http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
오늘 본 자료
-
유기용제 폭로가 Alzheimer질환의 위험인자로 작용하는가에 관한 환자-대조군 연구
-
堅決反擊右派分子的進攻
-
年報 : 서울大學校 醫科大學 [전자자료]
-
Medical-Dental Collaboration and Interprofessional Training for Maxillofacial Diseases at Tohoku University Hospital
-
Polysaccharides-based spray-dried microspheres for maintained stability and controlled release of protein
-
Unglück und Zerstreuung : autobiographisches Schreiben bei Franz Grillparzer
- 검색키워드
- 저자 : Tapas K. Maiti (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Immunostimulatory Properties of a Polysaccharide Isolated from Astraeus hygrometricus
Sanjaya K. Mallick,Swatilekha Maiti,Sujit K. Bhutia,Tapas K. Maiti 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
Mushrooms have been used as food and for therapeutic purpose for decades, and various compounds derived from these have potential biological activities. Application of such agents of natural origin is vital with relevance to an increase in diseases involving immune dysfunction, cancer, and autoimmune conditions in recent years. These compounds belong mainly to polysaccharides, especially β-d-glucan, glycopeptide/protein complexes, proteoglycans, proteins, and triterpenoids. Among these compounds, polysaccharides and their peptide/protein derivates have extremely important roles in immunomodulating activities. The present study aims to explore the immunomodulatory properties of polysaccharide isolated from the mushroom Astraeus hygrometricus. The polysaccharide isolated by hot alkaline extraction and chromatography was designated as AE2 and studied for its immunostimulatory potential in vivo in a murine model. Macrophages from treated mice showed higher production of nitric oxide and interleukin-1 and also exhibited an increased phagocytic potential. It also enhanced natural killer cell activation and proliferation of splenocytes with an increase in the T-helper (Th) 1 cytokine level of splenocyte culture supernatant. The cytokine level in serum also indicated a Th1 skew. The observed activities were associated with no general toxicity to the organism. The findings will be helpful in considering A. hygrometricus as a potential source of an immunomodulator and in designing further studies to understand its mode of action on immune system.
-
Bhattacharjee, Promita,Naskar, Deboki,Kim, Hae-Won,Maiti, Tapas K.,Bhattacharya, Debasis,Kundu, Subhas C. Elsevier 2015 European polymer journal Vol.71 No.-
<P><B>Abstract</B></P> <P>A comparative study of nanofibrous scaffolds with inclusion of nonmulberry silk protein fibroin is presented for application in bone tissue engineering. Introduction of silk fibroin into the scaffolds is carried out in two ways: by electrospinning blend of poly(ε-caprolactone) (PCL) and by grafting fibroin on aminolyzed electrospun nanofibrous PCL. Verification of aminolysis was provided by confocal laser microscopy of rhodamine B isothiocyanate tagged substrates. Absorbance spectroscopy of the products of the reaction between NH<SUB>2</SUB> groups and ninhydrin was used for quantification of aminolysis. Presence of nitrogen on the substrates was established using energy dispersive X-ray while scanning electron microscopy was used to substantiate their nanofibrous morphology. Evaluation of ATR-FTIR results showed that secondary structure of fibroin was preserved in the respective substrates. Presence of fibroin improves hydrophilicity, measured by dynamic contact angle, and surface roughness, topography viewed by atomic force microscopy. These characteristics support cell growth and proliferation. The mechanical strength of the scaffolds is enhanced due to presence of fibroin. Different biophysical characterizations indicate better hydrophilicity, higher nitrogen content, and higher surface roughness of the fibroin grafted scaffolds. Both fibroin-grafted and fibroin-blended scaffolds successfully support activity and viability of human osteoblast like cells. Cell cycle analysis, alkaline phosphatase assay and Alizarin red S staining are used to substantiate cell cycle pattern, proliferation and resultant neo-matrix generation on the scaffolds respectively. The results show that fibroin grafted matrices are better at supporting cell adhesion, growth, and proliferation. The findings demonstrate advantages of fibroin blended and grafted matrices for use in bone tissue engineering applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Silk fibroin from <I>Antheraea mylitta</I> was included in nanofibrous PCL matrices. </LI> <LI> Inclusion was carried out either by grafting or by blending the fibroin. </LI> <LI> Inclusion of fibroin improved strength and biocompatibility of the matrices. </LI> <LI> Fibroin grafted matrices were comparatively more biocompatible. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
