A Research & Development Framework of Successful Rolling Out Strategies for e-Learning Courses

( Soe Soe Khaing ),( Aung Win ) 한국교육공학회 2014 한국교육공학회 학술대회발표자료집 Vol.2014 No.2

Developing e-learning courses for higher education is very important. Because e-learning is just as effective as any face-toface learning and it includes all part of a ``blended`` learning approach. Moreover e-learning service plays an important role in providing to enhance lifelong learning and provide unlimited opportunities for personal growth and development to all. This paper intends to carry out research and development framework of the e-learning course distribution of the lessons learned from two years`` experience and to identify the current challenges and to make some suggestions for the future. Rolling out strategies for e-learning courses is based on network infrastructure, interest of e-learning and learning environment. Based on these various factors, it will use statistical analysis and some methods and strategies to rolling out the contents to other universities. This research will contribute to strengthen the successful implementation of e-learning operation in some universities under ministry of science and technology, Myanmar.

Comparison of Microscopy, Nested-PCR, and Real-Time-PCR Assays Using High-Throughput Screening of Pooled Samples for Diagnosis of Malaria in Asymptomatic Carriers from Areas of Endemicity in Myanmar

Wang, Bo,Han, Soe-Soe,Cho, Cho,Han, Jin-Hee,Cheng, Yang,Lee, Seong-Kyun,Galappaththy, Gawrie N. L,Thimasarn, Krongthong,Soe, Myat Thu,Oo, Htet Wai,Kyaw, Myat Phone,Han, Eun-Taek American Society for Microbiology 2014 Journal of clinical microbiology Vol.52 No.6

<P>Asymptomatic infection is an important obstacle for controlling disease in countries where malaria is endemic. Because asymptomatic carriers do not seek treatment for their infections, they can have high levels of gametocytes and constitute a reservoir available for new infection. We employed a sample pooling/PCR-based molecular detection strategy for screening malaria infection in residents from areas of Myanmar where malaria is endemic. Blood samples (<I>n</I> = 1,552) were collected from residents in three areas of malaria endemicity (Kayin State, Bago, and Tanintharyi regions) of Myanmar. Two nested PCR and real-time PCR assays showed that asymptomatic infection was detected in about 1.0% to 9.4% of residents from the surveyed areas. The sensitivities of the two nested PCR and real-time PCR techniques were higher than that of microscopy examination (sensitivity, 100% versus 26.4%; kappa values, 0.2 to 0.5). Among the three regions, parasite-positive samples were highly detected in subjects from the Bago and Tanintharyi regions. Active surveillance of residents from regions of intense malaria transmission would reduce the risk of morbidity and mitigate transmission to the population in these areas of endemicity. Our data demonstrate that PCR-based molecular techniques are more efficient than microscopy for nationwide surveillance of malaria in countries where malaria is endemic.</P>

BiSpark: a Spark-based highly scalable aligner for bisulfite sequencing data

Soe, Seokjun,Park, Yoonjae,Chae, Heejoon BioMed Central 2018 BMC bioinformatics Vol.19 No.1

<P><B>Background</B></P><P>Bisulfite sequencing is one of the major high-resolution DNA methylation measurement method. Due to the selective nucleotide conversion on unmethylated cytosines after treatment with sodium bisulfite, processing bisulfite-treated sequencing reads requires additional steps which need high computational demands. However, a dearth of efficient aligner that is designed for bisulfite-treated sequencing becomes a bottleneck of large-scale DNA methylome analyses.</P><P><B>Results</B></P><P>In this study, we present a highly scalable, efficient, and load-balanced bisulfite aligner, BiSpark, which is designed for processing large volumes of bisulfite sequencing data. We implemented the BiSpark algorithm over the Apache Spark, a memory optimized distributed data processing framework, to achieve the maximum data parallel efficiency. The BiSpark algorithm is designed to support redistribution of imbalanced data to minimize delays on large-scale distributed environment.</P><P><B>Conclusions</B></P><P>Experimental results on methylome datasets show that BiSpark significantly outperforms other state-of-the-art bisulfite sequencing aligners in terms of alignment speed and scalability with respect to dataset size and a number of computing nodes while providing highly consistent and comparable mapping results.</P><P><B>Availability</B></P><P>The implementation of BiSpark software package and source code is available at https://github.com/bhi-kimlab/BiSpark/.</P>

A Study on Design of Robotic Gripper and Cutting Tool for Mango Fruit Harvesting

( Soe Hlaing ),( Yong-tae Kim ) 한국농공학회 2018 한국농공학회 학술대회초록집 Vol.2018 No.-

Nowadays, decreasing labor populations due to a variety of reasons has led to the increase in labor costs, high input energy consumption and other problems. To solve this challenging task, providing long term and high-tech alternatives is required to boost the efficiency and profitability of the farmers. Hence an automated system that is low cost and easy to use is to be provided. The main objectives are gather all information on fruit harvesting grippers; focus on the technical developments and discuss the future prospects of mango fruit harvesting gripper for robot. Approaches the design problem of suitable grippers for a robotic arm to pluck mango fruit in horticulture. General considerations have been pointed out. Main concepts and mechanical designs have been discussed and proposed by sketches and drawings for an easy understanding of problems and feasible solutions. The mechanical system represents a picking system which composed of two parts; the first part is aimed at grasping the mango and the second part is aimed at cutting the stem of mango from plant. These both parts show the concept of the new gripping and cutting tool designed to harvest the mango. I used the gear gripper of translation movement with two fingers. The mechanism of end-effector is determined by operation and biological characteristics of the target object. A spoon-shaped end-effector is designed according to biological characteristics of spherical fruit, which are picked by means of cutting off the stalk. The end-effector contained the following parts: a gripper to grasp the fruit and a scissor cutting device to separate the fruit from the stalk. Used of CM 530 controller to control the dynamixel servo motors for opening and closing of gripper and cutter rotating. During the process of clamping the fruit, it required pressure sensor to control the grasping force accurately. In addition, the rotation of arm, its traveling position and accurate capture also required the position sensor to detect and locate fruit.

Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy

Soe, Zar Chi,Thapa, Raj Kumar,Ou, Wenquan,Gautam, Milan,Nguyen, Hanh Thuy,Jin, Sung Giu,Ku, Sae Kwang,Oh, Kyung Taek,Choi, Han-Gon,Yong, Chul Soon,Kim, Jong Oh Elsevier 2018 Colloids and surfaces Biointerfaces Vol.170 No.-

<P><B>Abstract</B></P> <P>Drug targeting using functionalized nanoparticles provides a new standard in anticancer therapy. Liposomes, safe and effective drug delivery carriers, can incorporate both hydrophilic and hydrophobic drugs for combination chemotherapy treatment of cancers. The objectives of the current study were to synthesize and test the effectiveness of a nanotechnology-based strategy utilizing folic acid (FA)-conjugated liposomes that incorporate both celastrol (Cs) and irinotecan (Ir) for targeted breast cancer therapy. Our results revealed the successful preparation of Cs and Ir-loaded folate-targeted liposomes (Lipo/Cs/Ir-FA) with a small particle size (∼190 nm) and polydispersity index (∼0.10). The formulation exhibited higher drug release profiles for both Ir and Cs at pH 5.0 compared to those at physiological pH, favoring cancer cell-targeted release. Furthermore, <I>in vitro</I> cell studies showed high uptake and enhanced apoptosis in folate receptor-positive breast cancer cells (MCF-7 and MDA-MB-231), but not in folate receptor-negative lung cancer cells (A549). Moreover, an <I>in vivo</I> study in a mouse tumor model using MDA-MB-231 xenografts supported effective drug delivery behavior of the folate-conjugated liposomes by selective targeting of tumor tissue and minimizing systemic adverse effects. Therefore, our formulation could provide an effective therapy for targeted cancer treatment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Folate-conjugated liposomes incorporating celastrol and irinotecan were synthesized. </LI> <LI> The formulation exhibited higher drug release profiles at pH 5.0 than at pH 7.4. </LI> <LI> <I>In vitro</I> studies showed high uptake in folate receptor-positive breast cancer cells. </LI> <LI> A mouse model showed effective drug targeting of tumors with minimal adverse effects. </LI> <LI> Our formulation could provide an effective therapy for targeted cancer treatment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Asian Folktales for Teaching English in Asia

Soe Marlar Lwin 아시아영어교육학회 2017 The Journal of Asia TEFL Vol.14 No.4

Optimization of efficient protocorm-like body (PLB) formation of Phalaenopsis and Dendrobium hybrids

Soe, Khaing Wah,Myint, Khin Thida,Naing, Aung Htay,Kim, Chang Kil Institute of Agricultural Science and Technology 2014 慶北大農學誌 Vol.32 No.4

Optimization of the protocorm-like body (PLB) formation of Phalaenopsis and Dendrobium hybrids was performed by determining the effects of plant growth regulators (PGRs) and different parts and division sizes of the PLB. For both genera, the base part was the best for the proliferation of PLBs, yielding the highest number of PLBs on a PGR-free medium for Phalaenopsis and medium containing $0.1{\mu}M$ NAA and $10.0{\mu}M$ BAP for Dendrobium. As regards the division size, four-division sections resulted in a higher PLB formation efficiency for Phalaenopsis, while two-division sections produced a higher PLB formation efficiency for Dendrobium. It is expected that these findings will be applicable to efficient PLB formation of other Phalaenopsis and Dendrobium orchids.

A Study on English-Teaching Method for Hotel Employees

Soe, Jin-Wook 문화관광연구학회 2001 문화관광연구 Vol.3 No.4

88 올림픽이래 다가오는 '월드컵 2002'는 한국관광산업의 또 하나의 도약의 계기로써 외국관광객에 대한 서비스 관련 종사원의 서비스 교육과 훈련이 어느 때 보다 중요하게 인식되고 있다. 특히, 국제화된 환경 속에서 오늘날의 호텔은 고용인들의 서비스 역량에 의해 고객만족에 큰 영향을 주는 서비스 산업 중에 하나로 Global Standard 수준의 서비스 제공을 필요로 하고 있다. 외국인과의 접촉이 많은 호텔에서의 보다 큰 고객 만족을 위한 서비스의 첫 번째 요건은 언어소통이라 할 수 있겠다. 이 연구의 목적은 호텔 종업원의 영어교육을 보다 효과적으로 수행할 수 있는 교육방법을 연구하는데 있다.

Ⅱ. Recent trends of agricultural mechanization policy and market demands in Myanmar

( Soe Hlaing ) 한국농업기계학회 2018 KIEMSTA 심포지엄 Vol.2018 No.-

A Rare Presentation of Metastasis of Prostate Adenocarcinoma to the Stomach and Rectum

Soe, Aye Min,Bordia, Sonal,Xiao, Philip Q.,Lopez-Morra, Hernan,Tejada, Juan,Atluri, Sreedevi,Krishnaiah, Mahesh The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.4

Prostate cancer is the second most common cause of cancer death in men in the United States. The most common sites of metastasis include the bone, lymph nodes, lung, liver, pleura, and adrenal glands, whereas metastatic prostate cancer involving the gastrointestinal tract has been rarely reported. A 64-year-old African-American man with a history of prostate cancer presented with anemia. He reported the passing of dark colored stools but denied hematemesis or hematochezia. Colonoscopy revealed circumferential nodularity, and histology demonstrated metastatic carcinoma of the prostate. Esophagogastroduodenoscopy showed hypertrophic folds in the gastric fundus, and microscopic examination revealed tumor cells positive for prostate-specific antigen. Bone scanning and computed tomography of the abdomen and pelvis did not show metastasis. It is crucial to distinguish primary gastrointestinal cancer from metastatic lesions, especially in patients with a history of cancer at another site, for appropriate management.