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- 저자 : Tsujiguchi, Noboru (검색결과 3 건)
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Short-Term Changes in Gut Microflora and Intestinal Epithelium in X-Ray Exposed Mice
Tsujiguchi, Takakiyo,Yamaguchi, Masaru,Yamanouchi, Kanako The Korean Association for Radiation Protection 2020 방사선방어학회지 Vol.45 No.4
Background: Gut microflora contributes to the nutritional metabolism of the host and to strengthen its immune system. However, if the intestinal barrier function of the living body is destroyed by radiation exposure, the intestinal bacteria harm the health of the host and cause sepsis. Therefore, this study aims to trace short-term radiation-induced changes in the mouse gut microflora-dominant bacterial genus, and analyze the degree of intestinal epithelial damage. Materials and Methods: Mice were irradiated with 0, 2, 4, 8 Gy X-rays, and the gut microflora and intestinal epithelial changes were analyzed 72 hours later. Five representative genera of Actinobacteria, Firmicutes, and Bacteroidetes were analyzed in fecal samples, and the intestine was pathologically analyzed by Hematoxylin-Eosin and Alcian blue staining. In addition, DNA fragmentation was evaluated by the TdT-mediated dUTP nick-end labeling (TUNEL) assay. Results and Discussion: The small intestine showed shortened villi and reduced number of goblet cells upon 8 Gy irradiation. The large intestine epithelium showed no significant morphological changes, but the number of goblet cells were reduced in a radiation dose-dependent manner. Moreover, the small intestinal epithelium of 8 Gy-irradiated mice showed significant DNA damaged, whereas the large intestine epithelium was damaged in a dose-dependent manner. Overall, the large intestine epithelium showed less recovery potential upon radiation exposure than the small intestinal epithelium. Analysis of the intestinal flora revealed fluctuations in lactic acid bacteria excretion after irradiation regardless of the morphological changes of intestinal epithelium. Altogether, it became clear that radiation exposure could cause an immediate change of their excretion. Conclusion: This study revealed changes in the intestinal epithelium and intestinal microbiota that may pave the way for the identification of novel biomarkers of radiation-induced gastrointestinal disorders and develop new therapeutic strategies to treat patients with acute radiation syndrome.
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Mechanism of ovalling vibrations of cylindrical shells in cross flow
Uematsu, Yasushi,Tsujiguchi, Noboru,Yamada, Motohiko Techno-Press 2001 Wind and Structures, An International Journal (WAS Vol.4 No.2
The mechanism of wind-induced ovalling vibrations of cylindrical shells is numerically investigated by using a vortex method. The subject of this paper is limited to a two-dimensional structure in the subcritical regime. The aerodynamic stability of the ovalling vibrations in the second to fourth circumferential modes is discussed, based on the results of a forced-vibration test. In the analysis, two modal configurations are considered; one is symmetric and the other is anti-symmetric with respect to a diameter parallel to the flow direction. The unsteady pressures acting on a vibrating cylinder are simulated and the work done by them for one cycle of a harmonic motion is computed. The effects of a splitter plate on the flow around the cylinder as well as on the aerodynamic stability of the ovalling vibrations are also discussed. The consideration on the mechanism of ovalling vibrations is verified by the results of a free-vibration test.
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FERMENTATION QUALITY EVALUATION OF ITALIAN RYEGRASS SILAGES BY USING THE BUFFER INDEX CURVE
Kim, K.H.,Tsujiguchi, J.,Uchida, S. Asian Australasian Association of Animal Productio 1992 Animal Bioscience Vol.5 No.4
This study was conducted to demonstrate the practical use of the buffer index curve as a criterion of silage quality evaluation, Forty five samples of the ensiled Italian ryegrass were collected from farms in Okayama, Japan. Silages were devided into 4 groups by the pattern of buffer index curve. Heavy wilting silages (A group) showed no peak on buffer index curve and Flieg's score of 95.6. However, moderate or weak wilting silages (B group) with moisture content of 63.3 showed a peak at pH 4.0 and a Flieg's score of 67.8. Both of A and B groups were regarded as a good quality silage. Silages (C group) with a peak at pH 4.5 were of a medium quality with Flieg's score of 45.3. Poorly preserved silages (D group) with Flieg's score of 12.0 had a peak at pH 5.0. There was a high positive correlationship (p<0.01) between the peak value of buffer index curve and the organic acid content.
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