응급실로 내원한 급성 호중구 감소성 소장 결장염(Typhlitis) 1례

김향숙,정윤석,조준필 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Typhlitis or neutropenic enterocolitis is a life-threatening, necrotizing process of the cecum whose incidence is increasing. Typhlitis presents as fever, abdominal pain, and diarrhea in neutropenic patients. As the incidence of typhlitis increases, emergency physicians must be aware of this rapidly progressive and potentially fatal disease. The definitive management of typhlitis is controversial. The most prudent course for the emergency physician is to initiate aggressive medical management early in the ED. We describe a 25-year-old man with severe neutropenia presented to the emergency department with fever, abdominal pain, diarrhea that began 2days earlier. Abdominal computerized tomography(CT) demonstrated diffuse concentric thickening of the cecal wall, intramural edema, inflammatory bowel changes but no free air and abscess formation. He was recovered by early diagnosis and aggressive medical therapy. We report a case of typhlitis with literature reviews.

신생아 이송에서의 저체온증

김향숙,정윤석,조준필,박문성,배기수 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Back Ground : Hypothermia is a condition that can lead to serious complications and even to death in newborn. Although the temperature control is essential in neonatal care, it is often neglected during urgent transfer from local private hospitals. The purpose of this study is to evaluate the incidence and clinical outcomes of transfer induced neonatal hypothermia. Subjects and Method : In this retrospective study, subject is limited to transferred outborn babies with age less than 27 hours from June 1996 to May 1999. A total of 3,086 patients were admitted in NICU during the study period and inborn and outborn babies were 1,743(56%) and 1,343(44%) respectively. Among the 1,343 outborn babies, 212 babies were transferred from the private hospital within 24 hours of birth and were eligible for the study. Rectal temperature on arrival, transfer time, birth weight, gestational age, initial arterial gas study, and clinical outcome were compared. Statistical analysis has been done with chi-sqaure test and multiple logistic regression analysis. Results : There were 84 cases(39.6%) hypothermia(<36℃) among the 212 babies and the rate of hypothermia in transfered babies have not decreased over the study period. There were significantly more hypothermia in lower gestational age (less than 28 weeks) and lower birth weight (less than 2,000gm) caused hypothermia significantly more than normal gestational age or normal range of birth weight. And time interval (less than 12 hour) from birth to arrival at emergency department was also significant factor in hypothermia. The mortality rate was three fold higher in hypothermia than normothermic or hyperthermic babies. Conclusion: This study shows that hypothermia during neonate transportation is a major cause of neonatal mortality and morbidity in prehopital care. Body temperature control during transport of neonates under 24 hours of age should be emphasized for the better outcome of treatment.

Autophagy in microglia degrades extracellular 관-amyloid fibrils and regulates the NLRP3 inflammasome.

Cho, Mi-Hyang,Cho, Kwangmin,Kang, Hoe-Jin,Jeon, Eun-Young,Kim, Hun-Sik,Kwon, Hyung-Joon,Kim, Hong-Mi,Kim, Dong-Hou,Yoon, Seung-Yong Landes Bioscience 2014 AUTOPHAGY Vol.10 No.10

<P>Accumulation of 관-amyloid (A관) and resultant inflammation are critical pathological features of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades extracellular A관 fibrils via the lysosomal system. Autophagy is a catabolic process that degrades native cellular components, however, the role of autophagy in A관 degradation by microglia and its effects on AD are unknown. Here we demonstrate a novel role for autophagy in the clearance of extracellular A관 fibrils by microglia and in the regulation of the A관-induced NLRP3 (NLR family, pyrin domain containing 3) inflammasome using microglia specific atg7 knockout mice and cell cultures. We found in microglial cultures that A관 interacts with MAP1LC3B-II via OPTN/optineurin and is degraded by an autophagic process mediated by the PRKAA1 pathway. We anticipate that enhancing microglial autophagy may be a promising new therapeutic strategy for AD.</P>

A case of keratosis punctata palmaris et plantaris(KPPP)

( Yoon Hyang Cho ),( Chee Won Oh ),( Ki Beom Park ) 대한피부과학회 1994 대한피부과학회 학술발표대회집 Vol.46 No.1

Case Reports : A Case of Atrophoderma Vermiculata with an Unusual Location

( Yoon Hyang Cho ),( Chee Won Oh ),( Tae Heung Kim ) 대한피부과학회 1995 Annals of Dermatology Vol.7 No.4

Effects of early clinical and basic laboratory exposure program on premedical students: a questionnaire survey

Cho, Kyu Hyang,Ko, Hyun Sook,Lee, Kyung Hee,Hwang, Tae-Yoon,Lee, Keun-Mi,Kim, Sae Yoon,Chang, Min Cheol Yeungnam University College of Medicine 2022 Yeungnam University Journal of Medicine Vol.39 No.4

Background: Because premed students do not take courses related to medicine during their first 2 years, they cannot establish their identity as students at medical schools, making it difficult for them to set goals as future doctors. We conducted an early clinical and basic laboratory exposure program for premed students and studied the effects of the program and student satisfaction levels. Methods: We performed an early clinical and basic laboratory exposure program for premed students for 2 days and evaluated the effects of the program and student satisfaction with it. The program consisted of two types: type 1, where two to four students formed a group, which was assigned to a particular department to participate and make observations during ward rounds, outpatient clinics, examinations, procedures, and surgeries (in the case of basic laboratory work, the students partook in experimental observations); and type 2, where one student followed a medical school professor to observe the professor's day. After the program ended, an online survey was conducted to investigate the effects on students, their thoughts, and satisfaction levels. Results: In total, 114 students (91.2%) responded to the survey. Approximately 94% of them were satisfied with the program. They found that the program would be useful for deciding on future career paths, gaining knowledge about a department of interest, studying for a medical program after premedical studies, and befriending residents and professors in certain departments. Conclusion: Early clinical and basic laboratory exposure programs are recommended for premedical students.

수종 Quinolone계 항생제의 광독성 평가

조윤향 ( Yoon Hyang Cho ),김태흥 ( Tae Heung Kim ),박흥배 ( Heung Bae Park ),박철근 ( Chul Kun Park ),박기민 ( Kee Min Park ) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.6

Background : The photsensitizing effect of quinolones has been recognized since their introdulation as an antibacterial agents. Recently several new second eneration antibacterial agents of this pharmacological class have become available for therapy, and are gaining increasing impotance, Objective : To reveal the phototoxic potentials of some new quinolones by photohemolysis test, estimation of fluorescenc spectra, and Candida albicans test. Methods : Nalidixic acid and four second-generation quinolones(ciprofloxacin, enoxacini, norfloxacin, and ofloxacitid were examined by fluorescence spertra which measured t.he phototoxc potentials by photochemial instability, photohemolsis test for the phototoxic properties against cell membranes and Candida tlbicans test for phototoxic properties against DNA. Results : All drugs showed a fluorescence spectra within 360 nm to 450 nm, and in the photohemolysis test, all studied drug except ofloxacin got above 5% hemolytic value, and all drugs showed clear zone. in Candida albicans test after 48hours. Conclusion : These results suggested that all tested drugs were photochemically unstable. According to the mechanisris of cellular phototoxicity, ciprofloxacin, enoxacin, and norfloxacin was phtototoxic to nucleus and cell membrane, whereas ofloxacin was phototoxic to nucleus only. (Kor J Dermatol 1995;33(6): 1021-1028)

Marjolin ` s ulcer 2예

조윤향(Yoon Hyang Cho),김태흥(Tae Heug Kim),박기범(Ki Beom Park) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5

Marjolins ulcer is a special type of skin malignancy arising from previous scar site. We report two cases of Marjolins ulcer arising from chronic deg enerating burn scar. A 65-year-old male had a 9 x 15cm sized ulcer on his right popliteal fossa. He had a history of burn when he was seventeen years old and an ulcerati 1g tumor developed at the site of burn scar about 1 year ago. The ulcer became progressively penlarged in size and also painful. Skin biopsy revealed squamous cell carcinoma and,subsequently Above-Knee amputation was done. Another 54-year-old male had a painful coin sized ulcer on his right popliteal fossa where he had burn at the age of thirty-four. The ulcer was developed at the site of burn scar about 2months ago. The pathologic diagnosis was squamous cell carcinoma. He was recommended to get his leg amputated, but it was refused. (Kor J Dermatol 1902;30(5):737-742)

Trichorhinophalangeal 증후군

조윤향(Yoon Hyang Cho),김태흥(Tae Heung Kim),박기범(Ki Beom Park),송해룡(Hae Ryong Song) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

Trichorhinophalangeal syndiome, a rare genetic disease, is characterzed by the triad of slow growing, brittle hair with early loss, a pear-shaped nose with bulbous tip and long philtrum, and coneshaped phalangeal epiphyses wiith resultant shortening and. deformity of hands and feet. A 24-year-old female visited our department for the evaluation of lalopecia. She had had sparse, thin, and brittle hair since birth. She also complained of short fingers ar d a pear-shaped nose with bulbous tip. The X-ray findings of her hands and feet showed cone-shaped epiphyses with shortening of the phalangeal bones. There was no family history of hair, nasal, or palnkoplantar phalangeal abnormality. Chromosomal study did not reveel any abnormal finding. Shortened phalangeal bones of her index and middle fingers were slightly improved by lengthening procedure with iIlizarov apparatus. (Kor J Dermatol 1994;32(5):920-925)

유아교육기관의 창의적 역량, 유아발달, 유아교사의 공감능력과의 관계

채승희(Chae Seung Hee),김정희(Kim Jung Hee) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.19

본 연구의 목적은 유아교육기관의 창의적 역량, 유아발달, 유아교사의 공감능력과의 관계를 알아보기 위함이다. 이를 위하여 서울·경기지역 유아교육기관 교사 550명을 대상으로 설문조사를 실시하였고, 이메일, 우편, SNS를 통해 회수된 설문지는 최종 507부였다. 설문자료 분석은 SPSS 25.0을 사용해 분석했다. 연구결과는 첫째, 유아교육기관의 창의적 역량, 유아발달, 유아교사의 공감능력의 일반적 경향성에 대해 알아본 결과 모두 다소 높은 것으로 나타났다. 둘째, 유아교육기관의 창의적 역량의 하위변인과 유아발달의 하위변인과의 상관관계는 모두 정적 상관관계로 나타났다. 또한 유아발달의 하위변인과 유아교사의 공감능력의 하위변인과의 상관관계 역시 모두 정적 상관관계로 나타났다. 셋째, 유아교육기관의 창의적 역량이 유아교사의 공감능력에 유의미한 영향을 미치고, 유아교육기관의 창의적 역량이 유아의 발달에 유의미한 영향을 미쳤다. 또한 유아교사의 공감능력은 유아교육기관의 창의적 역량과 유아발달과의 관계에서 부분매개효과를 가지는 것으로 나타났다. 따라서 유아교육기관에서 유아교사가 공감능력을 향상시키고, 다양한 창의적 역량을 키울 수 있는 환경 및 교육을 제공한다면 유아교육기관의 교육적 질을 높여 유아들의 전인적인 발달에 기여할 수 있을 것으로 사료된다. The purpose of this study is to investigate the relationship between the creative capacity of early childhood education institutions, early childhood development, and the empathy ability of early childhood teachers. For this, a questionnaire survey was conducted targeting 550 teachers of early childhood education institutions in Seoul and Gyeonggi Province, and the final survey was 507 copies. The survey data were analyzed using SPSS 25.0. The results of the study: First, the creative capacity of early childhood education institutions, early childhood development, and the empathy ability of early childhood teachers, all were found to be somewhat high. Second, the correlations between the creative capacity of early childhood education institutions and early childhood development were all positively correlated. In addition, the correlation between early childhood development and the empathy ability of early childhood teachers was also positively correlated. Third, the creative capacity of early childhood education institutions had an effect on the empathy ability of early childhood teachers, and the creative capacity of early childhood education institutions had an effect on early childhood development. In addition, it was found that the empathy ability of early childhood teachers has a partial mediating effect in the relationship between the creative capacity of early childhood education institutions and early childhood development. Therefore, it is thought that if early childhood teachers improve empathy and provide environment and education to develop various creative capacity, early childhood education institutions can enhance the educational quality and contribute to the holistic development of children.