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RISS 인기검색어
- 검색키워드
- 저자 : Weizhe Jiang (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Study of creep-fatigue behavior in a 1000 MW rotor using a phenomenological lifetime model
Nai-long Zhao,Weizhe Wang,Jishen Jiang,Ying Zheng Liu 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2
In this study, the phenomenological lifetime model was applied to part of an ultra-supercritical steam turbine rotor model to predict its lifetime as a post processing of the finite element method. To validate the accuracy and adaptation of the post processing program, stressstrain hysteresis loops of a cylinderal model under service-like load cycle conditions in cycle N = 1 and 300 were constructed, and the comparison of the results with experimental data on the same cylinderal specimen showed them to be satisfactory. The temperature and von Mises stress distributions of the rotor during a startup-running-shutdown-natural cool process were numerically studied using ABAQUS and the damage caused by the interaction of creep and fatigue was subsequently computed and discussed. It was found that the maximum damage appeared at the inlet notch zone, with the blade groove areas and the front notch areas also suffering a large damage amplitude.
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Cao, Wen,Mo, Kai,Wei, Sijun,Lan, Xiaobu,Zhang, Wenjuan,Jiang, Weizhe The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22-xenograft models by inhibiting the inflammatory cytokines and $NF-{\kappa}B$ p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given to H22 tumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of $CD4^+/CD8^+$ and the secretion of interleukin (IL)-2 and interferon-${\gamma}$, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2. The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.
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Wen Cao,Kai Mo,Sijun Wei,Xiaobu Lan,Wenjuan Zhang,Weizhe Jiang 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22-xenograft models by inhibiting the inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given to H22 tumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4+/CD8+ and the secretion of interleukin (IL)-2 and interferon-γ, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2 . The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.
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