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Application of Next Generation Sequencing in Laboratory Medicine
Zhong Yiming,Xu Feng,Wu Jinhua,Schubert Jeffrey,Li Marilyn M. 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.1
The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine. This review describes current sequencing technologies, including short- and long-read sequencing technologies, and highlights the clinical application of NGS in inherited diseases, oncology, and infectious diseases. We review NGS approaches and clinical diagnosis for constitutional disorders; summarize the application of U.S. Food and Drug Administration-approved NGS panels, cancer biomarkers, minimal residual disease, and liquid biopsy in clinical oncology; and consider epidemiological surveillance, identification of pathogens, and the importance of host microbiome in infectious diseases. Finally, we discuss the challenges and future perspectives of clinical NGS tests.
Zhang, Xiaobo,Pint, Cary L.,Lee, Min Hyung,Schubert, Bryan Edward,Jamshidi, Arash,Takei, Kuniharu,Ko, Hyunhyub,Gillies, Andrew,Bardhan, Rizia,Urban, Jeffrey J.,Wu, Ming,Fearing, Ronald,Javey, Ali American Chemical Society 2011 NANO LETTERS Vol.11 No.8
<P>A simple approach is described to fabricate reversible, thermally- and optically responsive actuators utilizing composites of poly(<I>N</I>-isopropylacrylamide) (pNIPAM) loaded with single-walled carbon nanotubes. With nanotube loading at concentrations of 0.75 mg/mL, we demonstrate up to 5 times enhancement to the thermal response time of the nanotube-pNIPAM hydrogel actuators caused by the enhanced mass transport of water molecules. Additionally, we demonstrate the ability to obtain ultrafast near-infrared optical response in nanotube-pNIPAM hydrogels under laser excitation enabled by the strong absorption properties of nanotubes. The work opens the framework to design complex and programmable self-folding materials, such as cubes and flowers, with advanced built-in features, including tunable response time as determined by the nanotube loading.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-8/nl201503e/production/images/medium/nl-2011-01503e_0002.gif'></P>