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The epigenetic landscape of transgenerational acclimation to ocean warming
Ryu, Taewoo,Veilleux, Heather D.,Donelson, Jennifer M.,Munday, Philip L.,Ravasi, Timothy Nature Publishing Group UK 2018 Nature climate change Vol.8 No.6
<P>Epigenetic inheritance is a potential mechanism by which the environment in one generation can influence the performance of future generations(1). Rapid climate change threatens the survival of many organisms; however, recent studies show that some species can adjust to climate-related stress when both parents and their offspring experience the same environmental change(2,3). Whether such transgenerational acclimation could have an epigenetic basis is unknown. Here, by sequencing the liver genome, methylomes and transcriptomes of the coral reef fish, Acanthochromis polyacanthus, exposed to current day (+0 degrees C) or future ocean temperatures (+3 degrees C) for one generation, two generations and incrementally across generations, we identified 2,467 differentially methylated regions (DMRs) and 1,870 associated genes that respond to higher temperatures within and between generations. Of these genes, 193 were significantly correlated to the transgenerationally acclimating phenotypic trait, aerobic scope, with functions in insulin response, energy homeostasis, mitochondrial activity, oxygen consumption and angiogenesis. These genes may therefore play a key role in restoring performance across generations in fish exposed to increased temperatures associated with climate change. Our study is the first to demonstrate a possible association between DNA methylation and transgenerational acclimation to climate change in a vertebrate.</P>
Kang, Jeeun,Chang, Jin Ho,Wilson, Brian C.,Veilleux, Israel,Bai, Yanhui,DaCosta, Ralph,Kim, Kang,Ha, Seunghan,Lee, Jong Gun,Kim, Jeong Seok,Lee, Sang-Goo,Kim, Sun Mi,Lee, Hak Jong,Ahn, Young Bok,Han, American Institute of Physics 2015 Review of scientific instruments Vol.86 No.3
<P>Multi-modality imaging is beneficial for both preclinical and clinical applications as it enables complementary information from each modality to be obtained in a single procedure. In this paper, we report the design, fabrication, and testing of a novel tri-modal in vivo imaging system to exploit molecular/functional information from fluorescence (FL) and photoacoustic (PA) imaging as well as anatomical information from ultrasound (US) imaging. The same ultrasound transducer was used for both US and PA imaging, bringing the pulsed laser light into a compact probe by fiberoptic bundles. The FL subsystem is independent of the acoustic components but the front end that delivers and collects the light is physically integrated into the same probe. The tri-modal imaging system was implemented to provide each modality image in real time as well as co-registration of the images. The performance of the system was evaluated through phantom and in vivo animal experiments. The results demonstrate that combining the modalities does not significantly compromise the performance of each of the separate US, PA, and FL imaging techniques, while enabling multi-modality registration. The potential applications of this novel approach to multi-modality imaging range from preclinical research to clinical diagnosis, especially in detection/localization and surgical guidance of accessible solid tumors.</P>