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( Kazutami Sakamoto ),( Yuji Yamashita ),( Hiroyasu Ohtaka ),( Yosuke Hashimoto ),( Masaki Takemura ),( Yoshikazu Uchida ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Trans-Urocanic acid (t-UCA) is recognized as an end metabolite of filaggrin via histidine which is a part of NMF amino acids in the stratum corneum (SC). As an intrinsic chromophore in SC under UV exposure, t-UCA converts to cis isomer (c-UCA) which initiates UV-induced immunosuppression. There are controversial discussions about c-UCA whether its immunosuppressive function is for the protection of body or rather to trigger carcinogenic reactions. Even though, existence of t-UCA in SC and conversion to c-UCA by UV radiation is real events evolved in Nature for the mammalian skin especially in human. The objective of this study is to investigate the transient isomerization of t-UCA in SC to c-UCA during the course of seasonal solar UV Index change in order to better understand the role of UCA for the skin physiology. Ten volunteers with age 21 to 34 are recruited and UCA isomer ratio was measured twice a week for six weeks (Sep 14th through Oct 19 in 2012). SC samples were tape stripped from the inner upper arm and UCA isomers are analyzed by HPLC. Average cis/trans ratio decreased gradually from c.a. 2.0 to 0.2. Solar UV Index reported for the area of experiment also decreased by the duration of days during the 6 weeks test period and there are good correlation found between isomer ratio and Solar UV Index. As a result, dynamic photo-isomerization of UCA in response to the solar UV radiation was confirmed. This finding would lead us further investigation of the functional roles of UCA in the skin especially for the Filaggrin mutation and Atopic Dermatitis, which is one of the hot topics in skin science.
Yusuke Okuda,Tomonori Yamada,Yoshikazu Hirata,Takaya Shimura,Ryuzo Yamaguchi,Eiji Sakamoto,Satoshi Sobue,Takahiro Nakazawa,Hiromi Kataoka,Takashi Joh 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Since oncological outcomes of transanal colorectal tube (TCT) placement, an endoscopic treatment for colorectal cancer (CRC) with acute colorectal obstruction (ACO), remain unknown, this study analyzed long-term outcomes of TCT placement for stage II/III CRC with ACO. Materials and Methods Data were retrospectively reviewed from consecutive patients with distal stage II/III CRC who underwent surgery between January 2007 and December 2011 at two Japanese hospitals. One hospital conducted emergency surgery and the other performed TCT placement as the standard treatment for all CRCs with ACO. Propensity score (PS) matching was used to adjust baseline characteristics between two groups. Results Among 754 patients with distal stage II/III CRC, 680 did not have ACO (non-ACO group) and 74 had ACO (ACO group). The PS matching between both hospitals identified 234 pairs in the non-ACO group and 23 pairs in the ACO group. In the non-ACO group, the surgical quality was equivalent between the two institutions, with no significant differences in overall survival (OS) and disease-free survival (DFS). In the ACO group, the rate of primary resection/anastomosis was higher in the TCT group than in the surgery group (87.0% vs. 26.1%, p < 0.001). No significant differences were noted between the surgery and the TCT groups in OS (5-year OS, 61.9% vs. 51.5%; p=0.490) and DFS (5-year DFS, 45.9% vs. 38.3%; p=0.658). Conclusion TCT placement can achieve similar long-term outcomes to emergency surgery, with a high rate of primary resection/anastomosis for distal stage II/III colon cancer with ACO.