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Song, Min-Kyu,Cheng, Shuang,Chen, Haiyan,Qin, Wentao,Nam, Kyung-Wan,Xu, Shucheng,Yang, Xiao-Qing,Bongiorno, Angelo,Lee, Jangsoo,Bai, Jianming,Tyson, Trevor A.,Cho, Jaephil,Liu, Meilin American Chemical Society 2012 Nano letters Vol.12 No.7
<P>While pseudocapacitors represent a promising option for electrical energy storage, the performance of the existing ones must be dramatically enhanced to meet today’s ever-increasing demands for many emerging applications. Here we report a nanostructured, mixed-valent manganese oxide film that exhibits anomalously high specific capacitance (∼2530 F/g of manganese oxide, measured at 0.61 A/g in a two-electrode configuration with loading of active materials ∼0.16 mg/cm<SUP>2</SUP>) while maintaining excellent power density and cycling life. The dramatic performance enhancement is attributed to its unique mixed-valence state with porous nanoarchitecture, which may facilitate rapid mass transport and enhance surface double-layer capacitance, while promoting facile redox reactions associated with charge storage by both Mn and O sites, as suggested by in situ X-ray absorption spectroscopy (XAS) and density functional theory calculations. The new charge storage mechanisms (in addition to redox reactions of cations) may offer critical insights to rational design of a new-generation energy storage devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-7/nl300984y/production/images/medium/nl-2012-00984y_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl300984y'>ACS Electronic Supporting Info</A></P>
Jeon, Mansik,Song, Wentao,Huynh, Elizabeth,Kim, Jungho,Kim, Jeesu,Helfield, Brandon L.,Leung, Ben Y. C.,Goertz, David E.,Zheng, Gang,Oh, Jungtaek,Lovell, Jonathan F.,Kim, Chulhong SPIE--the International Society for Optical Engine 2014 Journal of biomedical optics Vol.19 No.1
Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Increasingly, photoacoustic and ultrasound have been integrated in terms of hardware instrumentation. To generate a broadly accessible dual-modality contrast agent, we generated microbubbles (a standard ultrasound contrast agent) in a solution of methylene blue (a standard photoacoustic dye). This MB2 solution was formed effectively and was optimized as a dual-modality contrast solution. As microbubble concentration increased (with methylene blue concentration constant), photoacoustic signal was attenuated in the MB2 solution. When methylene blue concentration increased (with microbubble concentration held constant), no ultrasonic interference was observed. Using an MB2 solution that strongly attenuated all photoacoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (>800-fold increase), providing a new method for spatiotemporal control of photoacoustic signal generation. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Chen, Xun,Zhang, Wentao,Zhang, Qian,Song, Tao,Yu, Zirui,Li, Zhong,Duan, Ning,Dang, Xiaoqian Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.6
Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.
YuFang Zhou,Weijun Zhen,YaNan Song,WenTao Wang 한국고분자학회 2015 Macromolecular Research Vol.23 No.12
The partial inclusion complexes (ICs) between poly(L-lactic acid) (PLLA) with high molecular weight and β-cyclodextrin (CD) were prepared and characterized by 1H nuclear magnetic resonance spectra (1H NMR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and polarizing optical microscopy (POM), respectively. The thermal results demonstrated that the crystallization performance of ICs were significantly improved, and the decomposition temperature of ICs were increased compared with PLLA. The mechanical tests indicated that the mechanical performance of ICs was improved, and the β-CD-PLLA ICs exhibited a higher non-Newtonian effect than PLLA. The degradation rate for the partial ICs in phosphate buffer solution accelerated as the ratio of β-CD increased, meanwhile, the partial ICs had a good shape memory behavior. The wetting measurements suggested the hydrophilicity of ICs was also enhanced markedly in comparison with the bulk PLLA.
Lu Dezhi,Yang Yang,Zhang Pingping,Ma Zhenjiang,Li Wentao,Song Yan,Feng Haiyang,Yu Wenqiang,Ren Fuchao,Li Tao,Zeng Hong,Wang Jinwu 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6
Spinal cord injury (SCI) is a disabling and destructive central nervous system injury that has not yet been successfully treated at this stage. Three-dimensional (3D) bioprinting has become a promising method to produce more biologically complex microstructures, which fabricate living neural constructs with anatomically accurate complex geometries and spatial distributions of neural stem cells, and this is critical in the treatment of SCI. With the development of 3D printing technology and the deepening of research, neural tissue engineering research using different printing methods, bio-inks, and cells to repair SCI has achieved certain results. Although satisfactory results have not yet been achieved, they have provided novel ideas for the clinical treatment of SCI. Considering the potential impact of 3D bioprinting technology on neural studies, this review focuses on 3D bioprinting methods widely used in SCI neural tissue engineering, and the latest technological applications of bioprinting of nerve tissues for the repair of SCI are discussed. In addition to introducing the recent progress, this work also describes the existing limitations and highlights emerging possibilities and future prospects in this field.
Liu Qian,Fan Guoying,Wu Kui,Bai Xiangning,Yang Xi,Song Wentao,Chen Shengen,Xiong Yanwen,Chen Haiying 한국미생물학회 2022 The journal of microbiology Vol.60 No.7
Two novel Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, and short rods to coccoid strains were isolated from the feces of the greater white-fronted geese (Anser albifrons) at Poyang Lake. The 16S rRNA gene sequences of strains 4H37-19T and 3HC-13 shared highest identity to that of Corynebacterium uropygiale Iso10T (97.8%). Phylogenetic and phylogenomic analyses indicated that strains 4H37-19T and 3HC-13 formed an independent clade within genus Corynebacterium and clustered with Corynebacterium uropygiale Iso10T. The average nucleotide identity and digital DNA-DNA hybridization value between strains 4H37-19T and 3HC-13 and members within genus Corynebacterium were all below 95% and 70%, respectively. The genomic G + C content of strains 4H37-19T and 3HC-13 was 52.5%. Diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylcholine, and phosphatidyl inositol mannosides (PIM) were the major polar lipids, with C18:1ω9c, C16:0, and C18:0 as the major fatty acids, and MK-8 (H4), MK-8(H2), and MK-9(H2) as the predominant respiratory quinones. The major whole cell sugar was arabinose, and the cell wall included mycolic acids. The cell wall peptidoglycan contained meso-diaminopimelic acid (meso-DAP). The polyphasic taxonomic data shows that these two strains represent a novel species of the genus Corynebacterium, for which the name Corynebacterium poyangense sp. nov. is proposed. The type strain of Corynebacterium poyangense is 4H37-19T (=GDMCC 1.1738T = KACC 21671T).