Synthesis of 1,6-Disubstituted 4,5,6,7-Tetrahydropyrazolo[3,4-c]pyridin-7-one Derivatives and Evaluation of Their Anticancer Activity

Vani Nelamane Devegowda,Seon Hee Seo,배애님,Ghilsoo Nam,최경일 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.2

Promising anticancer compounds of the type 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7-ones were identified. The target compounds were readily synthesized in a large scale via a sequence of reactions starting from the commercially available primary amines. Their in vitro anti-proliferative activity has been evaluated on prostate (DU-145), colon (HT-29 and HCT-116) and melanoma (A375P) human cancer cell lines. The relationships between the structure and the anticancer activity, covering all tested cancer cell lines,revealed that the compound 5c with 2,4-dimethylphenyl substituent at R2 was the most potent with the IC50values in the range as low as 0.16 to 0.40 μM.

Backbone Network for Objects Detection with Multiple Dilation and Feature Summation

Vani Natalia Kuntjono(쿤조노 바니 나탈리아),Seung-hyun Ko(고승현),Yang Fang(방양),Geun-Sik Jo(조근식) 한국정보과학회 2017 한국정보과학회 학술발표논문집 Vol.2017 No.12

Backbone Network for Object Detection with Multiple Dilated Convolutions and Feature Summation

Vani Natalia Kuntjono(바니 나탈리아 쿤트조노),Seunghyun Ko(고승현),Yang Fang(방양),Geunsik Jo(조근식) 한국정보과학회 2018 정보과학회논문지 Vol.45 No.8

컨볼루션 뉴럴 네트워크의 발전으로 인해 객체 탐지, 이미지 세분화 및 객체 분류 분야에서도 100개 이상의 컨볼루션 레이어를 사용하는 Deep CNN을 사용하는 추세로 이어지고 있다. 그러나 Deep CNN을 사용하기 위해 많은 그래픽 메모리가 필요하며 제한된 자원이나 실시간 객체 탐지를 원하는 사람들에게는 이런 Deep CNN이 적합하지 않다. 본 논문에서는 배수 팽창된 컨볼루션과 특징합계 기반의 객체 탐지를 위한 새로운 백본 네트워크를 제안한다. 특징합계는 그래디언트를 쉽게 전달하고 컨볼빙으로 인해 발생하는 공간 정보의 손실을 최소화한다. 그리고 팽창된 컨볼루션을 사용함으로써 변수를 추가하지 않고도 개별 뉴런의 수용 영역을 넓힐 수 있다. 또한, Deep하지 않은 뉴럴 네트워크를 백본으로 사용함으로써 제한된 자원으로 이미지넷 데이터 세트에서 사전 교육을 하지 않더라도 제안하는 네트워크를 사용할 수 있다. Pascal VOC 및 MS COCO 데이터를 사용한 실험 결과 제안된 네트워크는 각각 71%와 38.2%의 정확도를 보였다. The advancement of CNN leads to the trend of using very deep convolutional neural network which contains more than 100 layers not only for object detection, but also for image segmentation and object classification. However, deep CNN requires lots of resources, and so is not suitable for people who have limited resources or real time requirements. In this paper, we propose a new backbone network for object detection with multiple dilated convolutions and feature summation. Feature summation enables easier flow of gradients and minimizes loss of spatial information that is caused by convolving. By using multiple dilated convolution, we can widen the receptive field of individual neurons without adding more parameters. Furthermore, by using a shallow neural network as a backbone network, our network can be trained and used in an environment with limited resources and without pre-training it in ImageNet dataset. Experiments demonstrate we achieved 71% and 38.2% of accuracy on Pascal VOC and MS COCO dataset, respectively.

Vascular foramina of navicular bone: a morphometric study

Vani Prathapamchandra,Praveena Ravichandran,Jayanthi Shanmugasundaram,Anbalagan Jayaraman,Rajasekar Sivaprakasam Salem 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.2

The navicular bone is supplied by more than one artery. The knowledge about the vascular foramina is important to understand the pathogenesis and management of navicular fractures. The objective of the present study is to analyze the morphology and morphometry of vascular foramina of dried human navicular bone in Indian population. The study was carried out by using 100 navicular bones (50 right and 50 left) collected from our institute and other medical institutes in and around Puducherry. The bones were macroscopically studied for vascular foramina with respect to its location, number, size, and shape. The data collected were statistically analyzed. The vascular foramina were present on dorsal, plantar, medial, and lateral surfaces of navicular bone. Kruskal-Wallis test followed by series of Mann-Whitney test for post hoc analysis showed the number of nutrient foramina observed on dorsal surface were significantly greater than those observed on the plantar (U=2,755, P=0.001), medial (U=43, P=0.001), and lateral (U=626.5, P=0.001) surfaces of the navicle. About 97.6% of foramina were circular and 2.5% were oval in appearance. About 96.7% of vascular foramina were 〈1 mm in size and 3.3% were ≥1 mm in size. Spearman’s rank correlation coefficient done showed a strong, positive correlation between vascular foramina of 〈1 mm size and circular shape, which was statistically significant (r s =0.981, P=0.001). We believe the present study has provided additional information on the vascular foramina of navicular bone and useful to surgeons in foot surgeries.

Effect of rare earth dopants on the radiation shielding properties of barium tellurite glasses

P. Vani,G. Vinitha,M.I. Sayyed,Maha M. AlShammari,N. Manikandan 한국원자력학회 2021 Nuclear Engineering and Technology Vol.53 No.12

Rare earth doped barium tellurite glasses were synthesised and explored for their radiation shieldingapplications. All the samples showed good thermal stability with values varying between 101 C and135 C based on dopants. Structural properties showed the dominance of matrix elements compared torare earth dopants in forming the bridging and non-bridging atoms in the network. Bandgap valuesvaried between 3.30 and 4.05 eV which was found to be monotonic with respective rare earth dopantsindicating their modification effect in the network. Various radiation shielding parameters like linearattenuation coefficient, mean free path and half value layer were calculated and each showed the effectof doping. For all samples, LAC values decreased with increase in energy and is attributed to photoelectricmechanism. Thulium doped glasses showed the highest value of 1.18 cm1 at 0.245 MeV for 2 mol.%doping, which decreased in the order of erbium, holmium and the base barium tellurite glass, while halfvalue layer and mean free paths showed an opposite trend with least value for 2 mol.% thulium indicating that thulium doped samples are better attenuators compared to undoped and other rare earthdoped samples. Studies indicate an increased level of thulium doping in barium tellurite glasses can leadto efficient shielding materials for high energy radiation.

Synthesis of porous Cu from Al-Cu-Co decagonal quasicrystalline alloys

Kalai Vani, V.,Kwon, O.J.,Hong, S.M.,Fleury, E. Informa UK (TaylorFrancis) 2011 Philosophical magazine Vol.91 No.19

Influence of Nanoclays and Nano-TiO2 on the Mechanical and Thermal Properties of Polycarbonate Nanocomposite

Jaya Vani. S,K Nayak,Smita Mohanty,M Rahail Parvaiz 한국고분자학회 2011 Macromolecular Research Vol.19 No.6

Polycarbonate (PC) nanocomposites were prepared using a melt intercalation technique with a series of organically modified clays and nano-TiO_2 (nTiO_2). The effect of the clay and nTiO_2 loading on the morphological,mechanical and thermal behavior of the PC nanocomposites was examined. The modulus enhancement was greater for the nanocomposite formed from PC with clay than the nTiO_2 nanocomposite. These nanocomposites also showed a significant decrease in tensile elongation and ductility with respect to nanoclays incorporation. The nTiO_2 nanocomposites also showed superior mechanical properties to the nanocomposite reinforced with nanoclay. The experimental results were compared with theoretical models. The thermal stability of PC and its nanocomposites were investigated by thermogravimetric analysis (TGA). The glass transition temperature was examined by differential scanning calorimetry (DSC). The incorporation of C30B improved the mechanical and thermal properties up to a 5wt% clay loading due to polar interactions between the PC matrix and the intercalant present in the C30B nanoclay. Wide angle X-ray diffraction (WAXD) showed an increase in the basal spacing of the C30B nanoclay confirming the presence of an intercalated structure. TEM confirmed the intercalation of a C30B clay layers and uniform dispersion of nTiO_2 particles in the PC matrix. The viscoelastic behavior examined by dynamic mechanical analysis (DMA) under a periodic stress revealed the stiffness of the PC nanocomposite in the presence of clay and n-TiO_2.

Synthesis of 1,6-Disubstituted 4,5,6,7-Tetrahydropyrazolo[3,4-c]pyridin-7-one Derivatives and Evaluation of Their Anticancer Activity

Devegowda, Vani Nelamane,Seo, Seon-Hee,Pae, Ae Nim,Nam, Ghil-Soo,Choi, Kyung-Il Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.2

Promising anticancer compounds of the type 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7-ones were identified. The target compounds were readily synthesized in a large scale via a sequence of reactions starting from the commercially available primary amines. Their in vitro anti-proliferative activity has been evaluated on prostate (DU-145), colon (HT-29 and HCT-116) and melanoma (A375P) human cancer cell lines. The relationships between the structure and the anticancer activity, covering all tested cancer cell lines, revealed that the compound 5c with 2,4-dimethylphenyl substituent at $R^2$ was the most potent with the $IC_{50}$ values in the range as low as 0.16 to $0.40{\mu}M$.

Preventive effect of Elateriospermum tapos seed extract against obese Sprague Dawley rats

Kokila Vani Perumal,Nor Liyana Ja’afar,Santhra Segaran Balan,Azrina Zainal Abidin,Daryl J. Arapoc,Nurul Husna Shafie,Hasnah Bahari 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.1

This study aimed to investigate the preventive role of Elateriospermum tapos seed extract against obese Sprague Dawley rats through assessment of bodyweight, caloric intake, organs weight, biological assays and histopathology. Thirty-six male Sprague Dawley rats were assigned into six groups of normal control (G1) group fed with standard chow diet, negative control (G2), positive control (G3) and treatment groups (G4, G5 and G6) were on high-fat and cafeteria diet for 9 weeks. G3 group was given 10 mg kg−1 of Orlistat while treatment groups were supplemented with E. tapos seed extract of 5 mg kg−1, 25 mg kg−1 and 125 mg kg−1 orally daily for another 10 weeks. Bodyweight and food intake were monitored weekly. At the end, liver, retroperitoneal white adipose tissue (rpWAT) and blood were collected for analysis of total cholesterol (TC), triglycerides (TG), low-density (LDL-C) and high density lipoprotein (HDL-C). The E. tapos seed treated groups showed significant (p < 0.05) reduction in bodyweight, caloric intake, liver and rpWAT weight as compared to the G2 group. G6 group showed tremendous improvement of liver histopathology and biological assay. There was a significant decrease (p < 0.05) of TC, TG, and LDL-C level and significant increase (p < 0.05) of HDL-C in the E. tapos seed treated group as compared to G2 group. Based on the findings, E. tapos seed extract exhibited a great potential as an anti-obesity. The extract promoted the fat oxidation by removing the uptake and storage of fat by the adipose cells and also decrease the fatty acid synthesis.

Routing System with diversion in wireless ad hoc Security

R. Divya Vani 사단법인 미래융합기술연구학회 2015 아시아태평양융합연구교류논문지 Vol.1 No.4

We consider the issue of routing packets across a multi-hop network comprising of numerous wellsprings of movement and remote connections while guaranteeing limited expected postponement. Every bundle transmission can be caught by an irregular subset of collector hubs among which the following transfer is chosen deftly. The primary test in the plan of least postponement steering strategies is adjusting the exchange off between directing the parcels along the briefest ways to the goal and circulating the activity as per the greatest backpressure. Joining critical parts of most limited way and backpressure steering, this paper gives a deliberate advancement of a disseminated pioneering directing arrangement with clog differences (D-ORCD). D-ORCD utilizes a measure of depleting time to sharply distinguish and course parcels along the ways with a normal low general clog. D-ORCD with single goal is demonstrated to guarantee a limited expected deferral for all systems and under any allowable movement, inasmuch as the rate of computations is adequately quick in respect to activity insights. Besides, this paper proposes a commonsense usage of D-ORCD which experimentally advances basic calculation parameters and their consequences for postponement and also convention overhead. Reasonable QualNet reenactments for 802.11-based systems show a critical change in the average delay over comparable solutions in the literature.