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Reference Values for a Panel of Cytokinergic and Regulatory Lymphocyte Subpopulations
Vincenzo Sorrenti,Bruno Marenda,Stefano Fortinguerra,Claudia Cecchetto,Roberta Quartesan,Giulia Zorzi,Morena Zusso,Pietro Giusti,Alessandro Buriani 대한면역학회 2016 Immune Network Vol.16 No.6
Lymphocyte subpopulations producing cytokines and exerting regulatory functions represent key immune elements. Given their reciprocal interdependency lymphocyte subpopulations are usually assayed as diagnostic panels, rather than single biomarkers for specialist clinical use. This retrospective analysis on lymphocyte subpopulations, analyzed over the last few years in an outpatient laboratory in Northeast Italy, contributes to the establishment of reference values for several regulatory lymphocytes currently lacking such reference ranges for the general population. Mean values and ranges in a sample of Caucasian patients (mean age 42±8,5 years), were provided for Th1, Th2, Th17, Th-reg, Tc-reg, Tc-CD57+ and B1 lymphocytes. The results are consistent with what is found in literature for the single subtypes and are: Th1 157.8±60.3/ml (7.3%±2.9); Th2 118.2±52.2/ml (5.4%±2.5); Th17 221.6±90.2/ml (10.5%±4.4); Th-reg 15.1±10.2/ml (0.7%±0.4); Tc-reg 5.8±4.7/ml (0.3%±0.2); Tc-CD57+ 103.7±114.1/ml (4.6%±4.7); B1 33.7±22.8/ml (1.5%±0.9); (Values are mean±SD). The results show that despite their variability, mean values are rather consistent in all age or sex groups and can be used as laboratory internal reference for this regulatory panel. Adding regulatory cells to lymphocyte subpopulations panels allows a more complete view of the state of the subject’s immune network balance, thus improving the personalization and the “actionability” of diagnostic data in a systems medicine perspective.
Thyroid Autoantibodies and Breast Cancer
Prinzi, Natalie,Baldini, Enke,Sorrenti, Salvatore,De Vito, Corrado,Tuccilli, Chiara,Catania, Antonio,Carbotta, Sabino,Mocini, Renzo,Coccaro, Carmela,Nesca, Angela,Bianchini, Marta,De Antoni, Enrico,D' Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Giacomo, Claudia Di,Acquaviva, Rosaria,Sorrenti, Valeria,Vanella, Angelo,Grasso, Salvatore,Barcellona, Maria Luisa,Galvano, Fabio,Vanella, Luca,Renis, Marcella The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
Aerobic exercise increases free radical production as a consequence of enhanced oxygen consumption. If free radical formation exceeds antioxidant capacity, lipids, proteins, and DNA may be oxidized. Oxidative stress is widely recognized as a factor in many degenerative human diseases. The role of dietary antioxidants in protection against disease is a topic of continuing interest. In fact, there is epidemiological evidence correlating a higher intake of nutrients possessing antioxidant abilities with a lower incidence of various human diseases. This study was directed at investigating whether changes in plasma antioxidant capacity and oxidative stress markers occur in voluntary wheel runners, before and after oral supplementation with lycopene and isoflavones. For this purpose, plasma antioxidant capacity and oxidative stress markers were assessed in long distance runners at the end of a 60-minute run. Comparisons were made between runners before and after 60 days of supplementation with lycopene and isoflavones. DNA damage in blood cells of the same samples was also evaluated by comet assay. This investigation shows that oral supplementation with lycopene and soy-derived isoflavones significantly reduced lipid peroxidation and enhanced plasma nonproteic antioxidant defense.
Claudia Di Giacomo,Rosaria Acquaviva,Valeria Sorrenti,Angelo Vanella,Salvatore Grasso,Maria Luisa Barcellona,Fabio Galvano,Luca Vanella,Marcella Renis 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.1
Aerobic exercise increases free radical production as a consequence of enhanced oxygen consumption. If free radical formation exceeds antioxidant capacity, lipids, proteins, and DNA may be oxidized. Oxidative stress is widely recognized as a factor in many degenerative human diseases. The role of dietary antioxidants in protection against disease is a topic of continuing interest. In fact, there is epidemiological evidence correlating a higher intake of nutrients possessing antioxidant abilities with a lower incidence of various human diseases. This study was directed at investigating whether changes in plasma antioxidant capacity and oxidative stress markers occur in voluntary wheel runners, before and after oral supplementation with lycopene and isoflavones. For this purpose, plasma antioxidant capacity and oxidative stress markers were assessed in long distance runners at the end of a 60-minute run. Comparisons were made between runners before and after 60 days of supplementation with lycopene and isoflavones. DNA damage in blood cells of the same samples was also evaluated by comet assay. This investigation shows that oral supplementation with lycopene and soy-derived isoflavones significantly reduced lipid peroxidation and enhanced plasma nonproteic antioxidant defense.