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- 저자 : Sato Mikako (검색결과 2 건)
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Hayashi Nanako,Nagatsuka Haruna,Sato Mikako,Kazushige Goto 한국운동영양학회 2023 Physical Activity and Nutrition (Phys Act Nutr) Vol.27 No.2
[Purpose] Exercise-induced hemolysis, which is caused by metabolic and/or mechanical stress during exercise, is considered a potential factor for upregulating hepcidin. Intramuscular carnosine has multiple effects including antioxidant activity. Therefore, this study aimed to determine whether long-term carnosine/ anserine supplementation modulates exercise-induced hemolysis and subsequent hepcidin elevation. [Methods] Seventeen healthy male participants were allocated to two different groups: participants consuming 1,500 mg/day of carnosine/anserine supplements (n = 9, C+A group) and participants consuming placebo powder supplements (n = 8, PLA group). The participants consumed carnosine/anserine or placebo supplements daily for 30.7 ± 0.4 days. They performed an 80-running session at 70% V4 O pre-and 2peak post-supplementation. Iron regulation and inflammation in response to exercise were evaluated. [Results] Serum iron concentrations significantly increased after exercise (p < 0.01) and serum haptoglobin concentrations decreased after exercise in both groups (p < 0.01). No significant differences in these variables were observed between pre-and post-supplementation. Serum hepcidin concentration significantly increased 180 min after exercise in both groups (p < 0.01). The integrated area under the curve of hepcidin significantly decreased after supplementation (p = 0.011) but did not vary between the C+A and PLA groups. [Conclusion] Long-term carnosine/anserine supplementation does not affect iron metabolism after a single endurance exercise session.
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Effect of Polyphenols in Sea Buckthorn Berry on Chemical Mediator Release from Mast Cells
Shiman Qiu,Anuu Zorig,Naoko Sato,Ai Yanagihara,Tsutomu Kanazawa,Mikako Takasugi,Hirofumi Arai 한국식품영양과학회 2023 Preventive Nutrition and Food Science Vol.28 No.3
Sea buckthorn (Hippophae rhamnoides L.) is a deciduous shrub of the Elaeagnaceae family and is widely distributed in northern Eurasia. Sea buckthorn berry (SBB) has attracted attention for its use in many health foods, although its physiological function remains unknown. In this study, we investigated the inhibitory effect of SBB extract and its fractions on Type-I allergy using mast cell lines. Among these fractions, SBB fraction with the highest amount of antioxidant polyphenols significantly inhibited the release of chemical mediators such as histamine and leukotriene B4 (LTB4) from the stimulated mast cells. This fraction also inhibited the influx of calcium ions (Ca<SUP>2+</SUP>) and the phosphorylation of tyrosine residues in proteins, including spleen tyrosine kinase, which is associated with signal transduction during the release of chemical mediators. The active SBB fraction contained isorhamnetin as its major flavonol aglycon. Isorhamnetin inhibited histamine and LTB₄ release from the stimulated cells and suppressed intracellular Ca<SUP>2+</SUP> influx. These results indicate that isorhamnetin is the primary substance responsible for the antiallergic activity in SBB. In conclusion, SBB may alleviate Type-I allergy by inhibiting the release of chemical mediators from mast cells, and polyphenols may contribute to this effect.
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