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      • Antitumor and antioxidant activities of Bryonia laciniosa against Ehrlich's Ascites Carcinoma bearing Swiss albino mice

        Sivakumar, T,Kumar, R Sambath,Perumal, P,Vamsi, MLM,Sivakumar, P,Kanagasabai, R,Baskaran, MV,Karki, Subhas S,Mazumder, UK,Gupta, M Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.4

        The plant Bryonia laciniosa (Family: Cucurbitaceae) has been indicated for the treatment of various diseases one among which is cancer. The purpose of this study was investigating experimentally the possible anti-tumor effect and antioxidant role of Bryonia laciniosa leaves in animal model. The methanol extract of Bryonia laciniosa (MEBL) administered at the doses of 62.5, 125 and 250 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of MEBL on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were estimated. Treatment with MEBL decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of MEBL also decreases the levels of lipid peroxidation and increased the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). The present work indicates that the methanol extract of Bryonia laciniosa exhibited significant antitumor and antioxidant activity in vivo.

      • SCIESCOPUSKCI등재

        Design and FPGA Implementation of FBMC Transmitter by using Clock Gating Technique based QAM, Inverse FFT and Filter Bank for Low Power and High Speed Applications

        Sivakumar, M.,Omkumar, S. The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.6

        The filter bank multicarrier modulation (FBMC) technique is one of multicarrier modulation technique (MCM), which is mainly used to improve channel capacity of cognitive radio (CR) network and frequency spectrum access technique. The existing FBMC System contains serial to parallel converter, normal QAM modulation, Radix2 inverse FFT, parallel to serial converter and poly phase filter. It needs high area, delay and power consumption. To further reduce the area, delay and power of FBMC structure, a new clock gating technique is applied in the QAM modulation, radix2 multipath delay commutator (R2MDC) based inverse FFT and unified addition and subtraction (UAS) based FIR filter with parallel asynchronous self time adder (PASTA). The clock gating technique is mainly used to reduce the unwanted clock switching activity. The clock gating is nothing but clock signal of flip-flops is controlled by gate (i.e.) AND gate. Hence speed is high and power consumption is low. The comparison between existing QAM and proposed QAM with clock gating technique is carried out to analyze the results. Conversely, the proposed inverse R2MDC FFT with clock gating technique is compared with the existing radix2 inverse FFT. Also the comparison between existing poly phase filter and proposed UAS based FIR filter with PASTA adder is carried out to analyze the performance, area and power consumption individually. The proposed FBMC with clock gating technique offers low power and high speed than the existing FBMC structures.

      • KCI등재

        Influence of combined radial location and growth on the leakage performance of a rotating labyrinth gas turbine seal

        Sivakumar Subramanian,A. S. Sekhar,B. V. S. S. S. Prasad 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.6

        Leakage characteristics, influenced by centrifugal and thermal radial growth are determined computationally for a generic rotating labyrinthseal used in the gas turbine secondary air system. Three seal locations, namely, R25, R50 and R75 are represented by means ofvarying the rotor radius mimicking different radial positions of the seal from the shaft axis. The combined influence of seal location andits radial (Centrifugal and thermal) growth on the leakage performance is investigated for a wide-ranging speeds from 1000 to 3000 rad/s,temperatures ranging from 200 to 450 oC and pressure ratios varying from 1.1 to 2.5, for a chosen initial clearance of 500 micron. Acomparison of the effect of rotation and temperature gradient among different rotors shows that the radial growth and leakage flow ratessignificantly vary with the increasing radius.

      • SCIESCOPUSKCI등재

        Enhanced Controller Topology for Photovoltaic Sourced Grid Connected Inverters under Unbalanced Nonlinear Loading

        Sivakumar, P.,Arutchelvi, Meenakshi Sundaram The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.2

        A growing dynamic electrical demand has created an increasing interest in utilizing nonconventional energy sources like Photovoltaic (PV), wind power, etc. In this context, this paper focuses on the design and development of a composite power controller (CPC) in the decoupled double synchronous reference frame (DDSRF) combining the advantages of direct power control (DPC) and voltage oriented control (VOC) for a PV sourced grid connected inverter. In addition, a controller with the inherent active filter configuration is tested with nonlinear and unbalanced loads at the point of common coupling in both grid connected and autonomous modes of operation. Furthermore, the loss and reactive power compensation due to a non-fundamental component is also incorporated in the design, and the developed DDSRF model subsequently allows independent active and reactive power control. The proposed developed model of the controller is also implemented using MATLAB-Simulink-ISE and a Xilinx system generator which evaluate both the simulated and experimental setups. The simulation and experimental results confirm the validity of the developed model. Further, simulation results for the DPC are also presented and compared with the proposed CPC to further bring out the salient features of the proposed work.

      • KCI등재

        Meat Quality and Physicochemical Trait Assessments of Berkshire and Commercial 3-way Crossbred Pigs

        Sivakumar Allur Subramaniyan,강다래,Shah Ahmed Belal,조은소리,정종현,정영철,최양일,심관섭 한국축산식품학회 2016 한국축산식품학회지 Vol.36 No.5

        In this study, we compared qualities and physiochemical traits of meat from Berkshire (black color) pigs with those of meat from 3-way Landrace (white color) × Yorkshire (white color) × Duroc (red color) crossbred pigs (LYD). Meat quality characteristics, including pH, color, drip loss, cooking loss, and free amino acid, fatty acid, vitamin, and mineral contents of longissimus dorsi muscles, were compared. Meat from Berkshire pigs had deeper meat color (redness), higher pH, and lower drip loss and cooking loss than meat from LYD pigs. Moreover, meat from Berkshire pigs had higher levels of phosphoserine, aspartic acid, threonine, serine, asparagine, α-aminoadipic acid, valine, methionine, isoleucine, leucine, tyrosine, histidine, tryptophan, and carnosine and lower levels of glutamic acid, glycine, alanine, and ammonia than did meat from LYD pigs. The fatty acids oleic acid, docosahexaenoic acid (DHA), and monounsaturated fatty acids (MUFA) were present in significantly higher concentrations in Berkshire muscles than they were in LYD muscles. Additionally, Berkshire muscles were significantly enriched with nucleotide components (inosine), minerals (Mg and K), and antioxidant vitamins such as ascorbic acid (C) in comparison with LYD muscles. In conclusion, our results show that in comparison with LYD meat, Berkshire meat has better meat quality traits and is a superior nutritional source of all essential amino acids, monounsaturated fatty acids, vitamin C, and minerals (Mg and K).

      • Recent Advances in the Cultivation and to Enhance the Active Components of Ganoderma lucidum

        Sivakumar Manickam,Surya Sudheer,Zain Taha 한국버섯학회 2017 버섯 Vol.21 No.2

        Ganoderma lucidum is one of the most popular medicinal mushrooms of Asian region having promising immune enhancing properties. This single species of mushroom has over 400 bioactive compounds and possess properties relating to battling tumours, viruses, bacteria, inflammation, platelet-aggregation, immune system modulation among many others. There are documented reports of G. lucidum fighting the activity against HIV/AIDS and diabetes. Owing to such a wide range of medicinal applications, the global consumption of G. lucidum is high, which has resulted in a plethora of commercially available patented products. These products have G. lucidum as an active constituent and are usually marketed as food supplements but are also available in the form of creams, hair tonics and medicinal soaps. The growing demand and the high cost of G. lucidum in the local market have enforced to think about a range of novel methods for the cultivation of this mushroom. We explored different novel strategies in this direction. In the first approach, the widely available agricultural residues of oil palm biomass (empty fruit bunch fibres, EFB) from Malaysia were used to cultivate this mushroom with cheap cost. The required conditions for the growth of this mushroom were studied by employing a pilot-scale cultivation in a mushroom farm. From the results it was scrutinized that oil palm waste fibres are the potential source of cultivating G. lucidum either alone or in combination of substrates. In the second strategy, the effect of UV-C radiation on the physical growth of G. lucidum mycelium has shown positive results. Results of 10 and 15 min of UV-C exposure treatments per 24 h showed a 30% increase in the diameter of mycelium over control in Potato Dextrose Agar medium petri-plates. Using EFB as substrates not only supports the G. lucidum cultivation but also offers a viable alternative for the management of solid waste in oil palm plantations of Malaysia. These results stipulate a better and stronger mushroom in terms of its bioactive compounds content and better growth parameters. Moreover, it also benefits the local mushroom farmers in Malaysia for the easy availability of the substrate materials and with better economy. The techniques involved can be propagated to the local Ganoderma industry for improvised cultivation for better output. A high output would also mean profitable business resulting in revolutionizing the economics of Ganoderma markets all over the world.

      • KCI등재후보

        Biodiversity of Microalgae and Their Elemental Components from Veeranam Lake, Tamilnadu, India

        Sivakumar, K.,Senthilkumar, R. The Korean Society of Limnology 2008 생태와 환경 Vol.37 No.1

        An attempt was made in the Veeranam freshwater lake with the objectives to collect, identify, describe and document the algae occurring from March 2007 to August 2007. Qualitative and quantitative characterization of phytoplankton and analysis of physico-chemical parameters of water samples were carried out at monthly intervals during the study period in the western and eastern sides of the lake. It was found that the phytoplankton community embraced 68 genera belonging to four classes viz., Bacillariophyceae (40), Chlorophyceae (22), Cynophyceae (4) and Euglenophyceae (2). There were significant influences of various physico-chemical parameters on the phytoplankton population density. Commonly occurred genera, Oscillatoria (Cyanophyceae), Navicula (Bacillariophyceae) and Scenedesmus (Chlorophyceae), were subjected to energy dispersive spectroscopic analysis (EDS). They were found to accumulate different elements such as Zn, P, S, Ca, Mg, Fe, N, Si, Cl and Mn. Among these the member Cyanophyceae contained Zn, P, Mg, Ca, Mn, S and N. Bacillariophyceae Si, Zn, Mg, Cl, N, Fe, and Ca. Chlorophyceae Ca, Mg, N, Fe, Cl, Zn, Si and Mn. Thus these observations would determine the chemical dialogue between the cell structures and role of the elements. Further, it gives the clue about the phytoplankton growth requirements.

      • SCISCIESCOPUS

        Antiapoptotic effect of a novel synthetic peptide from bovine muscle and MPG peptide on H2O2-induced C2C12 cells.

        Sivakumar, Allur Subramaniyan,Ochirbat, Chinzorio,Cho, Soo-Hyun,Yang, Jieun,Hwang, Inho Springer 2014 In vitro cellular & developmental biology Animal Vol.50 No.7

        <P>The objective of this study was to evaluate antioxidant and antiapoptotic effects of a novel peptide (T.peptide) isolated from bovine and commercially available MPG peptide. The amino acid sequences of the T.peptide were (Glu-Val-Pro-Glu-Val-His-Glu-Glu-Val). The antioxidant activities of these peptides were determined by measuring the 1,1-diphenyl-2-picrylhydrazyl (DPPH?) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS+?) radical scavenging assays. The in vitro cytotoxicity of T.peptide and MPG peptide was determined against H2O2-induced C2C12 cells. H2O2-induced apoptosis in C2C12 cells were determined by mRNA expression of caspase-3. Moreover, the mRNA expression of tumor necrosis factor alpha (TNF-α) and nuclear factor kappa B (NF-κB) were assayed by reverse transcription polymerase chain reaction. The findings of the study indicate that the mRNA expression of TNF-α and NF-κB are significantly (p?<?0.05) increased in H2O2-induced C2C12 cells, whereas a significant decrease (p?<?0.05) in these mRNA expressions are observed when pretreated with T.peptide or MPG peptide. Pretreatment with MPG or T.peptides is also found to significantly (p?<?0.05) decrease the mRNA expression of caspase-3 in H2O2-induced C2C12 cells. The results of the study demonstrate that both T.peptide and MPG peptide could reduce the DPPH? and ABTS+? radical and inhibit cytotoxicity against H2O2-induced injury, resulting in prevention of free radical generation and subsequent apoptotic cell death, which indicates the potential of bovine meat as a source of antioxidant peptides.</P>

      • KCI등재

        Drying and energy aspects of tapioca sago processing-An experimental field study

        Sivakumar R.,Elayaperumal A.,Saravanan R. 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.6

        The drying characteristics of tapioca sago were studied using four different drying methods--Open sun drying (OSD), Conveyor beltdrying (CBD), Bin drying (BD) and Fluidized bed drying (FBD)--in an industry located in Tamilnadu, India (Latitude: 11.494347° N;Longitude: 78.272264° E). The BD and FBD dryers were designed and fabricated as pilot scale models in the laboratory with respectivecapacity of 5 kg/h and 10 kg/h; CBD (1000 kg/h) and OSD are the commercial drying operations currently employed in industrial processing. The drying time, energy and exergy aspects of all the drying methods were compared along with the achieved final moisture content,color and quality of the dried products. The highest Energy utilization ratio (EUR) was found in CBD and FBD in the range of 20-76 % and 10-67 %, respectively. The exergy efficiency was initially low in all the cases but increased to 80 % towards the end of thedrying process.

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