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RISS 인기검색어
- 검색키워드
- 저자 : Tandon Anshula (검색결과 4 건)
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DNA structures embedded with functionalized nanomaterials for biophysical applications
Tandon Anshula,Park Sung Ha 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.78 No.5
DNA has emerged as a useful building block for the construction of various one-, two- and three-dimensional structures. DNA structures embedded with functionalized nanomaterials are emerging for various applications, especially for biophysical applications such as drug delivery, diagnostics, biolabeling, biosensing and biodevices. This review outlines the broad spectrum of recent advances in applied DNA nanotechnology and discusses various types of DNA structures, the construction of protein-embedded DNA structures, DNA structures for drug carriers, the usage of small nucleic-acid molecules and the significance of nanoparticle-attached, carbon-based, fluorescent nanomaterial-added and ion-doped DNA structures. Finally, it provides perspectives on nanoscale structuring, emphasizes the need for sufficient production yields and up-scalable synthesis and the structural stability and future development of nanomaterial-embedded DNA structures.
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Assembly of a tile-based multilayered DNA nanostructure
Son, Junyoung,Lee, Junywe,Tandon, Anshula,Kim, Byeonghoon,Yoo, Sanghyun,Lee, Chang-Won,Park, Sung Ha The Royal Society of Chemistry 2015 Nanoscale Vol.7 No.15
<P>The Watson-Crick complementarity of DNA is exploited to construct periodically patterned nanostructures, and we herein demonstrate tile-based three dimensional (3D) multilayered DNA nanostructures that incorporate two design strategies: vertical growth and horizontal layer stacking with substrate-assisted growth. To this end, we have designed a periodically holed double-double crossover (DDX) template that can be used to examine the growth of the multilayer structures in both the vertical and horizontal directions. For vertical growth, the traditional 2D double crossover (DX) DNA lattice is seeded and grown vertically from periodic holes in the DDX template. For horizontal stacking, the DDX layers are stacked by binding the connector tiles between each layer. Although both types of multilayers exhibited successful formation, the observations with an atomic force microscope indicated that the DDX layer growth achieved with the horizontal stacking approach could be considered to be slightly better relative to the vertical growth of the DX layers in terms of uniformity, layer size, and discreteness. In particular, the newly designed DDX template layer provided a parallel arrangement between each domain with substrate-assisted growth. This kind of layer arrangement suggests a possibility of using our design scheme in the construction of other periodic structures.</P>
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Fabrication and Characterization of Finite-Size DNA 2D Ring and 3D Buckyball Structures
Jo, Soojin,Kim, Seungjae,Lee, Byung Ho,Tandon, Anshula,Kim, Byunghoon,Park, Sung Ha,Kim, Moon Ki MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.7
<P>In order to incorporate functionalization into synthesized DNA nanostructures, enhance their production yield, and utilize them in various applications, it is necessary to study their physical stabilities and dynamic characteristics. Although simulation-based analysis used for DNA nanostructures provides important clues to explain their self-assembly mechanism, structural function, and intrinsic dynamic characteristics, few studies have focused on the simulation of DNA supramolecular structures due to the structural complexity and high computational cost. Here, we demonstrated the feasibility of using normal mode analysis for relatively complex DNA structures with larger molecular weights, i.e., finite-size DNA 2D rings and 3D buckyball structures. The normal mode analysis was carried out using the mass-weighted chemical elastic network model (MWCENM) and the symmetry-constrained elastic network model (SCENM), both of which are precise and efficient modeling methodologies. MWCENM considers both the weight of the nucleotides and the chemical bonds between atoms, and SCENM can obtain mode shapes of a whole structure by using only a repeated unit and its connectivity with neighboring units. Our results show the intrinsic vibrational features of DNA ring structures, which experience inner/outer circle and bridge motions, as well as DNA buckyball structures having overall breathing and local breathing motions. These could be used as the fundamental basis for designing and constructing more complicated DNA nanostructures.</P>
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Development of sheared and ultra-pure DNA thin films prepared by ultrasonication and purification
Lee Jayeon,Kokkiligadda Samanth,Mariyappan Karthikeyan,Jo Soojin,Park Suyoun,Tandon Anshula,Jeon Sohee,Jeon Jun-Ho,Park Sung Ha 한국물리학회 2022 Current Applied Physics Vol.37 No.-
DNA solutions were prepared by ultrasonication and purification to compare the characteristics between DNA solutions different in size, purity, or both. Ultrasonication effectively minimized the size variation in native DNA, while purification enhanced the transparency of fabricated DNA thin film. Each DNA solution was used to fabricate water-soluble or organic-soluble thin film. According to the electrical measurement of DNA and CTMAmodified DNA thin films and the fluorescence measurement of PicoGreen-embedded DNA thin films, ultrasonication and purification affect the electrical characteristics and intercalating efficiency of DNA thin films. The electrical properties of the water-soluble thin film and the organic-dissolved thin film were predominantly affected by purification, but opposite tendencies were observed. The highest resistance was observed in watersoluble DNA thin film fabricated from ultra-pure DNA, whereas organic-soluble DNA thin film from ultra-pure DNA showed the lowest resistance. Ultrasonication showed a synergistic effect on PicoGreen-DNA insertion, whereas purification suppressed the fluorescence signal.
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