the effects of MCF2L-AS1 silencing on ovarian cancer cisplatin-resistance in vivo. TUNEL staining and immunohistochemistry were performed in tumor tissue. Results: MCF2L-AS1 and IGF2BP1 were upregulated in cisplatin-resistant cells. MCF2L-AS1 silencing suppressed cell proliferation of cisplatin-resistant cells, while promoted the apoptosis, suggesting that MCF2L-AS1 knockdown suppressed ovarian cancer cells cisplatin-resistance. Meanwhile, MCF2L-AS1 silencing enhanced cisplatin sensitivity in ovarian cancer parental cells and IGF2BP1 overexpression impaired cisplatin sensitivity of parental cells. MCF2L-AS1 activated IGF2/ MEK/ERK pathway through interacting with IGF2BP1. Transcription factor SP1 activated MCF2L- AS1 expression. MCF2L-AS1 knockdown inhibited ovarian cancer cisplatin-resistance in vivo. Conclusion: SP1-induced MCF2L-AS1 promoted ovarian cancer cisplatin-resistance through activation of IGF2/MEK/ERK pathway via interacting with IGF2BP1.
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