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Júlia Vendrell-Serres,Óscar Soto-Angona,Amanda Rodríguez-Urrutia,Benedetta Inzoli,Antonia López González,Josep Antoni Ramos-Quiroga 대한정신약물학회 2024 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.22 No.1
Objective: Treatment Resistant Depression (TRD) is commonly defined as the lack of response to two or more antidepressants with different mechanisms of action. Up to 30% of patients diagnosed with major depressive disorder might be considered to present TRD. The objective of this study was to assess the effectiveness and tolerability of esketamine in patients diagnosed with TRD, who were referred to our program after exhausting all available treatments. A secondary objective consisted in researching the relationship between response and previous use of electroconvulsive therapy. Methods: A prospective, observational study was carried out in patients enrolled in the expanded use of esketamine in our center. They received esketamine prior to its marketing authorisation, for therapeutic purposes. Sixteen subjects were analyzed. Effectiveness was assessed with the Montgomery-Asberg depression rating scale (MADRS). Patients were followed up to 4 months after the administration. Results: Esketamine showed a rapid, robust effect in improving depressive symptoms, with no specific correlation between outcome and any demographic or clinical traits evaluated. No differences were found between patients that previously received Electroconvulsive Therapy, and those that didn’t. 10 out of 16 patients responded (> 50% change in baseline MADRS scores), but only five achieved remission (< 12 points in the global MADRS score). We provide some recommendations, based on clinical experience, to improve tolerability and adherence, and to manage adverse effects. Conclusion: Results suggest that esketamine is a safe, effective and rapid-acting option for TRD. More studies are needed to properly assess predictors of response outcome.
78 fs SWCNT-SA mode-locked Tm:CLNGG disordered garnet crystal laser at 2017 nm
Wang, Yicheng,Zhao, Yongguang,Pan, Zhongben,Bae, Ji Eun,Choi, Sun Young,Rotermund, Fabian,Loiko, Pavel,Serres, Josep Maria,Mateos, Xavier,Yu, Haohai,Zhang, Huaijin,Mero, Mark,Griebner, Uwe,Petrov, Val The Optical Society 2018 Optics letters Vol.43 No.17
Hong, S.,Lee, Y. M.,Cho, K. B.,Seo, M.,Song, D.,Yoon, J.,Garcia-Serres, R.,Clemancey, M.,Ogura, T.,Shin, W. THE ROYAL SOCIETY OF CHEMISTRY 2014 Chemical Science Vol.5 No.1
The mechanism of the alkylperoxo O-O bond cleavage of low-spin iron(III)-alkylperoxo species has been well established in nonheme iron models. In contrast, the alkylperoxo O-O bond cleavage in nonheme high-spin iron(III)-alkylperoxo species binding an axial ligand has yet to be elucidated. Herein, we report the synthesis and characterization of mononuclear nonheme high-spin iron(III)-alkylperoxo complexes each bearing an N-tetramethylated 13-membered macrocyclic ligand (13-TMC), [Fe-III(OOC(CH3)(3))-(13-TMC)](2+) and [Fe-III(OOC(CH3)(2)C6H5)(13-TMC)](2+). The high-spin iron(III)-alkylperoxo complexes were converted to an iron(IV)-oxo complex at a fast rate upon addition of thiocyanate (NCS ) via the formation of a short-lived intermediate. This intermediate was identified as a high-spin iron(III)alkylperoxo complex binding a thiocyanate ion as an axial ligand by characterizing it with various spectroscopic methods and density functional theory (DFT) calculations. We have also provided strong evidence that conversion of the high-spin iron(III)-alkylperoxo complex to its corresponding iron(IV)-oxo complex occurs via O-O bond homolysis. Thus, we have concluded that the role of the axial ligand binding to a high-spin iron(III)-alkylperoxo complex is to facilitate the alkylperoxo O-O bond cleavage via the ' push effect', which has been well established in heme enzymes. To the best of our knowledge, the present study reports the first clear example showing the O-O bond homolysis of a high-spin iron(III)-alkylperoxo complex and the axial ligand effect on the alkylperoxo O-O bond cleavage in nonheme iron models.
Seo, Mi Sook,Kim, Nam Hee,Cho, Kyung-Bin,So, Jeong Eun,Park, Seon Kyung,Clé,mancey, Martin,Garcia-Serres, Ricardo,Latour, Jean-Marc,Shaik, Sason,Nam, Wonwoo Royal Society of Chemistry 2011 Chemical science Vol.2 No.6
<P>A highly reactive mononuclear nonheme iron(<SMALL>IV</SMALL>)-oxo complex with a low-spin (<I>S</I> = 1) triplet ground state in both C–H bond activation and oxo transfer reactions is reported; this nonheme iron(<SMALL>IV</SMALL>)-oxo complex is more reactive than an iron(<SMALL>IV</SMALL>)-oxo porphyrin π-cation radical (<I>i.e.</I>, a model of cytochrome P450 compound I) and is the most reactive species in kinetic studies among nonheme iron(<SMALL>IV</SMALL>)-oxo complexes reported so far. DFT calculations support the experimental results with extremely low activation barriers in the C–H bond activation of cyclohexane and 1,4-cyclohexadiene. The DFT calculations reveal that the <I>S</I> = 1 state is set up to easily lead to the highly reactive <I>S</I> = 2 high-spin iron(<SMALL>IV</SMALL>)-oxo species.</P> <P>Graphic Abstract</P><P>A mononuclear nonheme iron(<SMALL>IV</SMALL>)-oxo complex with a ground low-spin (<I>S</I> = 1) triplet state is found to be a powerful oxidant in both C–H bond activation and oxo transfer reactions and more reactive than a cytochrome P450 model compound I. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1sc00062d'> </P>
Sub-80 fs mode-locked Tm,Ho-codoped disordered garnet crystal oscillator operating at 2081 nm
Pan, Zhongben,Wang, Yicheng,Zhao, Yongguang,Kowalczyk, Maciej,Sotor, Jarosław,Yuan, Hualei,Zhang, Yan,Dai, Xiaojun,Cai, Huaqiang,Bae, Ji Eun,Choi, Sun Young,Rotermund, Fabian,Loiko, Pavel,Serres, Jose The Optical Society 2018 Optics letters Vol.43 No.20
67-fs pulse generation from a mode-locked Tm,Ho:CLNGG laser at 2083 nm
Zhao, Yongguang,Wang, Yicheng,Chen, Weidong,Pan, Zhongben,Wang, Li,Dai, Xiaojun,Yuan, Hualei,Zhang, Yan,Cai, Huaqiang,Bae, Ji Eun,Choi, Sun Young,Rotermund, Fabian,Loiko, Pavel,Serres, Josep Maria,Mat The Optical Society 2019 Optics express Vol.27 No.3