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Kyoungjin Kang,Sun Woo Lee,Phoebe Kar Wai Lam 대한미용의학회 2020 대한미용의학회지 Vol.4 No.2
Thread-lifting is a minimally invasive face-lifting procedure that lifts and reposition ptotic soft tissue associated with ageing. This procedure has become increasingly more popular in the last decade. mid-face widening (MFW) is a frequent complaint after thread-lifting, as the descended ptotic soft tissues gathered to the middle of the thread during repositioning. The bunching up of the lax soft tissue increases both the facial volume and the MFW. We attempt to overcome the MFW as an unexpected common complication. Three patients underwent our thread-lifting procedure and followed up for six months. The assessment parameter, bizygomatic diameter (BZD), taken at baseline, three and six-month follow-up with standardised digital computerised 3-dimensional (3D) images using MIRAGE 3D, Taiwan. The floating 90 mm and 115 mm threads, were inserted in the following sequence: first, two single-layers (temporal and high temporal, along the superior temporal line) and then, one dual-layer (zygomatic/cheek region). This thread arrangement aims to overcome and correct the position-dependent downward sagging and volume loss associated with facial ageing, but without increasing the MFW of the patients. None of the patients developed MFW following thread-lifting at three- and six months following treatment. An observed reduction between 4.7-17.9 mm (average, 11.3 mm) in BZD recorded at six-month follow-up. There was no significant discomfort or complications have been reported. Based on the results of our cases, this floating technique, combining two single and one dual-layer, in the three regions (temporal, high temporal and zygomatic/cheek) appears favourable in achieving satisfactory face-lifting and rebalancing facial volume without an increase in MFW.
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Insights from a Prospective Follow-up of Thyroid Function and Autoimmunity among COVID-19 Survivors
David Tak Wai Lui,Chi-Ho Lee,Wing-Sun Chow,Alan Chun Hong Lee,Anthony Raymond Tam,Carol Ho Yi Fong,Chun Yiu Law,Eunice Ka Hong Leung,Kelvin Kai Wang To,Kathryn Choon Beng Tan,Yu-Cho Woo,Ching Wan Lam 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.3
Background: The occurrence of Graves’ disease and Hashimoto thyroiditis after coronavirus disease 2019 (COVID-19) raised concerns that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger thyroid autoimmunity. We aimed to address the current uncertainties regarding incident thyroid dysfunction and autoimmunity among COVID-19 survivors. Methods: We included consecutive adult COVID-19 patients without known thyroid disorders, who were admitted to Queen Mary Hospital from July 21 to September 21, 2020 and had serum levels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine (fT3), and anti-thyroid antibodies measured both on admission and at 3 months. Results: In total, 122 patients were included. Among 20 patients with abnormal thyroid function tests (TFTs) on admission (mostly low fT3), 15 recovered. Among 102 patients with initial normal TFTs, two had new-onset abnormalities that could represent different phases of thyroiditis. Among 104 patients whose anti-thyroid antibody titers were reassessed, we observed increases in anti-thyroid peroxidase (TPO) (P<0.001) and anti-thyroglobulin (P<0.001), but not anti-thyroid stimulating hormone receptor titers (P=0.486). Of 82 patients with negative anti-TPO findings at baseline, 16 had a significant interval increase in anti-TPO titer by >12 U, and four became anti-TPO-positive. Worse baseline clinical severity (P=0.018), elevated C-reactive protein during hospitalization (P=0.033), and higher baseline anti-TPO titer (P=0.005) were associated with a significant increase in anti-TPO titer. Conclusion: Most patients with thyroid dysfunction on admission recovered during convalescence. Abnormal TFTs suggestive of thyroiditis occurred during convalescence, but infrequently. Importantly, our novel observation of an increase in anti-thyroid antibody titers post-COVID-19 warrants further follow-up for incident thyroid dysfunction among COVID-19 survivors.
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Chi-Ho Lee,Wai-Kay Seto,Kelly Ieong,David T.W. Lui,Carol H.Y. Fong,Helen Y. Wan,Wing-Sun Chow,Yu-Cho Woo,Man-Fung Yuen,Karen SL Lam 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.1
Background: In non-alcoholic fatty liver disease (NAFLD), transient elastography (TE) is an accurate non-invasive method to identify patients at risk of advanced fibrosis (AF). We developed a diabetes-specific, non-invasive liver fibrosis score based on TE to facilitate AF risk stratification, especially for use in diabetes clinics where TE is not readily available. Methods: Seven hundred sixty-six adults with type 2 diabetes and NAFLD were recruited and randomly divided into a training set (n=534) for the development of diabetes fibrosis score (DFS), and a testing set (n=232) for internal validation. DFS identified patients with AF on TE, defined as liver stiffness (LS) ≥9.6 kPa, based on a clinical model comprising significant determinants of LS with the lowest Akaike information criteria. The performance of DFS was compared with conventional liver fibrosis scores (NFS, FIB-4, and APRI), using area under the receiver operating characteristic curve (AUROC), sensitivity, specificity, positive and negative predictive values (NPV). Results: DFS comprised body mass index, platelet, aspartate aminotransferase, high-density lipoprotein cholesterol, and albuminuria, five routine measurements in standard diabetes care. Derived low and high DFS cut-offs were 0.1 and 0.3, with 90% sensitivity and 90% specificity, respectively. Both cut-offs provided better NPVs of >90% than conventional fibrosis scores. The AUROC of DFS for AF on TE was also higher (P<0.01) than the conventional fibrosis scores, being 0.85 and 0.81 in the training and testing sets, respectively. Conclusion: Compared to conventional fibrosis scores, DFS, with a high NPV, more accurately identified diabetes patients at-risk of AF, who need further evaluation by hepatologists.
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Deformable Dictionary Learning for SAR Image Change Detection
Li, Lin,Zhao, Yongqiang,Sun, Jinjun,Stolkin, Rustam,Pan, Quan,Chan, Jonathan Cheung-Wai,Kong, Seong G.,Liu, Zhunga IEEE 2018 IEEE transactions on geoscience and remote sensing Vol.56 No.8
<P>This paper proposes a novel method based on deformable dictionary learning for detecting the regions of change between multitemporal image pairs. We build on our previous work, which constructed a pair of dictionaries. The main shortcoming of this method was its dependence on a large amount of training data. In practice, there is often a shortage of ground-truthed training images, which limits the expression capability of the resulting dictionaries. This paper overcomes this challenge by incorporating the concept of deformation, wherein each atom of a dictionary is no longer a simple image patch, but instead is a flexible image deformation function. This enables the creation of more expressive dictionaries, capable of generalizing to a far greater variety of image patterns, while using a far smaller amount of ground-truthed images for supervised dictionary training. Deformation similarity is employed for patch matching to find the best set of atoms in the difference image (DI) dictionary for reconstructing image patches for a new input DI. Each such atom can be deformed to achieve a better match, thus extending generality while reducing the number of atoms needed in the dictionary. Multiple deformed atoms are weighted and combined to best reconstruct the input DI patch. Then, the same set of deformations and weights is projected to the corresponding atoms in the CD dictionary to obtain the output change-detection map. Experiments in six realistic synthetic aperture radar data sets demonstrate the robustness and efficiency of the proposed method in comparison with five other state-of-the-art methods from the literature.</P>
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( Yong Seong Lee ),( Kyaw Wai Naning ),( Xuan Hoa Nguyen ),( Sun Bae Kim ),( Jae Hak Moon ),( Kil Yong Kim ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.11
Lysobacter capsici YS1215 isolated from soil previously showed nematicidal potential for biological control of the root-knot nematode. In this study, lactic acid, a nematicidal compound, was isolated from culture filtrate of YS1215, and its ovicidal activity was investigated. Purification and identification of lactic acid were performed by a series of column chromatographies and identified by 1H and 13C NMR spectra and GC-MS analysis. Our results showed that bacterial culture filtrate containing lactic acid significantly inhibited egg hatching. The lowest egg hatch rate (5.9%) was found at a high concentration (25 μl/ml) of lactic acid at 5 days after incubation, followed by 20 (15.2%), 15 (23.7%), 10 (29.8%), and 5 (36.4%) μl/ml, while egg hatching in the control (sterile distilled water) was 44.5%. This is the first report of lactic acid as an ovicidal compound, and it may be considered as an alternative of chemical pesticide against root-knot nematodes.
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Design of 1500V solar inverter stack beyond megawatt in NPC1 topology
Xin Hao,Kwok-Wai Ma,Jia Zhao,Xin-Yu Sun 전력전자학회 2017 전력전자학술대회 논문집 Vol.2017 No.7
This paper describes a design concept of NPC1 power stack for 1500VDC megawatt level solar inverter. This stack uses three latest half-bridge IGBT modules with highest power density and operation junction temperature, which enable realization of power level beyond 1MW without paralleling. Critical design concept on loop inductance is explained. Dynamic characteristics are verified by double-pulse test. Thermal characteristics and output power limits are verified by thermal test. Temperature-sensitive component on PCB as output power constraint is identified. Different PCB repositioning solutions are tested to give the overall output power thermal derating curves, which enable output power of 1.15MW at TA=55°C with 15°C thermal margin. The power stack characteristic and performance change under different thermal environment is further analyzed.
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( Won Young Tak ),( Vincent Wai-sun Wong ),( George Boon Bee Goh ),( Pin-nan Cheng ),( Eric J. Lawitz ),( Zobair M. Younossi ),( Raj Vuppalanchi ),( Natalie H. Bzowej ),( Ziad Younes ),( Naim Alkhouri 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Background: Routinely available noninvasive tests of fibrosis (NITs) can be used to identify patients with advanced fibrosis due to NASH, but their performance may vary by race. Our aim was to evaluate the effect of patient race on the diagnostic performance of NITs using data from the global phase 3 STELLAR studies of selonsertib. Methods: The STELLAR studies (NCT03053050 and NCT03053063) enrolled patients with bridging fibrosis (F3) or compensated cirrhosis (F4) due to NASH (NAFLD Activity Score [NAS] ≥3). Baseline liver biopsies were centrally read using the NASH Clinical Research Network classification and NITs, including the NAFLD fibrosis score (NFS), Fibrosis-4 (FIB-4) index, Enhanced Liver Fibrosis (ELF) test, and liver stiffness by transient elastography (LS by TE) were measured. The performance of these tests to discriminate advanced (F3-F4) fibrosis by self-reported patient race was evaluated using areas under the receiver operating characteristics curves (AUROCs) with 5-fold cross-validation repeated 100x. Results for White and Asian patients are presented; data for other races (5% of patients screened) are excluded. Results: Among 3202 patients screened for the STELLAR studies with evaluable liver histology, 24% were Asian and 71% were White. The median age was 58 years in both groups; 47% of Asians and 57% of Whites were female (p<0.0001). The prevalence of F3-F4 fibrosis was 67% in Asians and 72% in Whites (p=0.01). AUROCs for each of the NITS for the discrimination of advanced fibrosis were similar between Asian and White patients (Table). In general, literature-based thresholds for the NITs had similar sensitivity and specificity among the specific racial subgroups. Conclusion: In these large, global phase 3 trials, the diagnostic performance of routinely available NITs for the discrimination of advanced fibrosis due to NASH was acceptable and similar between Asian and White patients.
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