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Xian Wang,Suping Fang,Xindong Zhu,Jing Ji,Pengcheng Yang,Masaharu Komori,Aizoh Kubo 한국광학회 2017 Current Optics and Photonics Vol.1 No.6
The extraction of the valid measurement region from the interference fringe pattern is a significant stepwhen measuring gear tooth flank form deviation with grazing incidence interferometry, which will affectthe measurement accuracy. In order to overcome the drawback of the conventionally used method in whichthe object image pattern must be captured, an improved segmentation approach is proposed in this paper. The interference fringe patterns feature, which is smoothed by the nonlinear diffusion, would be extractedby the structure tensor first. And then they are incorporated into the vector-valued Chan-Vese model toextract the valid measurement region. This method is verified in a variety of interference fringe patterns,and the segmentation results show its feasibility and accuracy.
Zhu, Hong-Lin,Wei, Xing,Qu, Shun-Lin,Zhang, Chi,Zuo, Xiao-Xia,Feng, Yan-Sheng,Luo, Qi,Chen, Guang-Wen,Liu, Mei-Dong,Jiang, Lei,Xiao, Xian-Zhong,Wang, Kang-Kai Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.8
Cardiomyocytes can resist ischemia/reperfusion(I/R) injury through ischemic postconditioning (IPoC) which is repetitive ischemia induced during the onset of reperfusion. Myocardial ischemic preconditioning up-regulated protein 2 (MIP2) is a member of the WD-40 family proteins, we previously showed that MIP2 was up-regulated during ischemic preconditioning (IPC). As IPC and IPoC engaged similar molecular mechanisms in cardioprotection, this study aimed to elucidate whether MIP2 was up-regulated during IPoC and contributed to IPoC-mediated protection against I/R injury. The experiment was conducted on two models, an $in$ $vivo$ open chest rat coronary artery occlusion model and an $in$ $vitro$ model with H9c2 myogenic cells. In both models, 3 groups were constituted and randomly designated as the sham, I/R and IPoC/hypoxia postconditioning (HPoC) groups. In the IPoC group, after 45 min of ischemia, hearts were allowed three cycles of reperfusion/ischemia phases (each of 30 s duration) followed by reperfusion. In the HPoC group, after 6 h of hypoxia, H9c2 cells were subjected to three cycles of 10 minute reoxygenation and 10 minute hypoxia followed by reoxygenation. IPoC significantly reduced the infarct size, plasma level of Lactate dehydrogenase and creatine kinase MB in rats. 12 h after the reperfusion, MIP2 mRNA levels in the IPoC group were 10 folds that of the sham group and 1.4 folds that of the I/R group. Increased expression of MIP2 mRNA and attenuation of apoptosis were similarly observed in the HPoC group in the $in$ $vitro$ model. These effects were blunted by transfection with MIP2 siRNA in the H9c2 cells. This study demonstrated that IPoC induced protection was associated with increased expression of MIP2. Both MIP2 overexpression and MIP2 suppression can influence the IPoC induced protection.
Three new diphenylpropanes from Celastrus hindsii
Xian Qing Hu,Wei Han,Zhu Zhen Han,Qing Xin Liu,Xi-Ke Xu,Peng Fu,Hui-Liang Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.11
Three new diphenylpropanes, HindsiipropaneA–C (1–3), together with one known arylpropyl quinoneGriffithane D (4), were isolated from Celastrus hindsii. Their structures were established by 1D and 2D nuclearmagnetic resonance spectroscopic analysis, and massspectroscopy. Compound 4 was firstly obtained in thisgenus. All the isolated compounds were evaluated in vitrofor cytotoxicity against four human tumor cell lines (A549,HCT116, MDA-MB-231, BEL7404) by the MTT assay.
Zhu, Cheng-Lin,Huang, Qiang,Liu, Chen-Hai,Lin, Xian-Sheng,Xie, Fang,Shao, Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphisms have been reported to influence the risk for digestive tract cancer (DTC) in many studies; however, the results remain controversial and ambiguous. We therefore carried out a meta-analysis of published case-control studies to derive a more precise estimation of any associations. Electronic searches were conducted on links between this variant and DTC in several databases through April 2012. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of associations in fixed or random effect models. Heterogeneity and publication bias were also assessed. A total of 21 case-control studies were identified, including 6,198 cases and 7,583 controls. Overall, there was a statistically significant association between the NQO1 C609T polymorphism and DTC risk (TT vs. CC: OR=1.224, 95%CI=1.055-1.421; TT/CT vs. CC: OR=1.195, 95%CI=1.073-1.330; TT vs. CT/CC: OR=1.183, 95%CI=1.029-1.359; T vs. C: OR=1.180, 95%CI=1.080-1.290). When stratified for tumor location, the results based on all studies showed the variant allele 609T might have a significantly increased risk of upper digest tract cancer (UGIC), but not colorectal cancer. In the subgroup analysis by ethnicity, we observed a significantly risk for DTC in Caucasians. For esophageal and gastric cancer, a significantly risk was found in both populations, and for colorectal, a weak risk was observed in Caucasians, but not Asians. This meta-analysis suggested that the NQO1 C609T polymorphism may increase the risk of DTC, especially in the upper gastric tract.
Zhu, Zhao-Yong,Shi, Qing-Ming,Han, Bao-Feng,Wang, Xian-Feng,Qiang, Sheng,Yang, Chun-Long Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.9
Twenty novel tetramic acid derivatives (E)-3-(1-(alkyloxyamino)ethylidene)-1-alkylpyrrolidine-2,4-diones were synthesized by the reaction of 3-(1-hydroxyethylidene)pyrrolidine-2,4-diones with O-alkyl hydroxylamines. The title compounds were confirmed by IR, $^1H$ NMR, MS and elemental analysis. The structure of compound 6r was further verified by X-ray diffraction crystallography. The bioassays showed that most of the title compounds exhibited noticeable herbicidal and fungicidal activities.
생장단계별 배 과육에서 추출된 펙틴의 이화학 특성 및 포도당 흡수 저해 효과
장선(Xian Zhang),이범수(Fan-Zhu Lee),은종방(Jong-Bang Eun) 한국식품과학회 2008 한국식품과학회지 Vol.40 No.5
상품성이 낮은 배의 부가가치 증대와 배 펙틴의 산업적 이용을 위한 목적으로 생장시기에 따라 배 과육에서 펙틴을 추출하여 그 특성을 조사하였다. 산처리법에 의한 펙틴의 추출수율은 배 과실이 성숙됨에 따라 감소하였고 유과로부터 추출한 펙틴의 L<SUP>*</SUP>값은 미숙과나 성숙과에서 추출한 펙틴의 L<SUP>*</SUP>값에 비하여 낮았고 a<SUP>*</SUP>값과 b<SUP>*</SUP>값은 더 높았다. 순도는 22.77-43.07%로 비교적 낮았고 메톡실함량은 3.44-6.73%, DE값은 21.08-41.25%로 저메톡실펙틴이었으며 품종내 성숙과에서 추출한 펙틴의 메톡실함량이 가장 높았다. 고유점도는 1.90-3.81 dL/g이었고 포도당 흡수 지연효과는 약 30% 혹은 그 이상으로 비교적 높은 효과를 보였다. 메톡실함량과 DE값은 고유점도와 5% 수준에서, 포도당 흡수 지연 효과와는 1% 수준에서 높은 상관을 보였고 고유점도는 포도당 흡수 지연효과에 영향을 미치는 것으로 나타났다. 결론적으로 배과육에서 산처리법으로 추출한 펙틴은 저칼로리 식품 생산에 그리고 기능성 식품 개발에서 좋은 수용성 식이섬유로 이용 가능할 것으로 생각되며 펙틴 추출 시 순도를 높이기 위한 연구가 더 어루어져야 할 것으로 생각된다. Properties of pectin extracted from flesh of Asian pear in 3 cultivars were investigated at different growth stages. The extraction yields of pectin by the acidic treatment decreased during the growth. The L<SUP>*</SUP> value of young fruit was lower than unripe and ripe fruit, and a<SUP>*</SUP> and b<SUP>*</SUP> value were higher in the same cultivars. The degree of esterification (DE) and intrinsic viscosity of pectin were 21.1-41.3% and 1.90-3.81 dL/g, respectively. The pectin extracted from flesh of pear showed about 30% glucose retarding effect. The DE value had a high correlation with retarding effect on glucose transport and intrinsic viscosity (p<0.01 and p<0.05). The intrinsic viscosity of the pectin seems to affect the retardation of glucose transport in blood. Pectin extracted from flesh of Asian pear by acidic treatment could be a good source to develop low calorie and functional food.