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Heo, Min,Lee, Sang Jin,Lee, Donghyun,Heo, Dong Nyoung,Lee, Jae Seo,Youn, Yun Hee,Lee, Si Eun,Ko, Na Re,Kim, Byung-Soo,Lim, Ho-Nam,Kwon, Il Keun 한국섬유공학회 2017 Fibers and polymers Vol.18 No.11
<P>Hydrogel-based integral nerve electrodes have been studied as an effective implant strategy for recovery after a spinal cord injury (SCI). However, a weak physical connection between the hydrogel and nerve electrode can lead to implant failure. In this study, we introduce poly(L-lactic acid) (PLA) nanorods (PLANRs) as a new approach to improve the physical property, i.e. stability of agarose hydrogel-based integrated neuro-electrodes. The hydrogels were characterized by scanning electron microscope (SEM), rheometry, and tensile test machine. Thus, the hydrogels containing PLANRs displayed high mechanical properties. These interesting findings suggest that PLANRs enhance the mechanical properties of integral nerve electrode hydrogels making them useful materials in neural tissue engineering.</P>
Sung Youn Heo,You Na Seo,Won Seok Ju,Hyun Gyu Lim,Sang-Young Seo,Jin Hyoung Cho,Park Soon Ju,Young-Kug Choo 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
Macrophages, the cells of the innate immune system, play a key role in all three types of xenograft rejection. However, the mechanism underlying their direct effects is incompletely understood. To study the direct effects of macrophages, established human model system combined the U937 monocyte cell line and mini-pig adipose derived mesenchymal stem cells (mp AD-MSCs). Treatment of mp AD-MSCs with macrophage secretion medium (Macro SM) markedly reduced the cell viability, increased lactate dehydrogenase release, and induced apoptotic cell death. The proteomic analysis identified 17 proteins in Macro SM. Based on the gene ontology analysis tool, matrix metalloproteinase (MMP)-9 was selected as the protein affecting MSC viability. To confirm the effect of MMP-9, cells were treated with recombinant human MMP-9 that resulted in decreased cell viability and increased lactate dehydrogenase release. These results suggest that MMP-9 may decrease the cell viability by damaging the cell membrane in the co-culture model.
TFN model application for hourly flood prediction of small river
Sung, Ji Youn,Heo, Jun-Haeng 한국수자원학회 2018 한국수자원학회논문집 Vol.51 No.2
시계열 데이터를 활용하는 모형은 신뢰할 수 있는 자료를 확보한 경우에는 모형 구축이 용이하고 예측 선행 시간 확보를 위해 신속한 모의가 가능한 장점 때문에 규모가 작은 하천의 홍수예측 모형으로 고려할 수 있다. 이 중 Transfer Function Noise (TFN) 모형은 이탈리아, 영국 등 해외에서는 1970년대부터 시간단위 자료를 이용한 하천유량 예측에 적용되었으나, 우리나라에서는 주로 일 단위 혹은 월 단위의 하천유량 모의에 적용되었다. 국내 수문 자료의 품질 향상으로 그동안 축적된 수문자료를 통해 시간단위 자료를 이용한 홍수예측 모형의 구축 기반이 갖추어졌다. 본 연구의 목적은 소규모 하천을 대상으로 외생변수의 반영이 가능하고 동적시스템과 오차항을 결합하여 예측 오차를 줄이는데 용이한 TFN 모형을 구축하고 그 적용성을 검토하는 것이다. 이를 위해 1시간 단위 자료를 이용하여 TFN 모형을 구축하였으며 구축된 모형을 이용한 홍수 예측 결과를 홍수예보 실무에 활용 중인 저류함수모형의 홍수 예측 결과와 비교하였다. 비교 결과 홍수사상에 따라 TFN 모형과 저류함수 모형이 각각 더 나은 결과를 보이는 사상이 있었으며, 실무에서 TFN 모형을 홍수예측 모형으로 활용할 수 있을 것으로 판단하였다. The model using time series data can be considered as a flood forecasting model of a small river due to its efficiency for model development and the advantage of rapid simulation for securing predicted time when reliable data are obtained. Transfer Function Noise (TFN) model has been applied hourly flood forecast in Italy, and UK since 1970s, while it has mainly been used for long-term simulations in daily or monthly basis in Korea. Recently, accumulating hydrological data with good quality have made it possible to simulate hourly flood prediction. The purpose of this study is to assess the TFN model applicability that can reflect exogenous variables by combining dynamic system and error term to reduce prediction error for tributary rivers. TFN model with hourly data had better results than result from Storage Function Model (SFM), according to the flood events. And it is expected to expand to similar sized streams in the future.
Sang Hoon Kim,Young Wha Song,Hong Rae Kim,Seo Yoon Heo,Yong Youn Kim 국제물리치료학회 2017 Journal of International Academy of Physical Ther Vol.8 No.1
The purpose of this study was to investigate the effects of hypobarichypoxic training program on competitive performance. This was done by observing their conditioning and measuring their blood constituents before and after a multi-staged intermittent training program, over 2 weeks. Three national handicapped cyclists were placed in a multi-leveled hypobaric-hypoxic (flat–4000 meter (m) high elevation) environment with consistent temperature and humidity (23 ± 2℃, 50 ± 5%) for 2 weeks. After the training, the blood constituents and average heart rate (HR) were measured and the following results were obtained. In all three athletes, there were no unique changes in red blood cell count, hemoglobin, and hematocrit, while there was a rise in the reticulocyte count. Observations of the difference in average HR during exercise at varying altitudes showed that athlete A had an average increase in the HR for the first 5 days at 2000 m. For athlete B, the comparison of the first and last training sessions at an altitude of 2000 m showed an HR increase of approximately 17%. For athlete C, there was a steady increase in the HR until day 7 of the training. As such, hypobarichypoxic training suggested that improvement of aerobic exercise performance in these athletes and it is recommended that there be a development for future training programs at high altitude, geared towards handicapped athletes of various disciplines.
Heo, Ju Young,Kang, Se Hun,Kim, Young-Hwa,You, Suyeon,Jin, Kyeong Sik,Kim, Seung Won,Jung, Hye-youn,Jung, Kyung Oh,Lee, Chul-Hee,Kim, Mi Jung,Sung, Soo-Eun,Kim, Boram,Choi, Insung S.,Youn, Hyewon,Chun Royal Society of Chemistry 2017 Chemical science Vol.8 No.7
<▼1><P>A simple strategy to enhance the tumor-targeting efficiency of PEGylated nanocarriers is demonstrated.</P></▼1><▼2><P>Achieving accurate and efficacious tumor targeting with minimal off-target effects is of paramount importance in designing diagnostic and therapeutic agents for cancer. In this respect, nanocarriers have gained enormous popularity because of their attainable multifunctional features, as well as tumor-targeting potential by extravasation. However, once administered into the bloodstream, nanocarriers face various <I>in vivo</I> obstacles that may significantly impair their performance needed for clinical translation. Herein, we demonstrate a strategy to enhance tumor-targeting efficiency by embedding functionalities in the interior region of partially PEGylated nanocarriers (<I>ca.</I> 10 nm in diameter), intended for active or passive targeting. The cooperative impact of these topologically inner functional groups (IFGs) was marked: enhancements of >100-fold in IC<SUB>50</SUB><I>in vitro</I> (<I>e.g.</I>, a high-avidity ligand with cationic IFGs) and >2-fold in tumor accumulation at 2 h post-injection <I>in vivo</I> (<I>e.g.</I>, a high-avidity ligand with anionic IFGs), both against the fully PEGylated counterpart. Analogous to allosteric modulators, properly employed IFGs may substantially improve the process of effectively directing nanocarriers to tumors, which is otherwise solely dependent on avidity or extravasation.</P></▼2>
Sang Min Youn,Jin Seok Heo,Dong Wook Choi,Seong Hyeon Yun,Ho Kyung Chun,Woo Yong Lee,Seong Ho Choi,Hee Cheol Kim,Yong Bum Cho 한국간담췌외과학회 2010 한국간담췌외과학회지 Vol.14 No.3
Purpose: This study was designed to compare outcomes in patients who underwent hepatectomy or radiofrequency thermal ablation (RFA) for synchronous or metachronous colorectal liver metastases (CLM). Methods: One hundred twenty-two patients who underwent hepatectomy or RFA for their first CLM between 2001 and 2004 were enrolled in this study. The patients were divided into two groups (synchronous [N=77] and metachronous [N=45] CLM). Patient characteristics, clinicopathologic features, long-term outcomes, and prognostic factors were analyzed retrospectively. Results: There were no significant differences in the 5-year disease-free and overall survival rates between the synchronous and metachronous CLM groups (36.2% vs. 37.2%, p=0.78; and 53.0% vs. 54.4%, p=0.82, respectively). Patients in the synchronous CLM group underwent more bilobar hepatic resections, intra-operative RFA, or co-modality treatments than the metachronous CLM group (p=0.035). The surgical resection group had a longer disease-free survival, but not overall survival than the RFA group. Greater N stage and female gender were associated with a worse prognosis in overall survival; N0 stage and surgical resection were good prognostic factors for disease-free survival. N stage and surgical resection were also statistically significant prognostic factors based on multivariate analysis. Conclusion: The synchronicity of CLM is not a significant prognostic factor, but the clinicopathologic characteristics that reflect more disseminated disease than metachronous metastasis are significant prognostic factors. Tumor characteristics and aggressiveness may be more important for prognosis than chronology.
Sung Youn Heo,Dong Hoon Kwak,Yu Na Seo,Won Seok Ju,Hyun Gyu Lim,Seo Yi Lee,Ji-Su Kim,Kyu-Tae Chang,Young-Kug Choo 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.07
Mesenchymal stem cells can differentiate into multiple lineages depending on their exposure to differing biochemical and biomechanical inductive factors. The Ganglioside is included in biomarker, that are the major component of cytoplasmic cell membranes complex glycosphingolipids, and play a role in the control of biological processes. However, role of ganglioside in osteogenesis of mini-pig adipose derived mesenchymal stem cells (AD-MSCs) unclear . We have knocked down was ganglioside synthase UDP-glucose ceramide glucosyltransferase (UGCG)using a siRNA differentiation into osteoblast was markedly decreased in UGCG-knocked down AD-MSCs. The results showed significant inhibits alkaline phosphatase, osteocalcin, osteopontin, and Runt-related transcription factor 2 in UGCG knock down AD-MSCs compared to with the control AD-MSCs. Thus we guess, maybe ganglioside is essential factor to stimulate osteogenesis in AD-MSCs.
Sung Youn Heo,You Na Seo,Won Seok Ju,Hyun Gyu Lim,Sang-Young Seo,Jin Hyoung Cho,Park Soon Ju,Young-Kug Choo 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
Mesenchymal stem cells are undifferentiated stem cells that can differentiate into various cells and tissues. In this study, we confirmed the difference in expression and differentiation rate of gangliosides during the differentiation of mini-pig adipose-derived mesenchymal stem cells into neuronal cells using secretion medium from PMA-induced human macrophage-like cell line U937 (Macro SM). We showed that nm23, one of several proteins secreted in the culture medium of activated human macrophages, decreased the neuronal differentiation rate of mesenchymal stem cells derived from mini-pig adipose, and inhibited the function and the synthesis enzyme of GD3. In conclusion, one of the factors that decreased the differentiation rate of mini-pig adipose-derived mesenchymal stem cells into neuronal cells by Macro SM is the nm23 protein.