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Effectiveness and Safety of Glycoprotein IIb/IIIa Inhibitors and Clopidogrel Alone and in Combination in Non–ST-Segment Elevation Myocardial Infarction (from the National Registry of Myocardial Infarction-4)
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The Flynn effect in South Africa
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Is There a Need for Bowel Management after Surgery for Isolated Intestinal Malrotation in Children?
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소설에서 대화의 분포와 그 담화·텍스트 기능
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(처음 프로그래밍을 시작하는 입문자의 눈높이에 맞춘) 생활코딩! React 리액트 프로그래밍
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[토론문] 「현대 종교문화와 생태 공공성 : 부유하는 사적 영성을 넘어서」에 대한 토론문
- 검색키워드
- 저자 : Vrba, Jan (검색결과 5 건)
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Lukas Vrba,Bernard Walter Futscher 한국유방암학회 2017 Journal of breast cancer Vol.20 No.2
Immortality is an essential characteristic of cancer cells; a recent transcriptomic study of epithelial cell immortalization has linked epigenetic silencing of the long noncoding RNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) to this process. This study evaluated the epigenetic and transcriptional state of MORT in two premalignant conditions—ductal carcinomas in situ and colon adenomas. Results show that MORT silencing is an early epigenetic event in human carcinogenesis, likely occurring near the point where premalignant cells gain immortality; this epigenetic silencing is maintained throughout malignant transformation and metastatic growth. Additional associations between MORT loss and clinical and molecular features of breast tumors showed that silencing of MORT occurs predominantly in luminal, receptor-positive breast cancer; is associated with overexpression of CCND1 and mutations of GATA3; and is negatively correlated with TP53 mutations. Taken in toto, MORT silencing occurs early in breast carcinogenesis, probably during cellular immortalization, and precedes the development of invasive luminal breast cancer.
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New Antisense RNA Systems Targeted Against Plant Pathogens
Matousek, J.,Vrba, L.,Kuchar, M.,Pavingerova, D.,Orctova, L.,Ptacek, J.,Schubert, J.,Steger, G.,Beier, H.,Riesner, D. The Korean Society of Plant Biotechnology 2000 식물생명공학회지 Vol.27 No.5
tRNA and 7SL RNA based antisense vehicles were prepared by inserting conserved anti-viral and anti-viroid domains. Anti-PVS coat protein leader sequence (ACPL) and antistructural antihairpin domain of PSTVd (AHII) were inserted in tRNA cassette; anti- zing finger domain of PVS, AHII and anti hop latent viroid ribozyme were inserted in 7SL RNA gene isolated from A. thaliana. These constructs were shown to be transcribed both, in in vitro and in in vivo conditions. However, it followed from our work that closely linked position of PoIII reference genes and PoIIII antisense genes within T-DNA lead to the impairment of RNA expression in transgenic plants. To assay in vivo transcription of antisense genes, hairy root potato cultures were established using h. tumefaciens A4-24 bearing both, Ri plasmid and PoIII-promoterless plant expression vectors with antisense RNA genes. Expression of antisense RNA in transgenic potato tissues was proven by specific RT-PCR reactions.
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Waveguide Applicator System for Head and Neck Hyperthermia Treatment
Fiser, Ondrej,Merunka, Ilja,Vrba, Jan The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
The main purpose of this article is a complex hyperthermia applicator system design for treatment of head and neck region. The applicator system is composed of four waveguides with a stripline horn aperture and circular water bolus. The specific absorption rate (SAR) and temperature distribution from this applicator in various numerical phantom models was investigated. For used targets, the treatment planning based on the optimization process made through the SEMCAD X software is added to show the steering possibilities of SAR and thereby temperature distribution. Using treatment planning software, we proved that the SAR and temperature distribution can be effectively controlled (by amplitude and phase changing) improving the SAR and temperature target coverage approximately by 20 %. For the proposed applicator system analysis and quantitative evaluation of two parameters 25 % iso-SAR and $41^{\circ}C$ iso-temperature contours in the treatment area with the respect to sensitive structures in treatment area were defined. To verify our simulation results, the real measurement of reflectivity coefficient as well as the temperature distribution in a homogenous phantom were performed.
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Waveguide Applicator System for Head and Neck Hyperthermia Treatment
Ondrej Fiser,Ilja Merunka,Jan Vrba 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
The main purpose of this article is a complex hyperthermia applicator system design for treatment of head and neck region. The applicator system is composed of four waveguides with a stripline horn aperture and circular water bolus. The specific absorption rate (SAR) and temperature distribution from this applicator in various numerical phantom models was investigated. For used targets, the treatment planning based on the optimization process made through the SEMCAD X software is added to show the steering possibilities of SAR and thereby temperature distribution. Using treatment planning software, we proved that the SAR and temperature distribution can be effectively controlled (by amplitude and phase changing) improving the SAR and temperature target coverage approximately by 20 %. For the proposed applicator system analysis and quantitative evaluation of two parameters 25 % iso-SAR and 41°C iso-temperature contours in the treatment area with the respect to sensitive structures in treatment area were defined. To verify our simulation results, the real measurement of reflectivity coefficient as well as the temperature distribution in a homogenous phantom were performed.
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Řezáč Tomáš,Špička Petr,Zbořil Pavel,Stašek Martin,Vrba Radek,Klos Dušan 대한대장항문학회 2023 Annals of Coloproctolgy Vol.39 No.2
Purpose: Healing of colorectal anastomosis is burdened with a number of risk factors and the development of leak carries with it higher morbidity and mortality associated not only with worse quality of life but also worse oncological outcomes. The purpose of the study was an evaluation of the effect of reinforcement suture in the healing of stapler rectal anastomosis and risk factors for anastomotic leakage in mid, upper rectal and sigmoid tumors. Methods: A total of 357 patients who underwent curative resection for rectal or sigmoid tumor over 5 years were analyzed. Risk factors, baseline demographic and clinical data, and presence of leak were recorded. All statistical analyses were carried out at a significance level of P<0.05. Results: One hundred fifty-one patients met the inclusion criteria for the study. The overall incidence of leak was 2.8% in the group with reinforcement suture and 6.3% in the group without reinforcement suture. Because of the low incidence of leak the results were not statistically significant. Further results also show that none of the monitored parameters (age, weight, body mass index, tumor distance, preoperative radiotherapy, tumor stage, type of surgery) were significant predictors of anastomotic leakage. Conclusion: Although the reinforcement suture is a safe and simple option for anastomosis protection after rectal or sigmoid resections, its statistical significance was not demonstrated in our study.
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