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Anuj G. Agrawal,Ashok Kumar,Paraag S. Gide 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
Coenzyme Q10 (CQ10) is known as an endogenouscellular antioxidant, naturally found in every cell ofthe human body and plays an important role in maintaininghuman health. It is widely used as a nutritional supplementand pharmaceutical drug for various disorders like diabetesmellitus, carcinomas, neurodegenerative disorders etc. However, CQ10 is practically insoluble even in the presenceof 5 % sodium lauryl sulfate in water and poorlyabsorbed from the gastrointestinal tract. The presentresearch is aimed to formulate and evaluate self nanoemulsifyingdrug delivery system (SNEDDS) of CQ10primarily to improve its aqueous solubility, dissolutionvelocity as well as hepatoprotective activity and thusenhancing its nutraceutical and pharmaceutical values. Robustness to dilution, thermodynamic stability study,droplet size analysis and drug release were adopted tooptimize liquid SNEDDS. Droplet size of the SNEDDSwas found to be size less than 200 nm and appeared roundin shape without aggregation under transmission electronmicroscopy examination. Liquid SNEDDS were adsorbedon porous carrier to get solid SNEDDS (S-SNEDDS). S-SNEDDS gave rapid ([90 %) drug release within30 min while pure drug was not practically dissolvedwithin 1 h. In vivo hepatoprotective activity showed thatS-SNEDDS achieved the most liver protection as comparedto the pure drug. Further S-SNEDDS was successfullyconverted to self nanoemulsifying mouth dissolving tablet. The enhanced solubility, dissolution velocity as well ashepatoprotective activity of CQ10, unravels the potential ofS-SNEDDS as suitable carrier for enhancing nutraceuticaland pharmaceutical values of CQ10.
Kumar, V.,Sankaranarayanan, M.,Durgapal, M.,Zhou, S.,Ko, Y.,Ashok, S.,Sarkar, R.,Park, S. Elsevier Applied Science 2013 Bioresource technology Vol.135 No.-
In the present study, the lactate dehydrogenase-deficient (ldhA<SUP>-</SUP>) recombinant Klebsiella pneumoniae overexpressing an ALDH (KGSADH) was developed and the co-production of 3-HP and PDO from glycerol by this recombinant under resting cell conditions was examined. The new recombinant did not produce any appreciable lactate, which seriously inhibits the production of 3-HP and PDO. The final titers of 3-HP and PDO by the ldhA<SUP>-</SUP> recombinant strain at 60h were 252.2mM and 308.7mM, respectively, which were improved by approximately 30% and 50%, respectively, compared to those by the counterpart recombinant strain, which was the wild type for ldhA. In addition, after deleting ldhA, the cumulative yield on glycerol and specific production rate of these two metabolites (3-HP and PDO) were enhanced by 41.4% and 52%, respectively.
Kumar, S. Ashok,Sankar, J. Navin,Dileepan, D.,Shanmuganantham, T. The Korean Institute of Electrical and Electronic 2015 Transactions on Electrical and Electronic Material Vol.16 No.5
A novel implantable CPW fed Apollian shaped antenna embedded into human tissue is proposed for ISM band biomedical applications. The proposed antenna is made compatible for implantation by embedding it in an alumina ceramic substrate(ε<sub>r</sub>=9.8 and thickness= 0.65 mm). The proposed antenna covers the ISM band of 2.45 GHz. The radiation parameters such as return loss, xy-plane, xz-plane, and yz-plane etc., are measured and analyzed using the agilent vector network analyzer. The proposed antenna has substantial advantages, including low profile, miniaturization ability, lower return loss, better impedance matching, and high gain over conventional implanted antennas.
Design of Implantable CPW Fed Monopole Antenna for ISM Band Applications
Kumar, S. Ashok,Shanmuganantham, T. The Korean Institute of Electrical and Electronic 2014 Transactions on Electrical and Electronic Material Vol.15 No.2
An implantable CPW fed monopole antenna embedded into human tissue is proposed for ISM band biomedical applications. The proposed antenna is made compatible for implantation by embedding it in an alumina ceramic substrate (${\Box}_r=9.8$ and thickness=0.65 mm). The proposed antenna covers the ISM band of 2.45 GHz. The radiation parameters, such as return loss, E-Plane, H-Plane, are measured and analyzed, using the method of moments. The proposed antenna has substantial merits over other implanted antennas, like low profile, miniaturization, lower return loss, and better impedance matching and high gain.
S. Ashok Kumar,J. Navin Sankar,D. Dileepan,T. Shanmuganantham 한국전기전자재료학회 2015 Transactions on Electrical and Electronic Material Vol.16 No.5
A novel implantable CPW fed Apollian shaped antenna embedded into human tissue is proposed for ISM band biomedical applications. The proposed antenna is made compatible for implantation by embedding it in an alumina ceramic substrate(εr=9.8 and thickness= 0.65 mm). The proposed antenna covers the ISM band of 2.45 GHz. The radiation parameters such as return loss, xy-plane, xz-plane, and yz-plane etc., are measured and analyzed using the agilent vector network analyzer. The proposed antenna has substantial advantages, including low profile, miniaturization ability, lower return loss, better impedance matching, and high gain over conventional implanted antennas.
Design and Performance of Textile Antenna for Wearable Applications
S. Ashok Kumar,T. Shanmuganantham 한국전기전자재료학회 2018 Transactions on Electrical and Electronic Material Vol.19 No.5
In this paper, a novel co-planar waveguide fed textile antenna is to be designed for wearable applications. The designedantenna has the design parameters of the size is 90 mm × 70 mm × 1.57 mm 3 and the substrate is Jeans cloth whose dielectricconstant is 1.6. The proposed antenna resonates at 2.45 GHz with a return loss of − 19 dB. The proposed antenna has a gainof 2 dBi and VSWR is around 1.1 at the resonating frequency. This logo shaped antenna can be radically used in militaryjackets, because of its compatibility, fl exibility in structure design and shape, excellent performance at diff erent angles,human safety, miniaturization, power consumption etc.
Design of Implantable CPW Fed Monopole Antenna for ISM Band Applications
S. Ashok Kumar,T. Shanmuganantham 한국전기전자재료학회 2014 Transactions on Electrical and Electronic Material Vol.15 No.2
An implantable CPW fed monopole antenna embedded into human tissue is proposed for ISM band biomedicalapplications. The proposed antenna is made compatible for implantation by embedding it in an alumina ceramicsubstrate (□r=9.8 and thickness=0.65 mm). The proposed antenna covers the ISM band of 2.45 GHz. The radiationparameters, such as return loss, E-Plane, H-Plane, are measured and analyzed, using the method of moments. Theproposed antenna has substantial merits over other implanted antennas, like low profile, miniaturization, lowerreturn loss, and better impedance matching and high gain.
Fault test analysis in transmission lines throughout interfering synchrophasor signals
S. Ashok Kumar,D. Chandramohan 한국통신학회 2019 ICT Express Vol.5 No.4
The distribution of power supplies be obliged to offer reliable, superior-quality in power. To obtain good power quality the transmission line faults identification should bemore precise, consistence and complete rectification is required. The faults in the transmission and distribution lines influence the power quality. The major faults in transmission lines such as line to ground fault, line-to-line fault and three-phase faults. This paper proposes a unique organized interrelated structure for fault-location and classification technique for transmission lines through an experimental set-up similar to transmission and distribution for good power quality. The proposed method utilizes synchrophasor measurements during the disturbances from the transmission lines and compares with idealcondition signals for fault location and classification. From the results, the synchrophasor measurements identifies faults in the initial stage. The phasor measurement results are modelled through regression modelling for precise measurement. Various faults are modelled for the earlier detection in the transmission lines.
Design of Octagonal CPW-Fed Broadband Millimeter Wave Antenna for 5G Applications
S. Ashok Kumar,T. Shanmuganantham,D. Sindhaniselvi,A. L. Sharon Giftsy 한국전기전자재료학회 2023 Transactions on Electrical and Electronic Material Vol.24 No.2
A CPW-fed antenna is designed with octagonal shaped patch operating at a broadband millimeter-wave frequency from 24.8 to 48.8 GHz for wireless 5G applications. The antenna was design with dimensions of 20 × 20 × 1.6 mm 3 are made with low cost FR4 loss free substrate with dielectric constant (ε r ) of 4.3 using the CST Microwave Studio software. Simulated radiation pattern and return loss < -10 dB is achieved at a frequency of 28 GHz, 30.78 GHz, 38 GHz, 41.64 GHz and 44.16 GHz with the gain of 5.1 dB, 6.39 dB, 6.59 dB, 7.48 dB and 7.04 dB. The voltage standing wave ratio (VSWR) < 2 at (24.8–48.8) GHz which indicates that these frequencies operated by the antenna has minimum reflection.
Design of Bending Antennas for Purpose of Biomedical Applications Using Novel Approach
S. Ashok Kumar,T. Shanmuganantham 한국전기전자재료학회 2021 Transactions on Electrical and Electronic Material Vol.22 No.6
In this paper, design of a flexible antenna which is used in the field of biomedical applications. This technology consists of two methods mainly i.e. 1.Magnetron sputtering method, 2.Laser ablation method. Magnetron sputtering method is use to set slight copper coating upon polyimide substrate. Secondly Laser ablation method is mainly used to incise an antenna as of copper coat. The different parameters are simulated and measured practically. The outcomes of the verified results are good and have a satisfactory response. There are many advantages such as price, momentum, elasticity over lithography process frequently used for such applications.