Possible Prognostic Role of HER2/Neu in Ductal Carcinoma In Situ and Atypical Ductal Proliferative Lesions of the Breast

Daoud, Sahar Aly,Ismail, Wesam Maghawri,Abdelhamid, Mohamed Salah,Nabil, Tamer Mohamed,Daoud, Sahar Aly Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

HER2/neu is a well-established prognostic and predictive factor for invasive breast cancer. However, the role of HER2/neu in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that it is mainly linked to in situ local recurrence. Although molecular data suggest that atypical ductal hyperplasia (ADH) and duct carcinoma in situ (DCIS) are related lesions, albeit with vastly different clinical implications, the role of HER2/neu expression in atypical ductal hyperplasia is not well defined either. The aim of this study was to evaluate over expression of HER2/neu in DCIS and cases of ADH in comparison with invasive breast carcinoma. Archival primary breast carcinoma paraffin blocks (n=15), DCIS only (n=10) and ductal epithelial hyperplasia and other breast benign lesions (n=25) were analyzed for HER2/neu immunoexpression. Follow up was available for 40% of the patients. HER2/neu was positive in 80%of both DCIS and invasive carcinoma, and 67% of atypical ductal hyperplasia (ADH) cases. Thus at least a subset of patients with preinvasive breast lesions were positive, which strongly suggests a role for Her2/neu in identifying high-risk patients for malignant transformation. Although these are preliminary data, which need further studies of gene amplification within these patients as well as a larger patient cohort with longer periods of follow up, they support the implementation of routine Her2/neu testing in patients diagnosed as pure DCIS and in florid ADH.

ENTANGLED DEVOTIONAL COMMITMENTS: READING THE BURDAH IN EGYPT, SOUTH AFRICA, AND INDONESIA

Sahar Ishtiaque Ullah 한국외국어대학교 아프리카연구소 2020 Asian Journal of African Studies Vol.- No.48

Certain poems and stories are buried as cultural artifacts; others never die; and still others are revived from death. The thirteenth century Qaṣīdat al-Burdah, composed by Muḥammad ibn Sa’īd al-Būṣīrī (d. 693/1294), is a love poem dedicated to the Prophet Muhammad. The exemplary Arabic-Islamic work has seen renewed popularity among Muslim communities in the last two decades, from its origins in Egypt to Indonesia to locations where Muslims are a religious minority, and hundreds of youtube recordings with millions of views that demonstrate this. The poem has been dramatically staged, academically researched, and devotionally recited. In this article, I analyze the entangled devotional commitments to the Qaṣīdat al-Burdah as demonstrated by its modern iterations in Egypt, Indonesia, and South Africa and consider what we can learn about the role of audience and community in creating meaning.

Promoting the American Senior Tourism to Egypt

Sahar Ibrahim Elkadi,Soha Mohamed Abd el Wahab 세계문화관광학회 2008 Conference Proceedings Vol.9 No.0

Mindful of the global rapid growth in senior tourism, this research aims at studying and evaluating the industry operators' role towards increasing Egypt's market share of the American senior traffic. Within this context, three questionnaire forms were directed to the concerned public and private organizations, and to a random sample of the American seniors in Egypt to stand over the strategies of matching the Egyptian tourism product to the current seniors' wants and expectations. It was concluded that the Egyptian actors must be more senior oriented through advocating innovative approaches to satisfy the American seniors better than the competition.

Concentrically Loaded Circular RC Columns Partially Confined with FRP

Sahar Y. Ghanem,Issam E. Harik 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.5

Wrapping reinforced concrete (RC) columns with fiber reinforced polymer (FRP) composites is effective in increasing their capacity. The current state of the art concentrates primarily on fully wrapped columns and few studies dealt with partially wrapped ones. The objective herein is to evaluate the effectiveness of partial wraps (or strips) and to develop a confined concrete compressive stress.strain (fc - εc) model that accounts for partial wrapping. Three-dimensional finite element (FE) models are generated to evaluate the influence of different parameters on the behavior of concentrically loaded RC circular columns that are partially and fully wrapped with FRP. The results indicated an increase in ductility as the number of FRP strips is increased, and revealed that longitudinal steel had little influence on the confined fc . εc relationship. The proposed fc . εc model, derived from the parametric study, accounts for the effect of partial and full confinement, the unconfined concrete strength f ′c , and yielding of transverse steel. Comparison of the results generated using the proposed model with FE and experimental results are in good agreement.

Process Quality Levels of ISO/IEC 15504, CMMI and K-model

Sahar Sohrabi 보안공학연구지원센터 2009 International Journal of Software Engineering and Vol.3 No.1

In the current marketplace, there are maturity models, standards, and guidelines that can help an organization improve the way it does business. Software process assessment models, ISO/IEC 15504 and CMMI provide good strategy to assess organization’s software development capability. However these models are too heavy to apply small and medium enterprise organization. A ISO/IEC 15504(Software Process Improvement and Capability determination) and CMMI(Capability Maturity Model Integration) can be considered as representative software process assessment models since assessors assign ratings to indicators and metrics to measure the capability of software processes. In this paper we show the K-model that can easily apply small and medium sized business to process improvement and certification in Korea. This study also compares the practices of K-model with practices of CMMI and ISO/IEC 15504. We expect the small and light model, K-model will make software process improvement of Korea enterprises.

Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population

Sahar Moghbelinejad,Reza Najafipour,Abdolmabood Momeni 한국유전학회 2018 Genes & Genomics Vol.40 No.1

Since genes involved in microRNA biogenesis pathways have a main role in impaired spermatogenesis, in this research, we evaluated different genotypes frequency of seven single-nucleotide polymorphisms in DICER1 and DROSHA genes. Different genotypes frequency of DICER1 (rs12323635, rs1057035, rs13078 and rs3742330) and DROSHA (rs10719, rs642321 and rs2291102) were determined by sequencing method in 385 infertile men and 120 fertile controls. It was found that CC genotype (P = 0.000) and C allele (P = 0.0) of rs1057035 T > C polymorphism were associated with idiopathic male infertility (azoospermia). Gene expression study in blood and testis samples was done by real time PCR technique. Our results showed significant under expression of DICER1 gene in blood and testis tissues of azoospermic samples (P < 0.05), but we did not observed significant difference in expression ratio between infertile men with and without C allele of rs1057035 SNP (P > 0.05). The results of this study showed that among the studied variants, only one of them in DICER1 might be associated with azoospermia, but additional studies needs in different populations and ethnics.

Evaluation of liquefaction potential of soil using the shear wave velocity in Tehran, Iran

Sahar Rahmanian,Fereydoun Rezaie 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.1

Shear-wave velocity (VS) offers a means to determine the seismic resistance of soil to liquefaction by a fundamental soil property. Iwasaki’s (1982) method is used to measure the liquefaction potential index for both of them. It follows the general format of the Seed-Idriss (1685) simplified procedure based on standard penetration test blow count and shear wave velocity (VS) on the basis of Andrus et al. (2004) using case history data from 43 boreholes in soils ranging from fine sand, silty sand, gravely sand to profiles including silty clay layers and the average soil shear wave velocity (VS 30) in the south Tehran. Liquefaction resistance curves were established by applying a modified relationship between the shear-wave velocity and cyclic stress ratio for the constant average cyclic shear strain. The study area is the south-east of Tehran and the route of Tehran Metro Line 7. It is observed that there is not a perfect agreement between the results of the two methods based on five empirical relationships assuming cemented and non-cemented condition for soils. Moreover, the liquefaction potential index (PL) value in the Standard Penetration Test (SPT) method is more than that of the VS method. Liquefaction potential index (PL) values based on shear wave velocity (VS) using five empirical relationships in two un-cemented and cemented soil show that the used relations are overestimated and most of them have shown non-liquefaction condition for soils in the studied area.

Solvent and Solvent to Sample Ratio as Main Parameters in the Microwave-assisted Extraction of Polyphenolic Compounds from Apple Pomace

Sahar Rezaei,Karamatollah Rezaei,Maryam Haghighi,Mohsen Labbafi 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5

Microwave-assisted extraction (MAE) in the presence of ethanol and water as solvents was applied as a modern technique to extract polyphenolic compounds from apple pomace and the results were compared to those of Soxhlet extraction and maceration. Various experimental conditions such as microwave power, extraction time, type of solvent, and solvent to sample ratio were considered for the study. Increasing microwave power (from 90 to 360 W)resulted in lower extraction yields. Ethanol-water (at the ratio of 65 to 35) was the best solvent for MAE. However,for the sake of higher water contribution in the extraction,a ratio of 35:65 (ethanol:water) can be selected for a recovery of -90% at a shorter extraction time. The best solvent to sample ratio was found at 20 to 1 level. When used for the extraction of polyphenolic compounds from apple pomace, MAE was faster than maceration and Soxhlet methods.

Durability assessment of self-compacting concrete with fly ash

Sahar Deilami,Farhad Aslani,Mohamed Elchalakani 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.5

Self-Compacting Concrete (SCC) is a new technology capable to flow without segregation or any addition of energy which leads to efficient construction and cost savings. In this study, the effect of replacing the Ordinary Portland Cement (OPC) with Fly Ash (FA) on the strength, durability of the concrete was investigated experimentally, and carbon footprint and cost were also assessed. Four different replacement FA ratios (0%, 20%, 40% and 60%) were used to create four SCC mixes. Standard test methods were used to determine the workability, strength, and durability of the SCC mixes including resist chloride ion penetration, water permeability, water absorption, and initial surface absorption. The axial cube compressive strength tests were performed on the SCC mixes at 1, 7, 14, 28 and 35 days. Replacing the OPC with FA had a significant positive impact on chloride iron penetration resistance and water absorption but had a considerable negative impact on the compressive strength. The SCC mix with 60% FA had 36.7% and 15.8% enhancement in the resistance to chloride ion penetration and water absorption, respectively. Evaluation of the carbon footprint and the cost of each SCC mixes showed the CO2 emissions mixes 1, 2, 3 and 4 were significantly reduced by increasing the FA content from 0% to 60%. Compared with the control mix, the cost of all mixes increased when the FA content increased, but no significant differences were seen between the estimated costs of all four mixes.

Safety and Efcacy of Cerebrolysin in Infants with Communication Defects due to Severe Perinatal Brain Insult: A Randomized Controlled Clinical Trial

Sahar M.A. Hassanein,Shaymaa M. Deifalla,Moustafa El-Houssinie,Somaia A. Mokbel 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.1

Background and Purpose Te neuroregenerative drug Cerebrolysin has demonstrated efcacy in improving cognition in adults with stroke and Alzheimer’s disease. Te aim of this study was to determine the efcacy and safety of Cerebrolysin in the treatment of communication defects in infants with severe perinatal brain insult. Methods A randomized placebo-controlled clinical trial was conducted in which 158 infants (age 6–21 months) with communication defects due to severe perinatal brain insult were enrolled; 120 infants completed the study. The Cerebrolysin group (n=60) received twice-weekly Cerebrolysin injections of 0.1 mL/kg body weight for 5 weeks (total of ten injections). Te placebo group (n=60) received the same amount and number of normal saline injections. Results Te baseline Communication and Symbolic-Behavior-Scale-Developmental Profle scores were comparable between the two groups. Afer 3 months, the placebo group exhibited improvements in the social (p<0.01) and speech composite (p=0.02) scores, with 10% and 1.5% increases from baseline, respectively. Te scores of the Cerebrolysin group changed from concern to no concern, with increases of 65.44%, 45.54%, 358.06%, and 96.00% from baseline in the social (p<0.001), speech (p<0.001), symbolic (p<0.001), and total (p<0.001) scores. Conclusions Cerebrolysin dramatically improved infants’ communication especially symbolic behavior which positively afected social interaction. Tese fndings suggest that cerebrolysin may be an efective and feasible way equivalent to stem cell therapy.