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OK-432 Suppresses Proliferation and Metastasis by Tumor Associated Macrophages in Bladder Cancer
Tian, Yuan-Feng,Tang, Kun,Guan, Wei,Yang, Tao,Xu, Hua,Zhuang, Qian-Yuan,Ye, Zhang-Qun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
OK-432, a Streptococcus-derived anticancer immunotherapeutic agent, has been applied in clinic for many years and achieved great progress in various cancers. In the present study, we investigated its anticancer effect on bladder cancer through tumor associated macrophages (TAMs). MTS assay validated OK-432 could inhibit proliferation in both T24 and EJ bladder cell lines. OK-432 also induced apoptosis of bladder cancer cells in vitro. Consequently, we demonstrated that OK-432 could suppress the bladder cancer cells migration and invasion by altering the EMT-related factors. Furthermore, using SD rat model, we revealed that OK-432 inhibited tumor growth, suppressed PCNA expression and inhibited metastasis in vivo. Taken together, these findings strongly suggest that OK-432 inhibits cell proliferation and metastasis through inducing macrophages to secret cytokines in bladder cancer.
Yuan, Tian-Feng,Lee, Jin-Young,Min, Kyung-Hwan,Yoon, Young-Soo Hindawi Limited 2019 International journal of polymer science Vol.2019 No.-
<P>This paper presents experimental investigations on the mechanical properties of no-slump high-strength concrete (NSHSC), such as the compressive and flexural strength. First, to determine the proper NSHSC mixtures, the compressive and flexural strength of three different water-to-binder ratios (w/b) of specimens with and without polyethylene (PE) fiber was tested at test ages. Then, the effect of hybrid combinations of PE fiber and steel fiber (SF) on the compressive strength, flexural strength, flexural toughness, and flexural energy dissipation capacity was experimentally investigated. Furthermore, the various hybrid fiber-reinforced NSHSCs were evaluated, and their synergy was calculated, after deriving the benefits from each of the individual fibers to exhibit a synergetic response. The test results indicate that a w/b of 16.8% with or without fibers had lower strength and flexural strength (toughness) than those of other mixtures (w/b of 16.4% and 17.2%). Specimens with a hybrid of SF and short PE fibers exhibited a higher compressive and flexural strength, flexural toughness, energy dissipation capacity, and fiber synergy in all considered instances.</P>
Tian-Feng Yuan,Jin-Seok Choi,Seong-Kyum Kim,Young-Soo Yoon 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.3
This study investigates the influence of steel slag (SS) and steel fibers on the electrical resistivity and electromagnetic (EM) shielding effectiveness of high-strength concrete (HSC). It was found that the electrical resistivity of mixtures were mainly influenced by free water. Thus, the EM shielding effectiveness was evaluated without the effect of free water. HSC with 20% replacement ratio of SS exhibited slightly improved EM shielding, lower electrical resistivity, and reduced strength (compressive and flexural) compared to HSC without SS. However, HSC with steel fibers exhibited significantly improved EM shielding, lower electrical resistivity, and higher strength and toughness compared to HSC without steel fibers. An increase in the steel fiber content in the HSC significantly decreased the electrical resistivity and increased the shielding effectiveness, strength, and toughness. Regardless of the fiber content in the fiber volume fraction of mixture, the shielding effectiveness is similar for cases with and without SS whose electrical resistivity values differ only slightly. This proves that the EM shielding effectiveness was mainly affected by the electrical resistivity and these properties are significantly correlated when the electrical resistivity values differ noticeably. HSC reinforced with rebar with 50 mm spacing exhibited a 23.5 − 75.6% increase in the shielding effectiveness in the 600 − 1,000 MHz frequency region compared to pristine HSC.
Tian-Feng Yuan,Doo-Yeol Yoo,Jun-Mo Yang,Young-Soo Yoon 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.3
This study presents the shear capacity of eco-friendly high-strength concrete (HSC) beams reinforced by 0.75% (by volume) of hooked steel fibers or shear stirrups with various spacings. Five large-scale HSC beams with steel fibers or stirrups were tested and investigated with respect to shear capacity, failure mode, and crack patterns. The test results indicate that all five tested beams finally failed by a shear-critical failure mode and that the use of 0.75 vol% of steel fibers significantly improved the shear strength although it decreased the diagonal crack angle of HSC beam in the case of without stirrups. There are some different properties compared with ACI 318-19 recommendation, but the use of 0.75 vol% steel fibers exhibited approximately 13.2% higher shear strength when compared with that of minimum shear reinforcement for the HSC beam. Furthermore, the shear capacity of steel fibers calculated by experimental data, and it was compared with several prediction equations. The prediction models containing fiber factor were more closely agreeable with test results with a minimum of 10.9% difference.