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RISS 인기검색어
- 검색키워드
- 저자 : Samir A. Ross (검색결과 4 건)
- 무료
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Amgad I. M. Khedr,Sabrin R. M. Ibrahim,Gamal A. Mohamed,Hany E. A. Ahmed,Amany S. Ahmad,Mahmoud A. Ramadan,Atef E. Abd El-Baky,Koji Yamada,Samir A. Ross 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7
Phytochemical investigation of Ficus pandurataHance (Moraceae) fruits has led to the isolation of two newtriterpenoids, ficupanduratin A [1b-hydroxy-3b-acetoxy-11a-methoxy-urs-12-ene] (11) and ficupanduratin B [21ahydroxy-3b-acetoxy-11a-methoxy-urs-12-ene] (17), alongwith 20 known compounds: a-amyrin acetate (1), a-amyrin(2), 3b-acetoxy-20-taraxasten-22-one (3), 3b-acetoxy-11amethoxy-olean-12-ene (4), 3b-acetoxy-11a-methoxy-12-ursene (5), 11-oxo-a-amyrin acetate (6), 11-oxo-b-amyrinacetate (7), palmitic acid (8), stigmast-4,22-diene-3,6-dione(9), stigmast-4-ene-3,6-dione (10), stigmasterol (12), b-sitosterol(13), stigmast-22-ene-3,6-dione (14), stigmastane-3,6-dione (15), 3b,21b-dihydroxy-11a-methoxy-olean-12-ene (16), 3b-hydroxy-11a-methoxyurs-12-ene (18), 6-hydroxystigmast-4,22-diene-3-one (19), 6-hydroxystigmast-4-ene-3-one (20), 11a,21a-dihydroxy-3b-acetoxy-urs-12-ene(21), and b-sitosterol-3-O-b-D-glucopyranoside (22). Compound21 is reported for the first time from a natural source. The structures of the 20 compounds were elucidated on thebasis of IR, 1D (1H and 13C), 2D (1H–1H COSY, HSQC,HMBC and NOESY) NMR and MS spectroscopic data, inaddition to comparison with literature data. The isolatedcompounds were evaluated for their anti-microbial, antimalarial,anti-leishmanial, and cytotoxic activities. In addition,their radioligand displacement affinity on opioid andcannabinoid receptors was assessed. Compounds 4, 11, and15 exhibited good affinity towards the CB2 receptor, withdisplacement values of 69.7, 62.5 and 86.5 %, respectively. Furthermore, the binding mode of the active compounds inthe active site of the CB2 cannabinoid receptors was investigatedthrough molecular modelling.
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C-Flavonoidal Glycosides from Erythrina caffra Flowers
Sawsan El Masry,Hala M. Hammoda,Mohamed M. Radwan,Samir A. Ross,Hala H. Zaatout 한국생약학회 2010 Natural Product Sciences Vol.16 No.4
A phytochemical investigation of the ethanolic extract of Erythrina caffra flowers from an Egyptian origin yielded three C-flavonoidal glycosides; 5,7,4`-trihydroxyflavone-8-C-β-D-glucopyranoside (vitexin) (1), 5,7,4`-trihydroxyflavone-6-C-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (isovitexin-2``-β-D-glucopyranoside) (2), 5, 7, 4`-trihydroxyflavone-6, 8-di-C-β-D-glucopyranoside (vicenin-2) (3) and one O-flavonoidal glycoside; kaempferol-3-O-β-D-glucopyranosyl) (1→2)-β-D-glucopyranoside (4). The structures of the isolated compounds (1 - 4) were elucidated using different spectral techniques (UV, 1D and 2D NMR and HRESIMS). This is the first report for the isolation of flavonoidal glycosides from Erythrina caffra. The antibacterial, antifungal, antimalarial, and antileishmanial activities of the isolates were evaluated. In addition, the cytotoxic activity of the ethanolic extract and the main fractions were tested using brine shrimp bioassay.
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New anti-inflammatory flavonoids from Cadaba glandulosa Forssk
Gamal A. Mohamed,Sabrin R. M. Ibrahim,Nawal M. Al-Musayeib,Samir A. Ross 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
Three new flavonoids; kaempferol-40-phenoxy-3,30,50-trimethylether (3), rhamnocitrin-40-(4-hydroxy-3-methoxy)phenoxy-3-methyl ether (4), and rhamnocitrin-3-O-neohesperoside-40-O-rhamnoside (6), along with threeknown compounds; 4-methoxy-benzyldehyde (1),kaempferol-3-methylether (2), and stachydrine (5) wereisolated from the aerial parts of Cadaba glandulosa Forssk. Their chemical structures were established by physical,chemical, and spectral methods, as well as comparison with literature data. The antioxidant and anti-inflammatoryactivities of the isolated compounds were determined. Compounds 2–4, and 6 exhibited potent anti-inflammatoryactivity comparable with indomethacin and moderateantioxidant activity.
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New anti-inflammatory flavonoids from Cadaba glandulosa Forssk
Mohamed, Gamal A.,Ibrahim, Sabrin R.M.,Al-Musayeib, Nawal M.,Ross, Samir A. 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
Three new flavonoids; kaempferol-4'-phenoxy-3,3',5'-trimethylether (3), rhamnocitrin-4'-(4-hydroxy-3-methoxy)phenoxy-3-methyl ether (4), and rhamnocitrin-3-O-neohesperoside-4'-O-rhamnoside (6), along with three known compounds; 4-methoxy-benzyldehyde (1), kaempferol-3-methylether (2), and stachydrine (5) were isolated from the aerial parts of Cadaba glandulosa Forssk. Their chemical structures were established by physical, chemical, and spectral methods, as well as comparison with literature data. The antioxidant and anti-inflammatory activities of the isolated compounds were determined. Compounds 2-4, and 6 exhibited potent anti-inflammatory activity comparable with indomethacin and moderate antioxidant activity.
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