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RISS 인기검색어
- 검색키워드
- 저자 : Shazia Bashir (검색결과 2 건)
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Dynamic Wetting in Microfluidic Droplet Formation
Shazia Bashir,Xavier Casadevall i Solvas,Muhammad Bashir,Julia Margaret Rees,William Bauer Jay Zimmerman 한국바이오칩학회 2014 BioChip Journal Vol.8 No.2
The extent to which the carrier fluid wets the walls of a microchannel is crucial in the droplet formation process for segmented flow microfluidic applications and can be influenced by the use of surfactants. Surfactants dynamically modify the microchannel surface leading to stabilization of the two phase interface, affecting the droplet formation process. An experimental study of the influence of hydrophobic surfactant (Span 80) during the formation of water-inoil droplets in a T-shaped microchannel geometry is presented and the wetting properties of the microchannel walls were characterized. The range of data to be analyzed on the microscale is estimated from the macroscopic interfacial tension and contact angle measurements. The critical micelle concentration (CMC) level at the microscale was estimated by observing the trend of droplet length variation with concentration of surfactant in a microchannel. Microchannels used in this work were fabricated using softlithography methods and bonded using a custom-made plasma bonding setup that does not require an ultra high vacuum chamber and hence saves the fabrication cost.
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Indigenous Radiosynthesis of [131I]Iodobenzylguanidine ([131I]mIBG) for Neuroblastoma Imaging
Nadeem Ahmed Lodhi,Muhammad Irfan,Muhammad Nasir Saddique,Kahkshan Bashir Mir,Naseer Ahmed,Shazia Fatima,Mumtaz Khan,Muhammad Wasim,Samina Roohi 대한방사성의약품학회 2022 Journal of radiopharmaceuticals and molecular prob Vol.8 No.2
Indigenous diagnostic dose of 131I-labeled meta-iodobenzylguanidine ([131I]mIBG) was prepared via Cu+ catalyzed isotope exchange reaction generated in situ by sodium metabisulfite for imaging of neuroblastoma tumor. [131I]mIBG was produced in overall 85-90% radiochemical yield. The average amount of radioactivity of [131I]mIBG was 2164 MBq (1998-2331MBq) with an average specific activity > 1000 MBq/mg at the end of synthesis. The radiochemical purity was ≥ 99.9% after purification through Dowex-1 × 8 ion exchange resin (100-150 mesh) at the date of preparation. The stability of [131I]mIBG at concentration 480-555 MBq/mL was > 97% at 4 °C after 4 days. The room temperature (25 °C) stability of [131I]mIBG was > 98% after 24 h. Biodistribution of [131I]mIBG in patient showed uptake in salivary glands, liver, spleen and excreted though urinary bladder. Neuroendocrine medicated uptake into tumor lesion and metastatic sites were noted which strongly correlate with the morphological abnormalities of patient.
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