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Acid resistance mechanisms in enterohemorrhagic Escherichia coli O157:H7
Seon Mi Wi,Jang Won Yoon 한국예방수의학회 2018 예방수의학회지 Vol.42 No.3
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne bacterial pathogen that causes various diseases in both humans and animals such as hemorrhagic colitis and hemolytic uremic syndrome. Because cattle are the main reservoir of this microorganism, undercooked meat and meat byproducts contaminated with EHEC O157:H7 are most commonly associated with epidemic disease outbreaks. As an enteric pathogen, EHEC O157:H7 enters the body via a fecal-oral route and must survive passage through the gastric stomach at pH 1.5 to 3.5 to establish an infection within the gastrointestinal tracts. Therefore, the ability to resist such acidic environments is important to the pathogenesis of EHEC O157:H7 during a host infection. In this review, we will discuss on the acid resistance (AR) mechanisms induced by EHEC O157:H7 when E. coli encounters acidic environments.
미용덤벨 운동이 노인의 근감소증 예방을 위한 신체조성, 체력 및 혈중지질에 미치는 영향
소위영(Wi-Young So),송미순(Mi-Soon Song),조비룡(Be-Long Cho),박연환(Yeon-Hwan Park),김연수(Yeon-Soo Kim),임재영(Jae-Young Lim),김선호(Seon-Ho Kim),송욱(Wook Song) 한국노년학회 2009 한국노년학 Vol.29 No.3
많은 선행연구는 대규모 역학조사를 통하여 노화와 함께 근육의 감소가 나타나는 현상을 규명하였고, 이를 근감소증(sarcopenia)으로 명명하였다. 근감소증이 사망률과 유병률에 직접적인 관련성을 나타내지 않는 것 같으나 근육의 감소는 근력의 저하, 체력의 약화, 활동성의 감소로 이어져 결국에는 독립적인 생활이 불가능해지며 신체장애를 가져오게 된다. 본 연구는 근감소증 예방을 위한 미용덤벨 운동의 효과를 살펴보는데 있다. 본 연구의 피검자는 S시 J구에 소재한 J노인복지관 운동프로그램에 참가하는 60-70대의 노인으로 통제군 19명, 운동군 8명으로 분류하였다. 미용덤벨 운동은 12주 동안 주2회의 빈도로 실시하여, 운동 전ㆍ후로 신체조성, 체력, 혈중지질 변인을 측정하였다. 12주간의 미용덤벨 전ㆍ후 체지방률(F=0.388, p=0.539)은 유의한 차이가 나타나 지 않았으나, 체중(F=4.312, p=0.048), 체질량지수(F=4.532, p=0.043), 근육량(F=4.743, p=0.039)은 유의한 차이가 나타났다. 체력의 덤벨들기(F=1.103, p=0.304), 등 뒤에서 손잡기(F=0.214, p=0.648)는 유의한 차이가 나타나지 않았으나, 2분 제자리 걷기(F=33.638, p<0.001), 의자에서 일어섰다 앉기(F=14.575, p=0.001), 의자앉아 앞으로 굽히기(F=7.198, p=0.013), 244cm 왕복 걷기(F=14.890, p=0.001)는 유의한 차이가 나타났다. 혈중지질 변인의 총콜레스테롤(F=0.030, p=0.864), 중성지방(F=0.142, p=0.710), 고밀도지단백(F=2.066, p=0.163), 혈당(F=0.125, p=0.727), 당화혈색소(F=0.945, p=0.340)는 유의한 차이가 나타나지 않았다. 노인에게 있어서 미용덤벨 운동은 신체조성 및 체력에 긍정적인 영향을 미치나 혈중지질 변인에는 그렇지 못한 것을 확인할 수 있었다. Previous epidemiological studies reported that significant muscle loss is observed with advancing aging, called sarcopenia. This study is to investigate the effects of treatment dumbbell exercise on prevention of sarcopenia. The subjects were elderly between 60~70 years old who participated in J-Welfare senior center exercise program at J-gu in S-city and divided into control group(N=19) and exercise group(N=8). Treatment dumbbell exercise was performed 2 times per week for 12 weeks and body composition, fitness, and blood lipid profiles were measured before and after this program. There was no significance in body fat before and after 12 weeks of treatment dumbbell exercise, but there was significance in weight(F=4.312, p=0.048), BMI(F=4.532, p=0.043), and FFM(F=4.743, p=0.039). There was no significance in fitness such as arm curl(F=1.103, p=0.304), and back scratch(F=0.214, p=0.648), but there was significance in 2-minute step(F=33.638, p<0.001), chair stand(F=14.575, p=0.001), chair sit and reach(F=7.198, p=0.013), and 8-ft up and go(F=14.890, p=0.001). The variables of blood lipid profiles such as TC(F=0.030, p=0.864), TG(F=0.142, p=0.710), HDL(F=2.066, p=0.163), glucose (F=0.125, p=0.727), and HbA1c(F=0.945, p=0.340) has no significance. It was found that treatment dumbbell exercise has positive effects on body composition and fitness but has no positive effects on blood lipid profiles of the elderly.