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Yang Yang,Huang Shan,Wang Jun,Nie Xiao,Huang Ling,Li Tianfa 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.1
Wogonin, extracted from the roots of Scutellaria baicalensis Georgi, has been shown to suppress collagen deposition in spontaneously hypertensive rats (SHRs). This study was performed to investigate the role and mechanism of wogonin underlying vascular remodeling in SHRs. After injection of SHRs with 40 mg/kg of wogonin, blood pressure in rats was measured once a week. Masson's trichrome staining was conducted to observe the changes in aortas and mesenteric arteries. Vascular smooth muscle cells (VSMCs) isolated from rat thoracic aortas were treated with Angiotensin II (Ang II; 100 nM) in the presence or absence of varying concentrations of wogonin. The viability and proliferation of VSMCs were examined using Cell Counting Kit-8 assay and 5-ethynyl-2’-deoxyuridine assay, respectively. The migration of VSMCs was examined using wound healing assay and transwell assay. We found that wogonin administration alleviated hypertension, increased lumen diameter, and reduced the thickness of the arterial media in SHRs. Ang II treatment enhanced the viability of VSMCs, which was inhibited by wogonin in a concentration -dependent manner. Wogonin reversed Ang II-induced increases in the viability, proliferation, and migration of VSMCs. Moreover, wogonin inhibited Ang II-induced activation of mitogen-activated protein kinase (MAPK) signaling in VSMCs. Overall, wogonin repressed the proliferative and migratory capacity of VSMCs by regulating the MAPK signaling pathway, thereby attenuating vascular remodeling in hypertensive rats, indicating that wogonin might be a therapeutic agent for the treatment of vascular diseases.
Yang Nie,Lili Jing,Pengyu Zhao 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.12
In this paper, two Cortex-A9 processors and microblaze processor are used to build a multiprocessor embedded system. The whole system is connected AXI Interconnect, and the shared memory is used as a communication mechanism. Embedded multiprocessor system is mapped into FPGA, and the feasibility and practicability of the system are verified. Simulation result Indicate that shared memory provides very high performance and low latency access from both processors compared with the DDR memory.
A Interlaced Filling Algorithm in Deterministic Constructing Compressed Sensing Matrix
Yang Nie,Xin-Le Yu,Zhan-Xin Yang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.10
The sensing matrix has an important influence on the original signal sampling and reconstruction algorithm in the compressed sensing theory. A complete random sensing matrix has the drawbacks of large storage and high complexity in its implementation. In this paper, we propose an interlaced filling algorithm to construct the sensing matrix, which has a quasi-cyclic structure for efficient hardware implementation. The new sensing matrix has small coherence, which provides assurance for the recovery of sparse signal. Meanwhile, some experimental comparison with the other sensing matrix is accomplished. The simulation results demonstrate that the proposed sensing matrix not only obtains better performance but also owns easy hardware implementation.
Deterministic Construction of Compressed Sensing Matrix Based on Q-Matrix
Yang Nie,Xin-Le Yu,Zhan-Xin Yang 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10
Compressed sensing is an innovative technology, which provides a new sampling mode. The key problem in compressed sensing is the construction of sensing matrix, which has an important influence on the signal sampling and reconstruction algorithm. At present, in most cases the sensing matrix is a random structure, and is difficult to realize due to its huge storage in practical applications. In this paper, we introduce a novel deterministic construction of sensing matrix via Q-matrix, which is calculated by solving the N-queens problem. The proposed sensing matrix has good orthogonality and circularity. Using the circularity of Q-matrix, we can construct sensing matrix for compressed sensing. A large number of simulation results show that the proposed sensing matrix in this paper can obtain a better quality of the reconstructed image, and it is easily realized owing to its cyclic characteristic.
Model-Based Design Methodology for Sampling Rate Converter
Nie Yang,Ge Hua,Jing Li-li 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.5
The design of high-speed sampling rate converter in multi-rate system is a very complicated problem. The traditional development flow is not simply low efficiency, and but also is difficult to implementation. This paper presents a development flow by model-based design to simplify the design process, to improve work efficiency. Sampling rate converter is designed by a hybrid scheme using polyphase filter and Farrow filter structure. Through the development flow of model-based design, circuit modeling is very easy to do, and the RTL code and test code are automatically generated. The simulation results show that this method can greatly reduce the system consumption and promote the performance of the system.
Research on Embedded Network Real-Time Video Monitoring System Based on Zynq
Yang Nie,Xiaofei Yin,Yu Hu,Hanbin Xu,Ruofei Yan 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.11
With the improvement of the performance of the embedded processor, the real-time network video monitoring system based on embedded technology becomes a developing direction of the network video with its low price and portability. In this paper, software and hardware co-design method is adopted to design an embedded system. ARM of the Zynq chip is responsible for embedded system structures and high definition video processing, and FPGA is used to design other logic and hardware expansion. Compared with the traditional network video monitoring technology, the embedded network video monitoring technology based on Zynq not only improves the quality of the image, but also has better real-time performance and scalability.
Effects of gas signaling molecule SO2 in cardiac functions of hyperthyroid rats
Yang Qi,Yang Ting,Liu Xing,Liu Shengquan,Liu Wei,Nie Liangui,Chu Chun,Yang Jun 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.2
Sulfur dioxide (SO2), a novel endogenous gas signaling molecule, is involved in the regulation of cardiac function. Exerting a key role in progression of hyperthyroidism-induced cardiomyopathy (HTC), myocardial fibrosis is mainly caused by myocardial apoptosis, leading to poor treatment outcomes and prognoses. This study aimed to investigate the effect of SO2 on the hyperthyroidism-induced myocardial fibrosis and the underlying regulatory mechanisms. Elisa, Masson staining, Western-Blot, transmission electron microscope, and immunofluorescence were employed to evaluate the myocardial interstitial collagen deposition, endoplasmic reticulum stress (ERS), apoptosis, changes in endogenous SO2, and Hippo pathways from in vitro and in vivo experiments. The study results indicated that the hyperthyroidism-induced myocardial fibrosis was accompanied by decreased cardiac function, and down-regulated ERS, apoptosis, and endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2 in cardiac myocytes. In contrast, exogenous SO2 donors improved cardiac function, reduced myocardial interstitial collagen deposition, up-regulated AAT1/2, antagonized ERS and apoptosis, and inhibited excessive activation of Hippo pathway in hyperthyroid rats. In conclusion, the results herein suggested that SO2 inhibited the overactivation of the Hippo pathway, antagonized ERS and apoptosis, and alleviated myocardial fibrosis in hyperthyroid rats. Therefore, this study was expected to identify intervention targets and new strategies for prevention and treatment of HTC.
Model-Based Design Methodology for Digital Up and Down Conversion of Software Defined Radio
Nie Yang,Ge Hua,Jing Li-li,Zhao Peng-yu 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.4
This paper proposes an efficient implementation of digital up and down conversion for Software Defined Radio (SDR) using Model-Based Design (MBD). In particular, a novel flow for designing digital up and down conversion is detailed. Using MBD, a system model is at the center of the development process, from requirement development, through design, implementation, and testing. Using MBD, code can be automatically generated for system and create test benches for system verification, which is saving time and avoiding the introduction of manually coded errors. Design example shows that the proposed method can greatly reduce the complexity of digital up and down conversion while providing the efficient and reliability of design flow.
Measurement Matrix Construction Algorithm for Compressed Sensing based on QC-LDPC Matrix
NIE Yang,JING Li-li 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.2
The measurement matrix of compressed sensing has a significant impact for sampling and reconstruction algorithm of the original signal. At present, the majority of the measurement matrix is randomly constructed, and it is difficulty for hardware implementation in the practical applications. In this paper, we use the sparse characteristic of parity- check matrix of LDPC codes, construct measurement matrix based on QC-LDPC (Quasi-cyclic low-density parity-check) matrix, which is a structural and sparse deterministic measurement matrix. The simulation results show that, the measurement matrix is proposed in this paper not only can obtain a better reconstructed image quality, but also it can reduce the complexity of hardware implementation for quasi-cyclic.